Ebastine manufacturers and suppliers

Ebastine suppliers

Properties

Melting point:: 80-82°C

Boiling point:: 596.3±50.0 °C(Predicted)

Density: 1.09±0.1 g/cm3(Predicted)

storage temp.: 2-8°C

solubility: Slightly soluble in chloroform, methanol.

form: solid

pka: 8.19±0.10(Predicted)

color: white

Merck: 14,3484

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H303

Precautionary statements: P270-P301+P312-P403-P501c

WGK Germany: 3

RTECS: EL8140000

HS Code: 2933.39.9200

Use

Ebastine belongs to an effective second generation histamine H1 receptor antagonist. One important property of it is that it doesnt penetrate the blood brain barrier. Therefore, it is capable of blocking the H1 receptor in peripheral tissue without having some specific side effects such as sedation and drowsiness. Ebastine is mainly applied for the treatment of allergic rhinitis, pruritus as well as acting as an alternative drug in Decongestant. Upon entering into the human body, it can subject to the action of hepatic cytochrome P450 3A4 to be converted to an active carboxylic acid metabolite, carebastine. The later one is the major active form in vivo. Under certain range, it can inhibit T cell proliferation and the production of Th2-type pro-inflammatory cytokines through macrophages. Ebastine generally has a high safety property without causing cognitive/psychomotor impairment and sedation, like placebo. However, it can cause side effects such as inflammation of the air-cavities around nose, sore throat, indigestion, nausea, headache, and abdominal pain.

You can find Ebastine suppliers, manufacturers, and distributors from countries such as China, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.