BMN 673 manufacturers and suppliers

BMN 673 suppliers

BMN 673

CAS:: 1207456-01-6

MF:: C19H14F2N6O

MW:: 380.35

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Properties

Melting point:: 247 - 249°C

Density: 1.63

storage temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere

solubility: DMSO (Slightly), Methanol (Slightly)

form: Solid

pka: 10.14±0.60(Predicted)

color: White to Off-White

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H360-H372-H341

Precautionary statements: P260-P264-P270-P314-P501-P201-P202-P281-P308+P313-P405-P501

Use

BMN-673 selectively binds to PARP and prevents PARP-mediated DNA repair of single strand DNA breaks via the base-excision repair pathway. This enhances the accumulation of DNA strand breaks, promotes genomic instability and eventually leads to apoptosis. BMN 673 selectively kills cancer cells with BRCA-1 or BRCA-2 mutations. BMN 673 demonstrates single-agent cytotoxicityin BRCA-1 mutant (MX-1, IC50 = 0.3 nM) and BRCA-2 mutant cells (Capan-1, IC50 = 5 nM). In contrast, in MRC-5 normal human fibroblastand other tumor cell lines with wild-type BRCA-1 and BRCA-2 genes, IC50 of BMN 673 ranges between 90 nM and 1.9 μM. In cultured human cancer cells, BMN 673 also significantly enhances the cytotoxic efficacy of both Temozolomide and SN-38. Off-target molecular screening did not identify significant non-specific activity for this class of PARP inhibitors.

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