Clioquinol manufacturers and suppliers

Clioquinol suppliers

Properties

Melting point:: 175-183 °C

Boiling point:: 350.4±37.0 °C(Predicted)

Density: 1.8959 (estimate)

vapor pressure: 0Pa at 25℃

storage temp.: 2-8°C

solubility: Soluble in DMSO (>25 mg/ml), boiling alcohol ((1:43)), methanol, and chloroform ((1:120)).

pka: pKa 8.12(50%aqEtOH t=35.0±0.1 I=0.00 N2atmosphere)(Approximate)

form: Solid

color: Light Beige to Beige

Water Solubility: <0.1 g/100 mL at 20 ºC

Merck: 14,5031

BRN: 153637

LogP: 1.523 at 24℃

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301-H315-H317-H319

Precautionary statements: P261-P264-P280-P301+P310-P302+P352-P305+P351+P338

Hazard Codes: T

Risk Statements: 25

Safety Statements: 36/37/39-45

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: VC5075000

TSCA: Yes

HazardClass: 6.1(b)

PackingGroup: III

HS Code: 2933492250

Toxicity: LD50 orally in cats: 400 mg/kg (Davis)

Use

Clioquinol, a halogenated hydroxyquinoline derivative, was introduced into medicine around 1900 as a topical antiseptic and in 1934 oral preparations for the treatment of amoebic dysentery and simple diarrhoea became available. By 1964 its use in Japan had been associated with cases of sub-acute myelo-optic neuropathy (SMON) which reached epidemic proportions resulting in its withdrawal there in 1970. Although relatively few cases of SMON were documented elsewhere, clioquinol was subsequently withdrawn from use in many countries and placed under prescription control in others. It was phased out worldwide by the major manufacturer between 1983 and 1985 on grounds of obsolescence. No adequately controlled evidence was ever generated to demonstrate that clioquinol is effective in bacterial or viral diarrhoea. However, products containing clioquinol and related halogenated hydroxyquinolines continue to be used in some tropical and subtropical countries where amoebiasis remains endemic. Other amoebocides are preferred in the WHO Model List of Essential Drugs. (Reference: (WHODI) WHO Drug Information, 77.1, 9, 1977)

You can find Clioquinol suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.