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구연산 나트륨

구연산 나트륨
구연산 나트륨 구조식 이미지
카스 번호:
6132-04-3
한글명:
구연산 나트륨
동의어(한글):
구연산나트륨;구연산삼나트륨(이수화물);시트르산나트륨;구연산나트륨(SODIUMCITRATE)
상품명:
Trisodium citrate dihydrate
동의어(영문):
NATRII CITRAS;Citratic acid;CITRIC ACID H2O;CITRIC ACID MON;CITRIC ACID MONO;CITRIC ACID BP93;SodiumCitrateBp93;SODIUM CITRATE USP;SODIUM CITRATE 2H2O;CITRIC ACID BP MONO
CBNumber:
CB9752065
분자식:
C6H9Na3O9
포뮬러 무게:
294.1
MOL 파일:
6132-04-3.mol

구연산 나트륨 속성

녹는점
>300 °C(lit.)
밀도
1.76
FEMA
3026 | SODIUM CITRATE
인화점
173.9 °C
저장 조건
Store at +5°C to +30°C.
용해도
H2O: 100 mg/mL
물리적 상태
powder
색상
white
냄새
Odorless
pH 범위
7.5 - 9 at 29.4 g/l at 25 °C
수소이온지수(pH)
7.0-9.0 (25℃, 50mg/mL in H2O)
수용성
720 g/L (25 ºC)
최대 파장(λmax)
λ: 260 nm Amax: 0.01
λ: 280 nm Amax: 0.01
Merck
14,8602
BRN
6104939
안정성
Stable. Incompatible with bases, reducing agents, oxidizing agents.
InChIKey
NLJMYIDDQXHKNR-UHFFFAOYSA-K
CAS 데이터베이스
6132-04-3(CAS DataBase Reference)
EPA
1,2,3-Propanetricarboxylic acid, 2-hydroxy-, trisodium salt, dihydrate (6132-04-3)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 Xi
위험 카페고리 넘버 37/38-41-36/37/38
안전지침서 26-36/37/39-24/25-36
WGK 독일 1
RTECS 번호 GE7810000
TSCA Yes
HS 번호 2918 15 00
독성 LD50 orally in Rabbit: > 8000 mg/kg
그림문자(GHS):
신호 어:
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H319 눈에 심한 자극을 일으킴 심한 눈 손상 또는 자극성 물질 구분 2A 경고 P264, P280, P305+P351+P338,P337+P313P
예방조치문구:
P264 취급 후에는 손을 철저히 씻으시오.
P264 취급 후에는 손을 철저히 씻으시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P337+P313 눈에 대한 자극이 지속되면 의학적인 조치· 조언를 구하시오.
NFPA 704
0
1 0

구연산 나트륨 C화학적 특성, 용도, 생산

화학적 성질

white powder or colourless crystals

화학적 성질

Sodium citrate dihydrate consists of odorless, colorless, monoclinic crystals, or a white crystalline powder with a cooling, saline taste. It is slightly deliquescent in moist air, and in warm dry air it is efflorescent. Although most pharmacopeias specify that sodium citrate is the dihydrate, the USP 32 states that sodium citrate may be either the dihydrate or anhydrous material.

용도

Sodium citrate is chiefly used as a food additive, usually for flavor or as a preservative.

용도

Anticoagulant for collection of blood. In photography; as sequestering agent to remove trace metals; as emulsifier, acidulant and sequestrant in foods.

용도

An anticoagulant also used as a biological buffer

정의

ChEBI: The dihydrate of trisodium citrate.

생산 방법

Sodium citrate is prepared by adding sodium carbonate to a solution of citric acid until effervescence ceases. The resulting solution is filtered and evaporated to dryness.

Pharmaceutical Applications

Sodium citrate, as either the dihydrate or anhydrous material, is widely used in pharmaceutical formulations.
It is used in food products, primarily to adjust the pH of solutions. It is also used as a sequestering agent. The anhydrous material is used in effervescent tablet formulations. Sodium citrate is additionally used as a blood anticoagulant either alone or in combination with other citrates such as disodium hydrogen citrate.
Therapeutically, sodium citrate is used to relieve the painful irritation caused by cystitis, and also to treat dehydration and acidosis due to diarrhea.

생물학적 활성

Commonly used laboratory reagent

Safety

After ingestion, sodium citrate is absorbed and metabolized to bicarbonate. Although it is generally regarded as a nontoxic and nonirritant excipient, excessive consumption may cause gastrointestinal discomfort or diarrhea. Therapeutically, in adults, up to 15 g daily of sodium citrate dihydrate may be administered orally, in divided doses, as an aqueous solution to relieve the painful irritation caused by cystitis.
Citrates and citric acid enhance intestinal aluminum absorption in renal patients, which may lead to increased, harmful serum aluminum levels. It has therefore been suggested that patients with renal failure taking aluminum compounds to control phosphate absorption should not be prescribed citrate- or citric acid-containing products.

저장

Sodium citrate dihydrate is a stable material. Aqueous solutions may be sterilized by autoclaving. On storage, aqueous solutions may cause the separation of small, solid particles from glass containers.
The bulk material should be stored in an airtight container in a cool, dry place.

Purification Methods

Crystallise the salt from warm water by cooling to 0o. [Beilstein 3 III 1100, 3 IV 1274.]

비 호환성

Aqueous solutions are slightly alkaline and will react with acidic substances. Alkaloidal salts may be precipitated from their aqueous or hydro-alcohol solutions. Calcium and strontium salts will cause precipitation of the corresponding citrates. Other incompatibilities include bases, reducing agents, and oxidizing agents.

Regulatory Status

GRAS listed. Accepted for use as a food additive in Europe. Included in the FDA Inactive Ingredients Database (inhalations; injections; ophthalmic products; oral solutions, suspensions, syrups and tablets; nasal, otic, rectal, topical, transdermal, and vaginal preparations). Included in nonparenteral and parenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.

구연산 나트륨 준비 용품 및 원자재

원자재

준비 용품


구연산 나트륨 공급 업체

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