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디메틸설페이트

디메틸설페이트
디메틸설페이트 구조식 이미지
카스 번호:
77-78-1
한글명:
디메틸설페이트
동의어(한글):
다이메틸황산염;디메틸설페이트;디메틸황산;황산,디메틸에스테르(SULFURICACID,DIMETHYLESTER)황산디메틸(DIMETHYLSULPHATE)메틸황산염(METHYLSULFATE)RCRAU103STCC4933322;황산디메틸;황산이메틸;황산,디메틸에스테르;메틸황산염;다이메칠설페이트
상품명:
Dimethyl sulfate
동의어(영문):
NSC 56194;ai3-52118;Methanesulfate;Dimethylsulfat;Dimetilsolfato;METHYL SULFATE;Methylsulphate;Dimethylsulfaat;DIMETHYL SULFATE;sulfatedemethyle
CBNumber:
CB9854316
분자식:
C2H6O4S
포뮬러 무게:
126.13
MOL 파일:
77-78-1.mol

디메틸설페이트 속성

녹는점
-32 °C
끓는 점
188 °C(lit.)
밀도
1.333 g/mL at 25 °C(lit.)
증기 밀도
4.3 (vs air)
증기압
0.7 mm Hg ( 25 °C)
굴절률
n20/D 1.386(lit.)
인화점
182 °F
저장 조건
2-8°C
용해도
ethanol: 0.26 g/mL, clear, colorless
물리적 상태
Liquid
색상
Clear colorless
냄새
Almost odorless
수용성
2.8 g/100 mL (18 ºC)
Merck
13,3282
BRN
635994
노출 한도
TLV/PEL-TWA skin 0.1 ppm (0.52 mg/m3 ) (ACGIH, OSHA, NIOSH) IDLH 10 ppm (NIOSH).
안정성
Stable; combustible. Incompatible with strong oxidizing agents, strong bases including ammonia. Moisture-sensitive.
CAS 데이터베이스
77-78-1(CAS DataBase Reference)
NIST
Sulfuric acid, dimethyl ester(77-78-1)
EPA
Sulfuric acid, dimethyl ester(77-78-1)
안전
  • 위험 및 안전 성명
  • 위험 및 사전주의 사항 (GHS)
위험품 표기 T+
위험 카페고리 넘버 45-25-26-34-43-68
안전지침서 53-45-61
유엔번호(UN No.) UN 1595 6.1/PG 1
WGK 독일 2
RTECS 번호 WS8225000
F 고인화성물질 21
자연 발화 온도 495 °C
위험 등급 6.1(a)
포장분류 I
HS 번호 29209090
유해 물질 데이터 77-78-1(Hazardous Substances Data)
독성 LD50 orally in rats: 440 mg/kg (Smyth)
그림문자(GHS):
신호 어: Danger
유해·위험 문구:
암호 유해·위험 문구 위험 등급 범주 신호 어 그림 문자 P- 코드
H301 삼키면 유독함 급성 독성 물질 - 경구 구분 3 위험 P264, P270, P301+P310, P321, P330,P405, P501
H314 피부에 심한 화상과 눈에 손상을 일으킴 피부부식성 또는 자극성물질 구분 1A, B, C 위험 P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H317 알레르기성 피부 반응을 일으킬 수 있음 피부 과민성 물질 구분 1 경고 P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H330 흡입하면 치명적임 급성 독성 물질 흡입 구분 1, 2 위험 P260, P271, P284, P304+P340, P310,P320, P403+P233, P405, P501
H341 유전적인 결함을 일으킬 것으로 의심됨 (노출되어도 생식세포 유전독성을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 생식세포 변이원성 물질 구분 2 경고 P201,P202, P281, P308+P313, P405,P501
H350 암을 일으킬 수 있음 (노출되어도 암을 일으키지 않는다는 결정적인 증거가 있는 노출경로가 있다면 노출경로 기재) 발암성 물질 구분 1A, 1B 위험
예방조치문구:
P201 사용 전 취급 설명서를 확보하시오.
P260 분진·흄·가스·미스트·증기·...·스프레이를 흡입하지 마시오.
P280 보호장갑/보호의/보안경/안면보호구를 착용하시오.
P303+P361+P353 피부(또는 머리카락)에 묻으면 오염된 모든 의복은 벗거나 제거하시오 피부를 물로 씻으시오/샤워하시오.
P305+P351+P338 눈에 묻으면 몇 분간 물로 조심해서 씻으시오. 가능하면 콘택트렌즈를 제거하시오. 계속 씻으시오.
P308+P313 노출 또는 접촉이 우려되면 의학적인 조치· 조언를 구하시오.
P403+P233 용기는 환기가 잘 되는 곳에 단단히 밀폐하여 저장하시오.

디메틸설페이트 MSDS


Dimethyl sulfate

디메틸설페이트 C화학적 특성, 용도, 생산

화학적 성질

colourless liquid

용도

Dimethyl Sulfate is a diester of methanol and sulfuric acid. Dimethyl Sulfate is commonly used as a reagent for the methylation of phenols, amines, and thiols. Dimethyl Sulfate is an effective and widely used probe for sequence-specific protein-DNA interactions

용도

Methylating agent in the manufacture of many organic chemicals. War gas.

