Chrysophanic acid
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Chrysophanic acid 속성
- 녹는점
- 194-198 °C
- 끓는 점
- 357.45°C (rough estimate)
- 밀도
- 1.2693 (rough estimate)
- 굴절률
- 1.4872 (estimate)
- 저장 조건
- Inert atmosphere,Room Temperature
- 용해도
- 클로로포름: 용해성1%
- 산도 계수 (pKa)
- 6.63±0.20(Predicted)
- 물리적 상태
- 수정 같은
- 색상
- 노란색-주황색
- 수용성
- 18°C에서 <0.1g/100mL
- 최대 파장(λmax)
- 429nm(MeOH)(lit.)
- Merck
- 14,2258
- BRN
- 1252300
- 안정성
- 안정적인. 강한 산화제와 호환되지 않습니다.
- LogP
- 4.720 (est)
- CAS 데이터베이스
- 481-74-3(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/38-36/37/38 | ||
| 안전지침서 | 26-36-37/39 | ||
| WGK 독일 | 3 | ||
| RTECS 번호 | CB6725000 | ||
| F 고인화성물질 | 8-10 | ||
| HS 번호 | 29146990 | ||
| 유해 물질 데이터 | 481-74-3(Hazardous Substances Data) |
Chrysophanic acid C화학적 특성, 용도, 생산
개요
Chrysophanol is an anthraquinone that has been found in R. palmatum and has diverse biological activities. It induces necrosis in J5 human liver cancer cells when used at concentrations of 25, 50, 75, 100, and 200 μM. Chrysophanol (5, 10, and 50 μM) reduces LPS-induced production of nitric oxide (NO) and prostaglandin E2 (PGE2; ) and inhibits LPS-induced DNA oxidation in BV-2 microglia. In vivo, chrysophanol (5 mg/kg) decreases colonic levels of IL-6 and activation of NF-κB and reduces weight loss, diarrhea, and rectal bleeding in a mouse model of colitis induced by dextran sulfate (DSS; ). Chrysophanol (0.1, 1, and 10 mg/kg) increases survival, reduces brain tissue loss, and ameliorates motor balance deficits in a mouse model of ischemia-reperfusion injury induced by middle cerebral artery occlusion (MCAO).화학적 성질
yellow crystalline solid or brown powder용도
Chrysophanic acid, a natural anthraquinone, is used to study anticancer activity in EGFR-overexpressing SNU-C5 human colon cancer cells 1. It is also used to study the inhibition of replication of poliovirus types 2 and 3 (Picornaviridae) in vitro 2.정의
ChEBI: A trihydroxyanthraquinone that is chrysazin with a methyl substituent at C-3. It has been isolated from Aloe vera and exhibits antiviral and anti-inflammatory activity.일반 설명
Golden yellow plates or brown powder. Melting point 196°C. Slightly soluble in water. Pale yellow aqueous solutions turn red on addition of alkali. Solutions in concentrated sulfuric acid are red.공기와 물의 반응
Insoluble in water.반응 프로필
Chrysophanic acid is incompatible with strong oxidizing agents.화재위험
Flash point data for Chrysophanic acid are not available; however, Chrysophanic acid is probably combustible.Purification Methods
Crystallise chrysophanic acid from EtOH or *benzene and has m 195.6-196.2o, after sublimation it in a vacuum. The yellow mono-acetate has m 188-190o (from MeOH or Me2CO). It forms Ni2+, Co2+ and Cu2+ complexes. [Beilstein 8 H 470, 8 I 725, 8 II 510, 8 III 3808, 8 IV 3277.]Chrysophanic acid 준비 용품 및 원자재
원자재
준비 용품
Chrysophanic acid 공급 업체
글로벌( 391)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +8618829768577 |
gao490372054@gamil.com | China | 1250 | 58 |
| Shaanxi Cuikang Pharmaceutical Technology Co., Ltd | +86-19164747840 +86-13119157289 |
13119157289@163.com | China | 2971 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 |
zheyansh@163.com | CHINA | 3620 | 58 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
| Shaanxi Yikanglong Biotechnology Co., Ltd. | 17791478691 |
yklbiotech@163.com | CHINA | 296 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +8618080483897 |
sales@biopurify.com | China | 3424 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28180 | 58 |
| Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
| Shaanxi Pioneer Biotech Co., Ltd . | +8613259417953 |
sales@pioneerbiotech.com | China | 3000 | 58 |