Dimethyl fumarate manufacturers and suppliers

Dimethyl fumarate suppliers

Properties

Melting point:: 102-106 °C (lit.)

Boiling point:: 192-193 °C (lit.)

Density: 1,37 g/cm³

vapor pressure: 5 hPa (25 °C)

refractive index: 1.4062 (estimate)

Flash point:: 192-193°C

storage temp.: Store below +30°C.

solubility: 1.6g/l

form: Liquid

color: Clear colorless to faintly yellow

PH: 4.0-6.0 (10g/l, H2O, 20℃)suspension

Water Solubility: Soluble in water (1.6 mg/ml at 20°C), methanol (30-36 mg/ml), ethanol (10 mg/ml at 25°C), DMSO (29 mg/ml at 25°C), and DMF (~12 mg/ml).

Merck: 14,4287

BRN: 774590

Stability:: Stable. Incompatible with acids, bases, oxidizing agents, reducing agents.

Safety Information

Symbol(GHS): GHS07,GHS09

Signal word: Warning

Hazard statements: H312-H315-H317-H335-H411

Precautionary statements: P261-P264-P271-P273-P280-P302+P352+P312

Hazard Codes: Xn

Risk Statements: 21-38-41-43-36/37/38-36/38

Safety Statements: 26-36/37/39-36/37

RIDADR: UN 3077 9 / PGIII

WGK Germany: 1

RTECS: EM6125000

TSCA: Yes

HS Code: 29171990

Toxicity: LD50 orally in Rabbit: 2240 mg/kg LD50 dermal Rabbit 1250 mg/kg

Use

Dimethyl fumarate is the methyl ester of fumaric acid. Dimethyl fumarate, marketed in Germany under the trade name of Fumaderm, is used for oral therapy of psoriasis in combination with other drugs. Later it has been used to treat adults with relapsing multiple sclerosis[a chronic inflammatory, demyelinating and neurodegenerative disease of the CNS resulting in neurological disability] since 2013(trade name Tecfidera). Dimethyl fumarate is thought to have immunomodulatory properties without significant immunosuppression. In preclinical studies, dimethyl fumarate exhibited anti-inflammatory and cytoprotective properties that are generally thought to be mediated via activation of the nuclear factor [erythroid-derived 2]-like 2 transcriptional pathway, which is involved in the cellular response to oxidative stress.

You can find Dimethyl fumarate suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.