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피롤리딘

피롤리딘
피롤리딘 구조식 이미지
카스 번호:
123-75-1
한글명:
피롤리딘
동의어(한글):
피롤리딘;테트라하이드로피롤
상품명:
Pyrrolidine
동의어(영문):
PRD;PRL;NSC 62781;Azolidine;Prolamine;FEMA 2523;FEMA 3523;Lutetropin;Pyrrolidin;PYRROLIDINE
CBNumber:
CB9852978
분자식:
C4H9N
포뮬러 무게:
71.12
MOL 파일:
123-75-1.mol

피롤리딘 속성

녹는점
-63 °C
끓는 점
87-88 °C(lit.)
밀도
0.866
증기 밀도
2.45 (vs air)
증기압
128 mm Hg ( 39 °C)
굴절률
n20/D 1.443(lit.)
FEMA
3523 | PYRROLIDINE
인화점
37 °F
저장 조건
Flammables area
용해도
water: miscible
산도 계수 (pKa)
11.27(at 25℃)
물리적 상태
Liquid
수소이온지수(pH)
12.9 (100g/l, H2O, 20℃)
폭발한계
1.6-10.6%(V)
수용성
Miscible with alcohol, ether, chloroform and water.
감도
Air Sensitive
Merck
14,8015
JECFA Number
1609
BRN
102395
안정성
Stable; flammable. Incompatible with strong acids, strong oxidizing agents.
InChIKey
RWRDLPDLKQPQOW-UHFFFAOYSA-N
CAS 데이터베이스
123-75-1(CAS DataBase Reference)
NIST
Pyrrolidine(123-75-1)
EPA
Pyrrolidine(123-75-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 F,T,C
위험 카페고리 넘버 11-22-23-34-35-20/21/22-20/22-R35-R20/21/22-R11
안전지침서 16-26-36/37/39-45-33-S45-S36/37/39-S26-S16
유엔번호(UN No.) UN 1922 3/PG 2
WGK 독일 2
RTECS 번호 UX9650000
F 고인화성물질 34
자연 발화 온도 653 °F
TSCA Yes
HS 번호 2933 99 80
위험 등급 3
포장분류 II
유해 물질 데이터 123-75-1(Hazardous Substances Data)
독성 LD50 orally in Rabbit: 433 mg/kg
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H225 고인화성 액체 및 증기 인화성 액체 구분 2 위험 P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H318 눈에 심한 손상을 일으킴 심한 눈 손상 또는 자극성 물질 구분 1 위험 P280, P305+P351+P338, P310
H332 흡입하면 유해함 급성 독성 물질 흡입 구분 4 경고 P261, P271, P304+P340, P312
예방조치문구:
P210 열·스파크·화염·고열로부터 멀리하시오 - 금연 하시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P310 즉시 의료기관(의사)의 진찰을 받으시오. 삼켰다면 즉시 의료기관(의사)의 도움을 받으시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P405 밀봉하여 저장하시오.

피롤리딘 C화학적 특성, 용도, 생산

용도

의약 원료, 유기 합성, 특수 유기 용제로 사용됩니다.

외관

명확한 무색의 모빌 액, 투명 무색의 모빌 액 응용 : 제약 원료, 유기 합성, 특수 유기 해결, 제약 원료, 유기 합성, 특수 유기 해결

화학적 성질

colourless to pale yellow liquid with a penetrating

화학적 성질

Pyrrolidine has a penetrating amine-type odor, reminiscent of ammonia and piperidine. It is nauseating and diffusive

출처

Reported found in beer, bread, wheat bread, salmon caviar, fish, milk, leaves and stalks of celery, Camembert cheese, Limburger cheese, Russian cheeses, tilsit cheese, other cheeses, caviar, raw fatty fish, beer, Finnish whiskey, white wine, red wine, coffee, radish, malt, roasted peanut, sweet corn and roasted barley.

