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methysergide

methysergide 구조식 이미지

카스 번호:: 361-37-5

상품명:: methysergide

동의어(영문):: C07199;UML-491;UML 491;Deseril;Desernyl;Methysergid;methysergide;Methylergometrine maleate EP Impurity G;9,10-Didehydro-N-[(S)-1-(hydroxymethyl)propyl]-1,6-dimethylergoline-8β-carboxamide;Ergoline-8-carboxamide,9,10-didehydro-N-[(1S)-1-(hydroxymethyl)propyl]-1,6-dimethyl-, (8b)-

CBNumber:: CB9910759

분자식:: C21H27N3O2

포뮬러 무게:: 353.46

MOL 파일:: 361-37-5.mol

속성

안전

용도

공급 업체 10

methysergide 속성

녹는점: 194-196°

알파: D20 -45° (c = 0.5 in pyridine)

끓는 점: 486.87°C (rough estimate)

밀도: 1.1377 (rough estimate)

굴절률: 1.6300 (estimate)

저장 조건: Amber Vial, -20°C Freezer, Under inert atmosphere

용해도: 클로로포름(약간), 메탄올(약간), 피리딘(약간)에 용해됨

물리적 상태: 고체

물리적 상태: 단단한 모양

산도 계수 (pKa): pKa 6.62± 0.02(H2O,t =24,I<0.01)(Approximate)

색상: 회백색

안정성: 감광성

안전

유해 물질 데이터	361-37-5(Hazardous Substances Data)

methysergide C화학적 특성, 용도, 생산

용도

Methysergide (Methylergonovine EP Impurity G) is a serotonergic receptor antagonist.

Clinical Use

Methysergide (Sansert), which is structurally identical to methylergonovine except for the addition of a methyl group to the indole nitrogen, has far less of the uterine stimulatory properties of the other agents and, instead, is used exclusively for treatment of migraine headache as a serotonin antagonist at 5-HT1/5-HT2 receptors.Methysergide is a potent peripheral inhibitor of 5-HT receptors in the blood vessel, which inhibits vessel-wall permeability. Methysergide also inhibits the release of histamine from mast cells and stabilizes platelets against the release of 5-HT, which may be responsible for the onset of the migraine attack. In contrast to its peripheral effects, methysergide appears to be a central 5-HT1 agonist, resulting in alleviation of the central hyperalgesia effect that occurs in patients with migraine.

methysergide 준비 용품 및 원자재

원자재

칼륨 암모니아(가스) 요오드 메탄 말레인산

준비 용품

methysergide 공급 업체

글로벌( 10)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Alfa Chemistry	+1-5166625404	Info@alfa-chemistry.com	United States	21317	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49999	58
QUALITY CONTROL SOLUTIONS LTD.	0755-66853366 15920483169	sales@chem-strong.com	China	18810	58
Cdreamlab (Hubei) Technology Co., LTD	0717-6300888 18062399888	service@cdreamlab.com	China	315	58

methysergide 관련 검색:

Sumatriptan Zolmitriptan ERGONOVINE METHYSERGIDE MALEATE Propisergide methysergide N,N'-DIISOPROPYL-1,3-PROPANEDIAMINE METHYLERGONOVINE