Diphenoxylate suppliers
Diphenoxylate
- CAS:
- 915-30-0
- MF:
- C30H32N2O2
- MW:
- 452.59
Properties
- Boiling point:
- 602.3±55.0 °C(Predicted)
- Density
- 1.123±0.06 g/cm3(Predicted)
- pka
- pKa 7.1 (Uncertain)
Safety Information
- Hazard Codes
- T+
- Risk Statements
- 26/27/28-42/43
- Safety Statements
- 22-26-45
- Toxicity
- Diphenoxylate is an antiperistaltic, antidiarrheal drug that is also listed as a controlled substance (opiate).
Use
Diphenoxylate is a weak opioid agonist and isavailable combined with atropine (Lomotil) for use as an antidiarrhealagent. At low doses, the opioid effect is minimal,and the atropine is added to dissuade abuse. One studyfound both codeine and loperamide to be superior to diphenoxylatefor treating chronic diarrhea.83 The manufacturerhas strict dosing guidelines for pediatric use because opioidintoxication and deaths from diphenoxylate have beenreported.
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