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디에틸스틸베스트롤

디에틸스틸베스트롤
디에틸스틸베스트롤 구조식 이미지
카스 번호:
56-53-1
한글명:
디에틸스틸베스트롤
동의어(한글):
다이에틸스틸베스트롤;디에틸스틸베스트롤
상품명:
Diethylstilbestrol
동의어(영문):
DES;Stil;CSM1;CSM2;-PVT;ALPHA;Bufon;Cyren;Desma;Sibol
CBNumber:
CB9751457
분자식:
C18H20O2
포뮬러 무게:
268.35
MOL 파일:
56-53-1.mol

디에틸스틸베스트롤 속성

녹는점
170-172 °C(lit.)
끓는 점
351.51°C (rough estimate)
밀도
1.1096 (rough estimate)
굴절률
1.4800 (estimate)
저장 조건
0-6°C
용해도
methanol: 0.1 g/mL, clear, faintly yellow
산도 계수 (pKa)
pKa 9.02(H2O t=25 I=0.025) (Uncertain)
물리적 상태
Crystalline Powder
색상
White to almost white
수용성
PRACTICALLY INSOLUBLE
Merck
13,3155
BRN
2056095
안정성
Isomerizes rapidly in Benzene, Chloroform, and Ether. Keep Shielded from light.
CAS 데이터베이스
56-53-1(CAS DataBase Reference)
NIST
Diethylstilbesterol(56-53-1)
EPA
Phenol, 4,4'-[(1E)-1,2-diethyl- 1,2-ethenediyl]bis-(56-53-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T,N
위험 카페고리 넘버 45-61-36/37/38-51/53-40
안전지침서 53-36/37/39-45-60-61-36/37
유엔번호(UN No.) UN 3077 9/PG 3
WGK 독일 3
RTECS 번호 WJ5600000
F 고인화성물질 10
위험 등급 6.1(b)
포장분류 III
HS 번호 29072990
유해 물질 데이터 56-53-1(Hazardous Substances Data)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H315 피부에 자극을 일으킴 피부부식성 또는 자극성물질 구분 2 경고 P264, P280, P302+P352, P321,P332+P313, P362
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
H335 호흡 자극성을 일으킬 수 있음 특정 표적장기 독성 - 1회 노출;호흡기계 자극 구분 3 경고
H350 암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 1A, 1B 위험
H360 태아 또는 생식능력에 손상을 일으킬 수 있음 생식독성 물질 구분 1A, 1B 위험
H410 장기적 영향에 의해 수생생물에 매우 유독함 수생 환경유해성 물질 - 만성 구분 1 경고 P273, P391, P501
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P261 분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P273 환경으로 배출하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P501 ...에 내용물 / 용기를 폐기 하시오.

디에틸스틸베스트롤 MSDS


Diethylstilbestrol

디에틸스틸베스트롤 C화학적 특성, 용도, 생산

화학적 성질

White Solid

용도

A synthetic, nonsteroidal estrogen. Recomended solvents are DMSO, DMF and ethanol, even in these solvents do not store in solution for any prolonged period of time.

상표명

Stilbestrol (Tablicaps); Stilbetin (Bristol-Myers Squibb);Distilbene;Oestro-gynedron;Stilphostrol.

World Health Organization (WHO)

Diethylstilbestrol, a synthetic estrogen which is a stilbene derivative, was introduced into obstetric practice in the late 1940s and subsequently widely used for the treatment of threatened abortion. This use was later shown to be associated with an increased risk of vaginal cancer in the offspring which resulted in restrictive regulatory action in several countries. Diethylstilbestrol and other stilbenes remain available in many countries, however, for the treatment of certain hormone-dependent neoplasms including carcinoma of the prostate and postmenopausal breast cancer. (Reference: (WHODI) WHO Drug Information, 77.1, 16, 1977)

일반 설명

At first glance, it might be surprising that synthetic nonsteroidal molecules such as diethylstilbestrol (DES) could have the same activity as estradiol or other estrogens. DES can be viewed, however, as a form of estradiol with rings B and C open and a six-carbon ring D. The activity of DES analogs was explained in 1946. It was proposed that the distance between the two DES phenol OH groups was the same as the 3-OH to 17-OH distance of estradiol; therefore, they could both fit the same receptor. Medicinal chemists have shown the OH-to-OH distance to be actually 12.1 ? in DES and 10.9 ? in estradiol. In aqueous solution, however, estradiol has two water molecules that are hydrogen bonded to the 17-OH. If one of the two water molecules is included in the distance measurement, there is a perfect fit with the two OH groups of DES. This suggests that water may have an important role for estradiol in its receptor site.
It is now generally accepted that the estrogens must have a phenolic moiety for binding, but some investigators propose that the receptor may be flexible enough to accommodate varying distances between the two key hydroxyls. This point about estrogens needing a phenolic ring for high-affinity binding to the ER is critical. Steroids with a phenolic A ring and related phenolic compounds lack high-affinity binding to the other steroid hormone receptors.

일반 설명

Odorless tasteless white crystalline powder.

공기와 물의 반응

Insoluble in water.

반응 프로필

Diethylstilbestrol is incompatible with strong oxidizing agents, strong bases, acid chlorides and acid anhydrides .

화재위험

Flash point data for Diethylstilbestrol are not available; however, Diethylstilbestrol is probably combustible.

Safety Profile

Confirmed carcinogen producing skin, liver, and lung tumors in exposed humans as well as uterine and other reproductive system tumors in the female offspring of exposed women. Experimental carcinogenic, neoplas tigenic, tumorigenic, and teratogenic data. A transplacental carcinogen. A human teratogen by many routes. Poison by intraperitoneal and subcutaneous routes. It causes glandular system effects by sktn contact. Human reproductive effects by ingestion: abnormalspermatogenesis; changes in testes, epididymis, and sperm duct; menstrual cycle changes or disorders; changes in female ferulity; unspecified maternal effects; developmental abnormalities of the fetal urogenital system; germ cell effects in offspring; and delayed effects in newborn. Implicated in male impotence and enlargement of male breasts. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and fumes. See also ETHINYL ESTRADIOL.

Carcinogenicity

Diethylstilbestrol is known to be a human carcinogen based on sufficient evidence of carcinogenicity from studies in humans.

법규

Environmental Protection Agency (EPA)
Comprehensive Environmental Response, Compensation, and Liability Act Reportable quantity (RQ) = 1 lb.
Resource Conservation and Recovery Act
Listed Hazardous Waste: Waste code for which the listing is based wholly or partly on the presence of diethylstilbestrol = U089. Listed as a hazardous constituent of waste.
Food and Drug Administration (FDA)
All oral and parenteral drug products containing greater than 25 mg per unit dose of diethylstilbestrol were removed from the market because they were found to be unsafe or not effective, and they may not be compounded.
Diethylstilbestrol is prohibited from extralabel use in food-producing animals.

디에틸스틸베스트롤 준비 용품 및 원자재

원자재

준비 용품


디에틸스틸베스트롤 공급 업체

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0371-55170693
0371-55170693 info@tianfuchem.com CHINA 20672 55
Mainchem Co., Ltd.
+86-0592-6210733
+86-0592-6210733 sales@mainchem.com CHINA 32447 55
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Nanjing Finetech Chemical Co., Ltd.
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025-85710122 sales@fine-chemtech.com CHINA 892 55
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18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30001 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 sales@jushengtech.com CHINA 28236 58
Hubei xin bonus chemical co. LTD
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