디메틸설페이트
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디메틸설페이트 속성
- 녹는점
- -32 °C
- 끓는 점
- 188 °C(lit.)
- 밀도
- 1.333 g/mL at 25 °C(lit.)
- 증기 밀도
- 4.3 (vs air)
- 증기압
- 0.7 mm Hg ( 25 °C)
- 굴절률
- n
20/D 1.386(lit.)
- 인화점
- 182 °F
- 저장 조건
- 2-8°C
- 용해도
- 에탄올: 0.26 g/mL, 투명, 무색
- 물리적 상태
- 액체
- 색상
- 무색의
- 냄새
- 거의 무취
- 수용성
- 2.8g/100mL(18℃)
- Merck
- 13,3282
- BRN
- 635994
- 노출 한도
- TLV/PEL-TWA skin 0.1 ppm (0.52 mg/m3 ) (ACGIH, OSHA, NIOSH) IDLH 10 ppm (NIOSH).
- Dielectric constant
- 55.0(20℃)
- 안정성
- 안정적인; 타기 쉬운. 암모니아를 포함한 강산화제, 강염기와 호환되지 않습니다. 습기에 민감합니다.
- CAS 데이터베이스
- 77-78-1(CAS DataBase Reference)
- IARC
- 2A (Vol. 4, Sup 7, 71) 1999
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | T+ | ||
---|---|---|---|
위험 카페고리 넘버 | 45-25-26-34-43-68 | ||
안전지침서 | 53-45-61 | ||
유엔번호(UN No.) | UN 1595 6.1/PG 1 | ||
WGK 독일 | 2 | ||
RTECS 번호 | WS8225000 | ||
F 고인화성물질 | 21 | ||
자연 발화 온도 | 495 °C | ||
위험 등급 | 6.1(a) | ||
포장분류 | I | ||
HS 번호 | 29209090 | ||
유해 물질 데이터 | 77-78-1(Hazardous Substances Data) | ||
독성 | LD50 orally in rats: 440 mg/kg (Smyth) | ||
IDLA | 7 ppm | ||
기존화학 물질 | KE-32593 | ||
유해화학물질 필터링 | 97-1-406 | ||
중점관리물질 필터링 | 별표1-20 | ||
함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 황산 디메틸 및 이를 0.1% 이상 함유한 혼합물 |
디메틸설페이트 C화학적 특성, 용도, 생산
개요
Dimethyl sulfate is a colorless, oily liquid with a faint, onionlike odor. It is soluble in water, ether, dioxane, acetone, benzene, and other aromatic hydrocarbons, miscible with ethanol, and sparingly soluble in carbon disulfide. It is stable under normal temperatures and pressures, but hydrolyzes rapidly in water at or above 18 ℃.Dimethyl sulfate has been produced commercially since at least the 1920s. One production method is continuous reaction of dimethyl ether with sulfur trioxide. In 2009, dimethyl sulfate was produced by 33 manufacturers worldwide, including 1 in the United States, 14 in China, 5 in India, 5 in Europe, 6 in East Asia, and 2 in Mexico, and was available from 44 suppliers, including 16 US suppliers. There are no data on US imports or exports of dimethyl sulfate. Reports filed from 1986 through 2002 under the US Environmental Protection Agency’s Toxic Substances Control Act Inventory Update Rule indicate that US production plus imports of dimethyl sulfate totaled 10–50 million pounds. The simplest way of synthesizing dimethyl sulfate is by esterification of sulfuric acid with methanol as follows:2CH3OH+ H2SO4→(CH3)2SO4 + 2H2O
화학적 성질
Dimethyl sulfate is essentially odorless. The specific gravity of this colorless, corrosive, oily liquid is 1.3322 g/cm3. Dimethyl sulfate is soluble in ether, dioxane, acetone, benzene, and other aromatic hydrocarbons. It is sparingly soluble in carbon disulfide and aliphatic hydrocarbons, and only slightly soluble in water (28 g/l at 18 °C) (O'Neil, 2006).용도
Dimethyl sulfate is a strong alkylating agent and might also react with the carboxylic acid substrate, further reducing the DMS concentration in the mixture. It is used as a methylating agent in themanufacture of many organic compounds,such as, phenols and thiols. Also, it is used inthe manufacture of dyes and perfumes, andas an intermediate for quaternary ammoniumsalts. It was used in the past as a militarypoison.주요 응용
Dimethyl Sulfate is a diester of methanol and sulfuric acid. Dimethyl Sulfate is commonly used as a reagent for the methylation of phenols, amines, and thiols. Dimethyl Sulfate is an effective and widely used probe for sequence-specific protein-DNA interactions.정의
ChEBI: Dimethyl sulfate is the dimethyl ester of sulfuric acid. It has a role as an alkylating agent and an immunosuppressive agent.제조 방법
Dimethyl sulfate is prepared by distillation of an oleum/methanol mixture; technical production using dimethyl ether and SO3 has also been reported (NLM, 2013).일반 설명
Dimethyl sulfate is a colorless oily liquid, odorless to a faint onion-like odor. Dimethyl sulfate is very toxic by inhalation. Dimethyl sulfate is a combustible liquid and has a flash point of 182°F. Dimethyl sulfate is slightly soluble in water and decomposed by water to give sulfuric acid with evolution of heat. Dimethyl sulfate is corrosive to metals and tissue.공기와 물의 반응
Water soluble.반응 프로필
Pure Dimethyl sulfate and concentrated aqueous ammonia react extremely violently with one another, as is the case for tertiary organic bases, [NFPA 491M, 1991]. Dimethyl sulfate ignites in contact with unheated barium chlorite, due to the rapid formation of unstable methyl chlorite. The product of methylating an unnamed material at 110°C was alloyed to remain in a reactor for 80 min. before the reactor exploded. This involved a sulfur ester such as Dimethyl sulfate, [MCA Case History No. 1786].건강위험
