Cabozantinib manufacturers and suppliers

Cabozantinib suppliers

Cabozantinib

CAS:: 849217-68-1

MF:: C28H24FN3O5

MW:: 501.51

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Properties

Melting point:: 212-215°C

Boiling point:: 758.1±60.0 °C(Predicted)

Density: 1.396

storage temp.: -20°C

solubility: Soluble in DMSO

form: White powder.

pka: 13.86±0.70(Predicted)

color: White

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.

Safety Information

Symbol(GHS): GHS05

Signal word: Danger

Hazard statements: H315-H318

Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P280-P305+P351+P338-P310

Use

In clinical trials, common adverse effects caused by cabozantinib include diarrhea, stomatitis, palmar-plantarrythrodysesthesia syndrome (PPES), and loss of weight, loss of appetite, nausea, fatigue, oral pain, taste disorders, high blood pressure, abdominal pain and constipation. The most common laboratory abnormalities ( 25%) were increased aspartate aminotransferase, alanine aminotransferase, lymphopenia, increased alkaline phosphatase level, hypocalcemia, neutropenia, thrombocytopenia, hypophosphatemia and hyperbilirubinemia. For patients receiving cabozantinib, 57% of patients have gotten increased level of thyroid stimulating hormone after initial dose, compared with patients receiving placebo, increased by 19%. Information regarding to the anticancer drug, mechanism of action, pharmacokinetics, side effects, and drug interactions of cabozantinib were compiled and edited by Yan Shi from Chemicalbook. (2015-10-23)

You can find Cabozantinib suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.