Bupivacaine manufacturers and suppliers

Bupivacaine suppliers

Properties

Melting point:: 107.5-108°

Boiling point:: 430.65°C (rough estimate)

Density: 1.0238 (rough estimate)

refractive index: 1.5700 (estimate)

pka: 8.09; also reported as 8.17(at 25℃)

Water Solubility: 101.5mg/L(25 ºC)

InChI: InChI=1S/C18H28N2O/c1-4-5-12-20-13-7-6-11-16(20)18(21)19-17-14(2)9-8-10-15(17)3/h8-10,16H,4-7,11-13H2,1-3H3,(H,19,21)

InChIKey: LEBVLXFERQHONN-UHFFFAOYSA-N

SMILES: C1(CCCCN1CCCC)C(=O)NC1C(C)=CC=CC=1C

Safety Information

Symbol(GHS): GHS07,GHS05,GHS06

Signal word: Danger

Hazard statements: H315-H310-H318-H330-H300

Precautionary statements: P262-P264-P270-P280-P302+P350-P310-P322-P361-P363-P405-P501-P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310-P264-P270-P301+P310-P321-P330-P405-P501-P260-P271-P284-P304+P340-P310-P320-P403+P233-P405-P501

Hazard Codes: T+

Risk Statements: 26/27/28-38-41

Safety Statements: 22-26-36/37/39-45

RIDADR: 2811

Use

Bupivacaine was synthesized simultaneously with mepivacainein 1957 but was at first overlooked because of the increasedtoxicity compared with mepivacaine. When themethyl on the cyclic amine of mepivacaine is exchanged fora butyl group the lipophilicity, potency and the duration ofaction all increase. Literature reports of cardiovascular toxicity,including severe hypotension and bradycardia, areabundant in the literature.91 Bupivacaine is highly bound toplasma proteins (95%), and thus the free concentration mayremain low until all of the protein binding sites are occupied.After that point, the plasma levels of bupivacaine rise rapidlyand patients may progress to overt cardiac toxicity withoutever showing signs of CNS toxicity. The cardiotoxicity ofbupivacaine is a result of its affinity to cardiac tissues and itsability to depress electrical conduction and predispose theheart to reentry types of arrhythmias. The cardiotoxicity ofbupivacaine was found to be significantly more prominentwith the “R” isomer, or the racemic mixture, thus the “S”stereoisomer is now on the market as levobupivacaine.

You can find Bupivacaine suppliers, manufacturers, and distributors from countries such as CHINA, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.