2-Chlorotrityl chloride
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2-Chlorotrityl chloride 속성
- 녹는점
- 130-135 °C
- 끓는 점
- 421.3±40.0 °C(Predicted)
- 밀도
- 1.222±0.06 g/cm3(Predicted)
- 저장 조건
- 2-8°C
- 용해도
- 클로로포름, 메탄올, 디클로로메탄에 용해되고 물에는 용해되지 않습니다.
- 물리적 상태
- 가루
- 색상
- 담황색 결정성 분말
- BRN
- 1983914
- CAS 데이터베이스
- 42074-68-0(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | Xi | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 36/37/38 | ||
| 안전지침서 | 26-24/25-22 | ||
| 유엔번호(UN No.) | 3261 | ||
| WGK 독일 | 3 | ||
| F 고인화성물질 | 10-21 | ||
| HS 번호 | 2903 99 80 | ||
| 위험 등급 | 8 | ||
| 포장분류 | III |
2-Chlorotrityl chloride C화학적 특성, 용도, 생산
화학적 성질
off-white to yellow or brown beads용도
2-Chlorotrityl chloride is used as an intermediate of clotrimazole. It is also used in the preparation of modified trityl nucleosides as inhibitors of P. falciparum dUTPase. In addition, it serves as a protecting group reagent for carboxylic acids forming esters.주요 응용
2-Chlorotrityl Chloride is used in convergent peptide synthesis. Extremely acid labile resin for preparing peptide acids and partially protected peptide fragments by the Fmoc strategy. Cleavage can be effected by using AcOH/TFE/DCM or 0.5% TFA.제조 방법
2-Chlorotrityl chloride synthesis: It is esterified with 2-Chlorobenzoic acid and ethanol in the presence of sulfuric acid or p-toluenesulfonic acid to generate Ethyl 2-Chlorobenzoate, which is then condensed with phenylmagnesium bromide (Grignard reaction) to obtain (2-Chlorophenyl)diphenylmethanol magnesium salt is hydrolyzed with sulfuric acid to obtain (2-Chlorophenyl)diphenylmethanol, which is then chlorinated with thionyl chloride to obtain the product.Biotechnological Applications
The 2-chlorotrityl chloride (2-CTC) resin is one of the most frequently used and most versatile resins for the large-scale manufacture of peptides. It is slightly less acid-labile than Trityl Resin and thus more widely used in solid phase peptide synthesis. Peptides UBI-8 and UBI-9 were synthesized by Fmoc-solid phase chemistry using a 2-chlorotrityl chloride linker-resin. Trityl linkers have certain advantages in comparison to the alkoxybenzyl alcohol (eg. Wang resin), especially in the area of peptide chemistry. First, the problem of racemization during the loading of the first amino acid (using DIPEA) is avoided with trityl linkers. Second, due to steric factors, no diketopiperazine formation is observed.2-Chlorotrityl chloride 준비 용품 및 원자재
원자재
Ethyl 2-Chlorobenzoate
브로모벤젠
2-클로로벤조익산
PARA TOLUENE
마그네슘메틸레이트
벤즈히드롤
염화 티오닐
CLOTRIMAZOLE IMP. A (PHARMEUROPA): (2-CHLOROPHENYL)DIPHENYLMETHANOL
Methyl 2-chlorobenzoate
o-클로로벤조트리클로라이드
준비 용품
2-Chlorotrityl chloride 공급 업체
글로벌( 339)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Hebei Zhanyao Biotechnology Co. Ltd | 15369953316 +8615369953316 |
admin@zhanyaobio.com | China | 2136 | 58 |
| Chemtour Biotech Co., Ltd | +8617327281506 |
market@chemtour.com | China | 1472 | 58 |
| Shanghai Qyubiotech Co., Ltd. | +86-086-021-37596619 +8618019359838 |
info@qyubiotech.com | China | 299 | 58 |
| Henan Bao Enluo International TradeCo.，LTD | +86-17331933971 +86-17331933971 |
deasea125996@gmail.com | China | 2503 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7786 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21691 | 55 |
| Nanjing ChemLin Chemical Industry Co., Ltd. | 025-83697070 |
product@chemlin.com.cn | CHINA | 3012 | 60 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 |
sales@coreychem.com | China | 29914 | 58 |
2-Chlorotrityl chloride 관련 검색:
아세틸아세톤산 구리 실버 아세틸아세토네이트 알루미늄 아세틸아세토네이트 디스프로슘 트리(2,2,6,6-테트라메틸-3,5-헵탄디오네이트) 아세틸아세토산 제2철 코발트(II) 아세틸아세토네이트 하이드레이트 메탄 디페닐메탄 폴리스티렌
Tris(2,4-pentanedionato)chroMiuM(III)
SALCOMINE
Benzyl isocyanide
PHENYLSELENOL
METHYL ISOCYANOACETATE
N-BUTYLISOCYANIDE
TERT-BUTYL ISOCYANIDE
TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III)
1,1,3,3-TETRAMETHYLBUTYL ISOCYANIDE