Dimethyl sulfate is extremely hazardous because of its lack of warning properties and delayed toxic effects. The vapor of this compound is extremely irritating to the skin, eyes, and respiratory tract, and contact with the liquid can cause very severe burns to the eyes and skin. Ingestion of dimethyl sulfate causes burns to the mouth, throat, and gastrointestinal tract. The effects of overexposure to dimethyl sulfate vapor may be delayed. After a latent period of 10 hours or more, headache and severe pain to the eyes upon exposure to light may occur, followed by cough, tightness of the chest, shortness of breath, difficulty in swallowing and speaking, vomiting, diarrhea, and painful urination. Fatal pulmonary edema may develop. Systemic effects of dimethyl sulfate include damage to the liver and kidneys. Dimethyl sulfate is listed by IARC in Group 2A ("probable human carcinogen") and is classified as a "select carcinogen" under the criteria of the OSHA Laboratory Standard. Data indicate that dimethyl sulfate does not specifically harm unborn animals; dimethyl sulfate is not a developmental toxin. It is a strong alkylating agent and does produce genetic damage in animals and in bacterial and mammalian cell cultures.인화성 및 폭발성
Dimethyl sulfate is a combustible liquid (NFPA rating = 2). Toxic dimethyl sulfate vapors are produced in a fire. Carbon dioxide or dry chemical extinguishers should be used to fight dimethyl sulfate fires.Carcinogenicity
Dimethyl sulfate is reasonably anticipated to be a human carcinogenbased on sufficient evidence of carcinogenicity from studies in experimental animals.환경귀착
Chemical/Physical. Hydrolyzes in water (half-life = 1.2 h) to methanol and sulfuric acid (Robertson and Sugamori, 1966) via the intermediate methyl sulfuric acid (Du Pont, 1999a)저장
work with dimethyl sulfate should be conducted in a fume hood to prevent exposure by inhalation, and appropriate impermeable gloves and safety goggles should be worn at all times to prevent skin and eye contact.비 호환성
Dimethyl sulfate can react violently with ammonium hydroxide, sodium azide, and strong oxidizers.폐기물 처리
Excess dimethyl sulfate and waste material containing this substance should be placed in a covered metal container, clearly labeled, and handled according to your institution's waste disposal guidelines.디메틸설페이트 준비 용품 및 원자재
원자재
준비 용품
Cationic Brilliant Blue RL
2,4,5-Trimethoxynitrobenzene
3'-DIMETHYLAMINOACETOPHENONE
3,5-DIBROMO-2-METHOXYBENZALDEHYDE
2,5-Dimethoxy-4-chloroaniline
3,4,5-TRIMETHOXYBENZHYDRAZIDE
3-디메틸아미노안식향산
Fursultiamine
Aminopyrine
BENZOIC 2-BENZOYL-1,2-DIMETHYLHYDRAZIDE
2-(4-(ACETYLAMINO)PHENYL)PROPIONITRILE
6-AMINO-2-METHYLTHIO-3-METHYLURACIL
o-Anisic acid
3,5-Dimethoxybenzoic acid
2-(4-Nitrophenyl)propiononitrile
5-(Dimethylamino)-1-naphthalenesulfonic acid
SCOPARONE
2-(4-aminophenyl)propiononitrile
antistatic Agent TM
Cationic surface active agent
trimethyl lauroylaminopropyl ammonium methylsulfate
2,4-Dimethoxybenzoic acid
비페나제이트
4-METHYLDIBENZOTHIOPHENE
α-Dimethoxymethyl-methoxypropionitrile
Methyl 4-acetamido-5-chloro-2-methoxybenzoate
Methyl 4-acetamido-2-methoxybenzoate
1-CHLOROMETHYL-2,3,4-TRIMETHOXYBENZENE
3,4-DIHYDROXY-5-METHOXYBENZOIC ACID METHYL ESTER
5-Chloro-2-(methylamino)benzophenone
7-METHYLGUANINE
2-(METHYLTHIO)BENZOIC ACID
softening CS
[3R-(3α,3aβ,6β,7β,8aα)]-옥타하이드로-6-메톡시-3,6,8,8-테트라메틸-1H-3a,7-메타노아줄렌
1-METHYL-5-NITROIMIDAZOLE
2-(4-ACETAMINO-3-CHLOROPHENYL)PROPIONITRILE
Methyl trifluoromethanesulfonate
7-METHOXY-3,4,5,6-TETRAHYDRO-2H-AZEPINE
2-하이드록시-4-메톡시벤조페논
5-Chloro-2-methoxybenzoic acid
디메틸설페이트 공급 업체
글로벌( 346)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Shandong Dexiang International Trade Co., Ltd | 15662695772;+8615662691337 |
sales006@dexiangchemical.com | China | 998 | 58 |
Wuhan Boyuan Import & Export Co., LTD | +8615175982296 |
Mike@whby-chem.com | China | 974 | 58 |
Hebei Mojin Biotechnology Co., Ltd | +8613288715578 |
sales@hbmojin.com | China | 12453 | 58 |
Hebei Yanxi Chemical Co., Ltd. | +8617531190177 |
peter@yan-xi.com | China | 5993 | 58 |
Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 |
info@fdachem.com | China | 7377 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29797 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21695 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32480 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 |
info@tnjchem.com | China | 2989 | 55 |
Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 |
alice@crovellbio.com | China | 8822 | 58 |