Acetohydroxamic acid manufacturers and suppliers

Acetohydroxamic acid suppliers

Properties

Melting point:: 88-90 °C (lit.)

Boiling point:: 133.7°C (rough estimate)

Density: 1.2269 (rough estimate)

refractive index: 1.4264 (estimate)

storage temp.: Keep in dark place,Inert atmosphere,Room temperature

solubility: Methanol (Sparingly), Water (Sparingly)

form: Crystalline Solid

pka: 8.70(at 25℃)

color: White to pale yellow

Water Solubility: Soluble in water.

Sensitive: Hygroscopic

Merck: 14,63

BRN: 1739019

Stability:: Moisture and Temperature Sensitive

InChIKey: RRUDCFGSUDOHDG-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H360

Precautionary statements: P201-P280-P308+P313

Hazard Codes: T

Risk Statements: 61-40

Safety Statements: 53-45-36/37/39-22

RIDADR: 3263

WGK Germany: 3

RTECS: AK8157000

Hazard Note: Toxic

PackingGroup: II

HS Code: 29225090

Toxicity: mmo-sat 160 mmol/plate JOPHDQ 3,557,80

Use

Acetohydroxamic acid is a potent, non-competitive and irreversible inhibitor of bacterial urease (Ki≈lO-7M). This enzyme, which is widely distributed in plants and bacteria, but not in mammalian cells, catalyzes the decomposition of urea to ammonia. Elevated urinary ammonia levels can reduce the antibacterial effectiveness of a number of agents. Thus, acetohydroxamic acid is useful as adjunctive therapy to decrease urinary ammonia and alkalinity in patients with chronic urea-splitting urinary infection. Such infections are a leading cause of recurring complications and death in paraplegics.

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