ABT 737 manufacturers and suppliers

ABT 737 suppliers

Properties

Melting point:: 152-154°C

Density: 1.38±0.1 g/cm3(Predicted)

storage temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C

solubility: DMSO (Slightly), Methanol (Slightly, Heated, Sonicated)

form: Yellow solid

pka: 4.65±0.10(Predicted)

color: Light Yellow to Yellow

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

HS Code: 29309090

Use

ABT-737 is a small-molecule inhibitor of the anti-apoptotic proteins Bcl-2, Bcl-X(L) and Bcl-w, with potential pro-apoptotic and antineoplastic activities, with an affinity two to three orders of magnitude more potent than previously reported compounds. Mechanistic studies reveal that ABT-737 does not directly initiate the apoptotic process, but enhances the effects of death signals, displaying synergistic cytotoxicity with chemotherapeutics and radiation. ABT-737 exhibits single-agent-mechanism-based killing of cells from lymphoma and small-cell lung carcinoma lines, as well as primary patient-derived cells, and in animal models, ABT-737 improves survival, causes regression of established tumors, and produces cures in a high percentage of the mice.

You can find ABT 737 suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.