NIZA티딘
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NIZA티딘 속성
- 녹는점
- 130-1320C
- 끓는 점
- 478.2±45.0 °C(Predicted)
- 밀도
- 1.249±0.06 g/cm3(Predicted)
- 저장 조건
- Keep in dark place,Inert atmosphere,Room temperature
- 용해도
- 물에 거의 용해되지 않으며 메탄올에 용해됩니다.
- 산도 계수 (pKa)
- 2.1, 6.8(at 25℃)
- 색상
- 황백색에서 연한 노란색
- 수용성
- 21.4g/L(온도 미표시)
- Merck
- 14,6660
- CAS 데이터베이스
- 76963-41-2(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xn | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 22 | ||
| 안전지침서 | 36 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | KM6565000 | ||
| HS 번호 | 29349990 | ||
| 유해 물질 데이터 | 76963-41-2(Hazardous Substances Data) | ||
| 독성 | LD50 in mice, rats (mg/kg): 265, >300 i.v.; 1685, 1680 orally (Pioch) | ||
| 기존화학 물질 | KE-11160 |
NIZA티딘 C화학적 특성, 용도, 생산
개요
Nizatidine is the fifth H2-antagonist introduced to the world market as an antiulcer agent. It is reported to be effective in the treatment of both duodenal and gastric ulcers or the prevention of their recurrences. Given once-daily, nizatidine’s bioavailability is not diminished by the concurrent administration of an antacid.화학적 성질
White Crystalline Powder용도
Nizatidine is used for treating stomach and duodenum ulcers and other conditions accompanied by elevated acidity of the gastrointestinal tract.Indications
Nizatidine is the newest H2-receptor antagonist. Similar to ranitidine, it has a relative potency twice that of cimetidine.About 90% of an oral dose is absorbed, with a peak plasma concentration occurring after 0.5 to 3 hours; inhibition of gastric secretion is present for up to 10 hours.The elimination half-life is 1 to 2 hours, and more than 90% of an oral dose is excreted in the urine.정의
ChEBI: A member of the class of 1,3-thiazoles having a dimethylaminomethyl substituent at position 2 and an alkylthiomethyl moiety at position 4.일반 설명
Nizatidine, N-[2-[[[2-(dimethylamino)methyl]-4-thiazolyl]methyl]thio]-ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (Axid), is an off-white to buff crystallinesolid that is soluble in water, alcohol, and chloroform. It isa thaizole derivative of raniditine and has pKas of 2.1 (side chain) and 6.8 (dimethylamino). Nizatidine’s mechanism ofaction is similar to other H2-antagonists, as is its receptor selectivity.It is more potent than cimetidine.Nizatidine has excellent oral bioavailability (＞90%).The effects of antacids or food on its bioavailability arenot clinically significant. The elimination half-life is 1 to2 hours. It is excreted primarily in the urine (90%) andmostly as unchanged drug (60%). Metabolites include nizatidinesulfoxide (6%), N-desmethylnizatidine (7%), andnizatidine N-oxide (dimethylaminomethyl function).Nizatidine has no demonstrable antiandrogenic action, effectson other hormones, or inhibitory effects on cytochromeisozymes involved in the metabolism of other drugs.
NIZA티딘 준비 용품 및 원자재
원자재
황화 수소
DimethylamineE
에틸렌디아민
나이트로메테인
비스 (클로로메틸) 케톤
2-Dimethylaminomethyl-4-Chloromethyl-4-hydrony thiazoline
THIAZOLIDINE
크리소이딘
Dimethyl aminothic acetamide
1-vinylpyrene
Dimethyl amino acetenitrile
초산에틸
2-DIMETHYL AMINO METHYL-4-CHLORO METHYL THIAZOLE HCL
메틸알콜
Anhydrous pyridine
사이클로헥사논
1,1-BIS(METHYLTHIO)-2-NITROETHYLENE
요오드 메탄
사이안화 칼륨
아세트알데히드암모니아
메틸아민
2-NITROMETHYLENETHIAZOLIDINE
준비 용품
NIZA티딘 공급 업체
글로벌( 369)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Hebei Jimi Trading Co., Ltd. | +86 319 5273535 |
bestoneforyou@sina.com | CHINA | 288 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 |
sales@amoychem.com | China | 6387 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 |
sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49390 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-29-87569265 +86-18612256290 |
1056@dideu.com | China | 3581 | 58 |
| WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD | +8615377521700 |
wangwendy93@gmail.com | China | 868 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 19892 | 58 |