용도

Diethyl sulfate is used as an ethylating agentin many organic syntheses. It is also usedas an accelerator in the sulfation of ethyleneand as an intermediate in certain sulfonationreactions (Merck 1996).

용도

It is used as a methylating agent in themanufacture of many organic compounds,such as, phenols and thiols. Also, it is used inthe manufacture of dyes and perfumes, andas an intermediate for quaternary ammoniumsalts. It was used in the past as a militarypoison.

정의

ChEBI: The dimethyl ester of sulfuric acid.

일반 설명

Dimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. Dimethyl sulfate is very toxic by inhalation. Dimethyl sulfate is a combustible liquid and has a flash point of 182°F. Dimethyl sulfate is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. Dimethyl sulfate is corrosive to metals and tissue.

공기와 물의 반응

Water soluble.

반응 프로필

Pure Dimethyl sulfate and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as Dimethyl sulfate, [MCA Case History No. 1786].

건강위험

Acute: extremely toxic vapors and liquid -- a few whiffs or contact on skin could be fatal. Also acutely toxic if ingested. Delayed effects which are ultimately fatal may also occur. Lethal concentrations as low as 97 ppm/10 min have been reported in humans. DNA inhibition and damage to human somatic cells, and sister chromatid exchange in human fibroblast cells were observed. Delayed appearance of symptoms may permit unnoticed exposure to lethal quantities.

건강위험

Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. Ingestion of dimethyl sulfate causes burns to the mouth, throat, and gastrointestinal tract. The effects of overexposure to dimethyl sulfate vapor may be delayed. After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Fatal pulmonary edema may develop. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. It is a strong alkylating agent and does produce genetic damage in animals and in bacterial and mammalian cell cultures.

건강위험

The toxicity of this compound is significantlylower than that of the corresponding methylester. The occupational hazard from inhala-tion is lower because of its lower vaporpressure. A 4-hour exposure to 250 ppmproved lethal to rats. Inhalation toxicity datain humans are unavailable. It is, however, asevere skin irritant. Such action on skin maybe attributed to its gradual decomposition tosulfuric acid upon contact with moisture inskin. Contact of the liquid or the vapor onthe eye can produce severe irritation. It ismoderately toxic by ingestion.
LD50 oral (mouse): ~650 mg/kg
LD50 skin (rabbit): 600 mg/kg
There is no evidence of its carcinogenicpotency in humans. However, on the basis ofits alkylating properties similar to dimethylsulfate and other alkylating agents, this sub-stance may be reasonably anticipated tocause cancer.

화재위험

Flash Point (°F): 240 ℃; 182 ℃; Flammable Limits in Air (%): Data not available; Fire Extinguishing Agents: Water, foam, carbon dioxide, or dry chemical; Fire Extinguishing Agents Not To Be Used: Not pertinent; Special Hazards of Combustion Products: Flammable, toxic vapors generated; Behavior in Fire: Not pertinent; Ignition Temperature (°F): 370; Electrical Hazard: Not pertinent; Burning Rate: Data not available.

화재위험

Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.

화재위험

Material is normally stable even under fire exposure conditions and is not hazardously reactive with water. Dimethyl sulfate is incompatible with strong oxidizers and strong ammonia solutions.

인화성 및 폭발성

Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.

화학 반응

Reactivity with Water Slow, non-hazardous reaction; Reactivity with Common Materials: Corrodes metal when wet; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Sodium bicarbonate or lime; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.

Safety Profile

Confirmed carcinogen with experimental carcinogenic, tumorigenic, and teratogenic data. Human poison by inhalation. Experimental poison by ingestion, inhalation, intravenous, and subcutaneous routes. Other experimental reproductive effects. Human mutation datareported. A corrosive irritant to skin, eyes, and mucous membranes. There is no odor or initial irritation to give warning of exposure. On brief, dd exposures, conjunctivitis, catarrhal inflammation of the mucous membranes of the nose, throat, larynx, and trachea, and possibly some reddening of the skin develop after the latent period. With longer, heavier exposures, the cornea shows clouding, the irritation changes to the nasopharynx are more marked, and after 6 to 8 hours pulmonary edema may develop. Death may occur in 3 or 4 days. The liver and kidneys are frequently damaged. Spang of the liquid on the skin can cause ulceration and localnecrosis. In patients surviving severe exposure, there may be serious injury of the liver and hdneys, with suppression of urine, jaunlce, albuminuria, and hematuria appearing. Death, resulting from the hdney or liver damage, may be delayed for several weeks. Flammable when exposed to heat, flame, or oxidizers. Can react with oxidizing materials. Violent reaction with NH4OH and NaN3. To fight fire, use water, foam, CO2, dry chemical. When heated to decomposition it emits toxic fumes of SOx See also SULFATES.

저장

work with dimethyl sulfate should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn at all times to prevent skin and eye contact.

비 호환성

Dimethyl sulfate can react violently with ammonium hydroxide, sodium azide, and strong oxidizers.

폐기물 처리

Excess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.

디메틸설페이트 준비 용품 및 원자재

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