Alitame manufacturers and suppliers

Alitame suppliers

Properties

Melting point:: 136-147°

alpha: D25 +40 to +50° (c = 1 in water)

Boiling point:: 608.5±55.0 °C(Predicted)

Density: 1.25±0.1 g/cm3(Predicted)

solubility: Methanol (Slightly)

form: Solid

pka: 3.71±0.10(Predicted)

color: White to Off-White

Odor: odorless

Odor Type: odorless

LogP: 1.508 (est)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P301+P312+P330

HS Code: 29400090

Use

Alitame may be synthesized by a number of routes.For example, 3-(D-alaninamido)-2,2,4,4-tetramethylthietane is dissolved in water and L-aspartic acid N-thiocarboxyanhydride is then added in portions with vigorous stirring, maintaining the pH of 8.5–9.5. The pH is then adjusted to 5.5 and p-toluenesulfonic acid monohydrate is added over a period of one hour. The precipitated crystalline p-toluenesulfonate salt is collected by filtration. To obtain alitame from its salt, a mixture of Amberlite LA-1 (liquid anion exchange resin), dichloromethane, deionized water, and the salt is stirred for one hour, resulting in two clear layers. The aqueous layer is treated with carbon, clarified by filtration, and cooled to crystallize alitame. Alternatively, tetramethylthietane amine is condensed with anNprotected form of D-alanine to give alanyl amide. This is then coupled to a protected analogue of L-aspartic acid to give a crude form of alitame. The crude product is then purified.

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