Request for quotation
My ChemicalBook
My ChemicalBook
Welcome to chemicalbook!
400-158-6606
Try our best to find the right business for you.
Do not miss inquiry messages Please log in to view all inquiry messages.

Welcome back!

Ergosterol

CAS:
57-87-4
MF:
C28H44O
MW:
396.66

Properties

Melting point:
156-158 °C(lit.)
Boiling point:
250 °C (1.3 mmHg)
alpha 
-120 º (c=1, CHC13)
Density 
0.9784 (rough estimate)
refractive index 
-112.5 ° (C=1, THF)
storage temp. 
-20°C
pka
14.91±0.70(Predicted)
form 
Crystalline Powder or Crystalline Needles
color 
White to off-white
optical activity
[α]20/D 120±10°, c = 1% in chloroform
Water Solubility 
PRACTICALLY INSOLUBLE
Sensitive 
Light Sensitive
Merck 
14,3659
BRN 
2338604
Stability:
Stable, but may be light or air sensitive. Incompatible with acids, strong oxidizing agents.
InChIKey
DNVPQKQSNYMLRS-APGDWVJJSA-N

Safety Information

Symbol(GHS) 

GHS06,GHS08
Signal word 
Danger
Hazard statements 
H300-H413-H302-H315-H319-H331-H336-H351-H361d-H372
Precautionary statements 
P264-P270-P301+P310a-P321-P405-P501a-P261-P281-P305+P351+P338-P311
Hazard Codes 
T+,T,Xn
Risk Statements 
28-48/20/22-40-38-25-67-36/38-22-20-63
Safety Statements 
28-36/37-45-26
RIDADR 
UN 2811 6.1/PG 2
WGK Germany 
3
1-3-8-10
HazardClass 
6.1
PackingGroup 
II
HS Code 
29334900

Use

Since ergosterol is a key component in cell membranes of fungi, yet absent in those of animals. It has become a very useful target for antifungal drugs. Ergosterol is also present in the cell membranes of some protists, such as trypanosomes. This also becomes the basis for the use of some antifungals against West African sleeping sickness. Antifungal drugs targeting ergosterol includes Amphotericin B[2, 3], fluconazole, miconazole, itraconazole, and clotrimazole. Amphotericin B acts by binding to sterols (ergosterol) in the cell membrane of susceptible fungi[2, 3]. This creates a transmembrane channel, and the resultant change in membrane permeability allowing leakage of intracellular components. Ergosterol, the principal sterol in the fungal cytoplasmic membrane, is the target site of action of amphotericin B and the azoles. Amphotericin B, a polyene, binds irreversibly to ergosterol, resulting in disruption of membrane integrity and ultimately cell death[2, 3]. Amphotericin B, though has been replaced by safer agents in most circumstances, is still used, despite its side effects, for life-threatening fungal or protozoan infections. Fluconazole, miconazole, itraconazole, and clotrimazole work in a different way, take effect through inhibiting synthesis of ergosterol from lanosterol by interfering with14-demethylase[4, 5]. Fluconazole interacts with 14- demethylase, a cytochrome P-450 enzyme necessary to convert lanosterol to ergosterol. As ergosterol is an essential component of the fungal cell membrane, inhibition of its synthesis results in increased cellular permeability causing leakage of cellular contents. Fluconazole may also inhibit endogenous respiration, interact with membrane phospholipids, inhibit the transformation of yeasts to mycelial forms, inhibit purine uptake, and impair triglyceride and/or phospholipid biosynthesis.

295 supplier list of "Ergosterol"

  • Product Name:Ergosterol
  • Products Intro:Purity: 99% | Package: 500G;1KG;5KG;25KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Ganoderma lucidum Polysaccharide
  • Products Intro:Purity: as in COA | Package: as customers' requirements
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Ergosterol
  • Products Intro:Purity: 98% HPLC | Package: 5G;10G;25G;50G;100G;250G;1KG
  • Company Type: Reagent
  • Country/Region: CHINA
  • Product Name:Ergosterol
  • Products Intro:Purity: HPLC>=98% | Package: 20mg/100mg
  • Company Type: Trader
  • Country/Region: CHINA

    $1.00/ 1KG

  • Product Name:Ergosterol
  • Products Intro:Purity: 99% | Package: 1KG;1USD
  • Company Type: Reagent
  • Country/Region: CHINA
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Product Name:Ergosterol
  • Products Intro:Purity: 90%~98% HPLC | Package: 20mg;100mg;500mg;1g | CustNote: BP0549
  • Company Type: Reagent
  • Country/Region: CHINA
  • Product Name:Ergosterol
  • Products Intro:Purity: 99% | Package: 5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Apis
  • Product Name:Ergosterol
  • Products Intro:Package: 1kg,2kg,5kg,10kg,25kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Ergosterol
  • Products Intro:Purity: 0.99 | Package: 1g;25g;1kg;25kg;100kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: APIs,NADH
  • Product Name:Ergosterol
  • Products Intro:Purity: 0.99 | Package: 5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA

Ergosterol Related Search:

LYSERGOLIsoquercitrinFERULIC ACID METHYL ESTERCeftiofur hydrochlorideErgosterolDiosgeninBetulinTerbinafine hydrochlorideVitamin D2ergotamine CholesterolTriethylenetetramineSTIGMASTEROL
HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links| Pricacy| Terms| Product Manufacturers| New Products
Copyright © 2019 ChemicalBook All rights reserved.