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Gliquidone

CAS:
33342-05-1
MF:
C27H33N3O6S
MW:
527.63

Properties

Melting point:
179 °C
Density 
1.34±0.1 g/cm3(Predicted)
storage temp. 
Inert atmosphere,Room Temperature
pka
5.12±0.10(Predicted)
Merck 
14,4443

Safety Information

Safety Statements 
24/25
RTECS 
DB1584250
HS Code 
29147000

Use

Gliquidone is an oral hypoglycemic agent, and was called as the second generation sulfonylurea oral hypoglycemic drug together with glyburide, gliclazide and glipizide, primarily for the treatment of non-insulin-dependent (namely, II type) diabetes. Its mechanism of action is the same as other sulfonylurea drugs and can stimulate insulin secretion from pancreatic β cells, and can enhance the action of insulin, enhance the sensitivity of tissues to insulin action, increase the number of insulin receptor and strengthen post-receptor action of insulin. During the early phase of treatment, it is mainly used for promoting the secretion of endogenous insulin; after a period of time of treatment, its main role is to improve the sensitivity of peripheral tissues to insulin. Diabetic nephropathy is one of the late complications of diabetes while gliquidone is the only sulfonylurea drugs that not affected by renal function and therefore can be applied to diabetic patients with impaired renal function. It is the primary-choice of drug for the treatment of patients of non-insulin dependent diabetes accompanied with insufficiency of renal function. Gliquidone is characterized by short duration of action and seldom undergoing of renal excretion with a small dose being able to control postprandial blood glucose. Oral absorption is quick and complete. After the first oral administration of 30mg, the plasma concentration reaches its peak value, 500~700μg/L after 2 to 3 hours. The efficacy onset occurs at 1 hour after administration, the maximal effect can be extended up to 2 to 3 hours with the duration of 8 hours and the plasma protein binding rate being 99% and the half-life of about 1.5 hours. It is mainly metabolized in the liver through hydroxylation or demethylation with its metabolites having no significant hypoglycemic activity and most of them being discharged through feces via biliary while only 5% being subject to renal excretion. This product has mild effect and can be subject to dose adjustment timely based on blood sugar or urine glucose and rarely cause hypoglycemia reaction. It is suitable for the treatment of adult-type mild, moderate diabetes which can’t be simply treated through diet, especially for patients with renal insufficiency.

168 supplier list of "Gliquidone"

  • Product Name:Gliquidone
  • Products Intro:Purity: 98% | Package: 100G;1KG;5KG;10KG;25KG;50KG;100KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Gliquidone
  • Products Intro:Purity: 99% | Package: 500G;1KG;5KG;25KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Gliquidone;AR-DF 26;Glurenorm;Glurenorm
  • Company Type: Trader
  • Country/Region: CHINA

    $10.00/ 1KG

  • Product Name:Gliquidone 33342-05-1
  • Products Intro:Purity: 99% | Package: 1KG;10USD
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Gliquidone
  • Products Intro:Purity: 98% | Package: 500g;1kg;5kg;10kg;100kg;1000kg... | CustNote: pharmaceutical intermediates
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Gliquidone
  • Products Intro:Purity: HPLC>=98% | Package: 20mg
  • Company Type: Trader
  • Country/Region: CHINA

    $1.00/ 1KG

  • Product Name:Gliquidone
  • Products Intro:Purity: 98% | Package: 1KG;1USD
  • Company Type: Reagent
  • Country/Region: CHINA
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Product Name:Gliquidone
  • Company Type: Service provider
  • Country/Region: CHINA
  • Main Products: UDDA
  • Product Name:Gliquidone
  • Products Intro:Purity: 0.99 | Package: 500g 1kg 25kg 111kilograms per barrel
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Gliquidone
  • Products Intro:Purity: 0.99 | Package: 5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA

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