용도

A heterocyclic compound used as a building block in the synthesis of wide range of pharmaceutical compounds, namely matrix metalloprotein inhibitors (MMPIs) and aminopeptidase N inhibitors (APNIs).

용도

Uses of this compound in any major scalehave not been made. It occurs in tobacco andcarrot leaves. It is formed by reduction ofpyrrole.

정의

pyrrolidine: A saturated heterocycliccompound having one nitrogenatom in a five-membered ring,C4H9N; r.d. 0.87; m.p. –63°C b.p.87°C. It is found in certain plants andthe ring structure is present in manyalkaloids.

정의

ChEBI: A cyclic amine whose five-membered ring contains four carbon atoms and one nitrogen atom; the parent compound of the pyrrolidine family.

제조 방법

Via overall 5-endo-trig cyclizations of homoallylic tosylamides.

Aroma threshold values

Detection: 20.2 ppm

Taste threshold values

Taste characteristics at 50 ppm: ammonia and fishy, amine-like with seaweed and shellfish nuances.

일반 설명

A colorless to pale yellow liquid with an ammonia-like odor. Flash point 37°F. Density 0.85 g / cm3. Vapors heavier than air. Produces toxic oxides of nitrogen during combustion.

공기와 물의 반응

Highly flammable. Very soluble in water.

반응 프로필

Tetrahydro pyrrole neutralizes acids in exothermic reactions to form salts plus water. May be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. May generate hydrogen, a flammable gas, in combination with strong reducing agents such as hydrides. An explosion occurred when a mixture of Tetrahydro pyrrole, benzaldehyde, and propionic acid was heated in an attempt to form porphyrins.

위험도

Flammable, dangerous fire risk. Toxic by ingestion and inhalation.

건강위험

The acute toxicity of pyrrolidine is moderateon test animals. It is somewhat less toxicthan pyrrole. The vapors are an irritant tothe eyes and respiratory tract. The liquid iscorrosive to the skin. Contact with the eyescan cause damage. The oral LD50 value inrats is 300 mg/kg, while the inhalation LC50value in mice is 1300 mg/m3/2 h (NIOSH1986).

건강위험

May cause toxic effects if inhaled or ingested/swallowed. Contact with substance may cause severe burns to skin and eyes. Fire will produce irritating, corrosive and/or toxic gases. Vapors may cause dizziness or suffocation. Runoff from fire control or dilution water may cause pollution.

화재위험

Flammable/combustible material. May be ignited by heat, sparks or flames. Vapors may form explosive mixtures with air. Vapors may travel to source of ignition and flash back. Most vapors are heavier than air. They will spread along ground and collect in low or confined areas (sewers, basements, tanks). Vapor explosion hazard indoors, outdoors or in sewers. Runoff to sewer may create fire or explosion hazard. Containers may explode when heated. Many liquids are lighter than water.

Safety Profile

Poison by ingestion and intravenous routes. Moderately toxic by inhalation. Dangerous fire hazard when exposed to heat or flame; can react vigorously with oxidizing materials. To fight fire, use alcohol foam, CO2, dry chemical. When heated to decomposition it emits hghly toxic fumes of NOx.

효소 저해제

This colorless liquid (FWfree-base = 71.122 g/mol; B.P. = 88.5-89°C), also known as tetrahydropyrrole, is the structural foundation of many biomolecules, including proline. Pyrrolidine has also been reported in tobacco and carrot leaves. Pyrrolidine is miscible in water and is a strong base (pKa = 11.27 at 25°C). Target (s) : D-amino-acid oxidase, weakly inhibited; and prolyl-tRNA synthetase.

Purification Methods

Dry pyrrolidine with BaO or sodium, then fractionally distil it, under N2, through a Todd column (p 11) packed with glass helices. [Beilstein 20 H 159, 20 I 36, 20 II 79, 20 III/IV 2072, 20/1 V 162.]

피롤리딘 준비 용품 및 원자재

원자재

준비 용품


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