모노클로로아세트산메틸
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모노클로로아세트산메틸 속성
- 녹는점
- -33 °C
- 끓는 점
- 130 °C740 mm Hg(lit.)
- 밀도
- 1.238 g/mL at 25 °C(lit.)
- 증기 밀도
- 3.8 (vs air)
- 증기압
- 10 mm Hg ( 25 °C)
- 굴절률
- n
20/D 1.422(lit.)
- 인화점
- 125 °F
- 저장 조건
- Store at <= 20°C.
- 용해도
- 51.6g/l(느린 분해)
- 물리적 상태
- 액체
- 색상
- 무색의
- 수소이온지수(pH)
- 4.6 (28g/l, H2O, 20℃)
- 폭발한계
- 4.6-18.5%(V)
- 수용성
- 28g/L(20℃)
- Merck
- 14,6042
- BRN
- 506255
- Dielectric constant
- 12.9（20℃）
- LogP
- 0.63 at 20℃
- CAS 데이터베이스
- 96-34-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| 위험품 표기 | T,Xi,F | ||
|---|---|---|---|
| 위험 카페고리 넘버 | 10-23/25-37/38-41-40-36/37/38-38 | ||
| 안전지침서 | 26-37/39-45-36-16 | ||
| 유엔번호(UN No.) | UN 2295 6.1/PG 1 | ||
| WGK 독일 | 2 | ||
| RTECS 번호 | AF9500000 | ||
| F 고인화성물질 | 19 | ||
| 자연 발화 온도 | 869 °F | ||
| TSCA | Yes | ||
| HS 번호 | 2915 40 00 | ||
| 위험 등급 | 6.1 | ||
| 포장분류 | I | ||
| 유해 물질 데이터 | 96-34-4(Hazardous Substances Data) | ||
| 독성 | LD50 orally in Rabbit: 107 mg/kg | ||
| 기존화학 물질 | KE-05494 | ||
| 유해화학물질 필터링 | 97-1-82 | ||
| 함량 및 규제정보 | 물질구분: 유독물질; 혼합물(제품)함량정보: 메틸 클로로아세트산 및 이를 25% 이상 함유한 혼합물 |
모노클로로아세트산메틸 C화학적 특성, 용도, 생산
화학적 성질
clear colorless liquid with a slight irritating odor. It is miscible with organic solvents such as ethanol, ether, acetone and benzene. Slightly soluble in water.용도
Methyl chloroacetate is used as a solvent and chemical intermediate. It acts as a precursor in the preparation of (carboxymethyl) trimethylammonium chloride esters. Further, it is used in the preparation of octakis-(carbethoxymethoxy)calix[8]arene. It is employed as an extraction solvent during the separation of neutral compounds. In addition to this, it is used in the synthesis of dimethyl carbonate.주요 응용
Methyl chloroacetate (MC) is a halogenated ester mainly used as a solvent in organic synthesis or in the preparation of several compounds. Typically, MC is used in the preparation of (carboxymethyl) trimethylammonium chloride estersor in the synthesis of octakis- (carbethoxymethoxy)calix[8]arene. Additionally, methyl chloroacetate acts as an extraction solvent during the separation of neutral compounds with concentration enhancement using coupling liquid–liquid semi-microextraction with micellar electrokinetic chromatography through oncapillary decomposition.제조 방법
Methyl chloroacetate is prepared by esterification of chloroacetic acid with methanol.Reaction: Methanol and chloroacetic acid are uniformly mixed in a weight ratio of 0.366:1, heated with stirring, and the esterification reaction is carried out at 105-110 °C. In the reaction process, the ternary azeotrope of methyl chloroacetate, water and methanol is continuously steamed, layered through the ester separator, the separated methanol and water are returned to the reaction pot, and the separated crude ester is made of sodium carbonate. neutralize. The neutralized crude ester is firstly cut out the 130°C fraction by atmospheric distillation, and then subjected to vacuum distillation to collect the 65°C (8kPa) fraction, which is the finished product of methyl chloroacetate. The yield is about 96%.
일반 설명
A crystalline solid or a solid dissolved in a liquid. Insoluble in water and denser than water. Contact may slightly irritate skin, eyes and mucous membranes. May be slightly toxic by ingestion. Used to make other chemicals.공기와 물의 반응
Highly flammable. Insoluble in water.반응 프로필
Methyl chloroacetate is a halogenated ester. Esters react with acids to liberate heat along with alcohols and acids. Strong oxidizing acids may cause a vigorous reaction that is sufficiently exothermic to ignite the reaction products. Heat is also generated by the interaction of esters with caustic solutions. Flammable hydrogen is generated by mixing esters with alkali metals and hydrides.위험도
Toxic by ingestion and inhalation.건강위험
Extremely corrosive to the eyes, skin, nose, throat, and upper respiratory tract. Inhalation may be fatal as a result of spasm, inflammation and edema of the larynx and bronchi, chemical pneumonitis, and pulmonary edema. Symptoms of exposure include burning sensation, coughing, wheezing, laryngitis, shortness of breath, headache, nausea, and vomiting.화재위험
Special Hazards of Combustion Products: Toxic fumes of hydrogen chlorideSafety Profile
Poison by ingestion. Moderately toxic by inhalation and subcutaneous routes. Flammable when exposed to heat or flame; can react vigorously with oxidizing materials. When heated to decomposition it emits toxic fumes of Cl-.Purification Methods
Shake the ester with saturated aqueous Na2CO3 (three times), aqueous 50% CaCl2 (three times), saturated aqueous NaCl (twice), dry (Na2SO4) and fractionally distil it. Very toxic. [Beilstein 2 IV 480.]모노클로로아세트산메틸 준비 용품 및 원자재
원자재
준비 용품
3-Cyanomethylthiophene
디메토에이트
Thiophene-3-ethanol
METHYL 3-METHYL-2-FUROATE
3-티오펜아세트산
1,2-DIHYDRO-4-(METHOXYMETHYL)-6-METHYL-5-NITRO-2-OXONICOTINONITRILE
2-오소-1-피리딘아세트아마이드;피라세탐
(4,6-DIMETHYL-PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE
NOCODAZOLE
QUINTIOPHOS
O,O-DIMETHYL-S-(METHOXY-CARBONYL) THIOPHOSPHATE
CHLOROMETHYLACETAMIDE
글라이신아마이드에이치씨엘
THIOPHEN-3-YL-ACETYL CHLORIDE
2-METHOXYPHENOXYACETIC ACID
오메토산
METHYL 3-(6-METHOXY-2-NAPHTHYL)-3-METHYL GLYCIDATE
2-HYDROXYPYRAZINE
2-PIPERAZIN-1-YL-ACETAMIDEHYDROCHLORIDE
3-Methyl-2-furoic acid
2-Bromo-5-fomylthiazole
Methyl methoxyacetate
Methyl [(dimethoxyphosphinothioyl)thio]acetate
메틸 플루오로아세테이트
시안초산메틸
모노클로로아세트산메틸 공급 업체
글로벌( 378)공급 업체
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