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Dolasetron mesylate

CAS:
115956-13-3
MF:
C20H26N2O7S
MW:
438.49

Properties

Melting point:
278°
storage temp. 
2-8°C
solubility 
H2O: >30mg/mL
form 
powder
color 
white to off-white

Safety Information

WGK Germany 
3

Use

Vomiting is an extremely complex reflex activity, involving a variety of neurotransmitters. Antiemetics produce antiemetic effect by blocking different receptors. 5-HT3 receptor blocking drugs can selectively block the 5-HT3 receptors of the central and vagal afferent fibers , resulting in strong antiemetic effect. For vomiting caused by anticancer drugs, its antiemetic effect is quick and powerful, but it is invalid in vomiting caused by motion sickness and apomorphine.It is clinically used for chemotherapy, radiotherapy-induced nausea and vomiting. Clinical application includes ondansetron (Zofran), granisetron , dolasetron mesylate, dolasetron and tropisetron , its clinically equivalent doses are 8mg, 3mg, 100mg and 5mg. Dolasetron mesylate is an anti-emetic drug, it is originally developed by the German company Hoechst Marion Roussel , it is developed as a selective serotonin (5-HT3) receptor antagonist, its acting is similar to Ondansetron and granisetron. The oral administration and intravenous injections of the product are effective for preventing and treating nausea and vomiting caused by cancer chemotherapy. 5-HT3 receptor antagonist in combination with dexamethasone or other corticosteroids is the most effective combined therapy for the prevention of acute vomiting caused by cancer chemotherapy . US FDA suggests that the product can also be used for the prevention and treatment of postoperative nausea or vomiting. Dolasetron mesylate is rapidly metabolized to hydrogenated dolasetron in plasma and liver , the active metabolite in the liver is further metabolized by the CYP2D6 and CYP3A , then it is excreted with urine and feces, the half-life of the product is about 8h.

77 supplier list of "Dolasetron mesylate"

  • Product Name:Dolasetron mesylate
  • Products Intro:Purity: 0.99 | Package: 25KG,5KG;1KG;500G
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0371-55170693
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: 86-21-51086038
  • Products Intro:Purity: 0.99 | Package: 25KG;5KG;1KG;500G
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0371-55170695
  • Product Name:dolasetron mesylate
  • Products Intro:Purity: 0.99 | Package: 1kg
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 86-18523575427

    US $1.00/ 1KG

  • Product Name:Dolasetron (Mesylate)
  • Products Intro:Purity: Min98% HPLC | Package: 1KG;1USD
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0086-371-86658258
  • Product Name:Dolasetron mesylate hydrate
  • Products Intro:Purity: 0.99 | Package: 1KG;5KG;10KG;25KG;50KG
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +8613111626072
  • Main Products: Food Additives,Chemical pesticides
  • Product Name:Dolasetron mesylate
  • Products Intro:Purity: 0.97 | Package: mgs,gs,kgs | CustNote: A854565
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: 0086-571-89925085
  • 10mg$72.10
    50mg$292.00
  • Product Name:Dolasetron mesylate hydrate
  • Products Intro:Brand: Sigma-Aldrich | Product Number: D9571 | Purity: ≥98% (HPLC), powder
  • Type of Enterprise: Trader
  • Country/Region: UNITED STATES
  • TEL: 800 558-9160
  • Product Name:Dolasetron Mesylate
  • Products Intro:Purity: 98% | Package: 1KG;5KG;20KG;50KG
  • Type of Enterprise: Manufacturer
  • Country/Region: CHINA
  • TEL: 028-82783659;028-82666753
  • 10 mg$69.00
    50 mg$289.00
  • Product Name:3-Oxooctahydro-2,6-methano-2H-quinolizin-8-yl 1H-indole-3-carboxylate methanesulfonate
  • Products Intro:Brand: Tocris Bioscience | Product Number: 5629 | Purity: ≥99% (HPLC)
  • Type of Enterprise: Trader
  • Country/Region: UNITED KINGDOM
  • TEL: +44 (0) 117 916 3333

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