Atropine sulfate manufacturers and suppliers

Atropine sulfate suppliers

Properties

Melting point:: 189-192 °C (A)(lit.)

Boiling point:: 135 °C

Density: 1.1172 (rough estimate)

refractive index: 1.6900 (estimate)

storage temp.: 0-6°C

solubility: Soluble in DMSO

color: Crystals

InChIKey: HOBWAPHTEJGALG-AADVZIIPNA-N

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H300-H330

Precautionary statements: P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501-P264-P270-P301+P310-P321-P330-P405-P501

Hazard Codes: T+

Risk Statements: 26/28

Safety Statements: 23-45

RIDADR: UN 1544 6.1/PG 2

WGK Germany: 2

F: 3-8-10

Toxicity: LD50 oral in rat: 600mg/kg

Use

Atropine sulfate (Atropisol)is prepared by neutralizing atropine in acetone or ethersolution with an alcoholic solution of sulfuric acid, withcare used to prevent hydrolysis. The salt occurs as colorlesscrystals or as a white, crystalline powder. It is efflorescentin dry air and should be protected from light to preventdecomposition.Atropine sulfate is freely soluble in water (1:0.5), in alcohol(1:5, 1:2.5 at boiling point), and in glycerin (1:2.5).Aqueous solutions are not very stable, although solutionsmay be sterilized at 120°C (15 lb pressure) in an autoclave if the pH is kept below 6. Sterilization probably is besteffected by the use of aseptic techniques and a bacteriologicalfilter. It has been suggested that no more than a 30-daysupply of an aqueous solution should be made and that forsmall quantities the best procedure is to use hypodermictablets and sterile distilled water. Kondritzer andZvirblis have studied the kinetics of alkaline and protoncatalyzedhydrolyses of atropine in aqueous solution. Theregion of maximal stability lies between pH 3 and approximately5. They have also proposed an equation to predictthe half-life of atropine undergoing hydrolysis at constantpH and temperature.

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