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Imiquimod

CAS:
99011-02-6
MF:
C14H16N4
MW:
240.3

Use

Imiquimod itself has no direct effect on the virus itself, but instead through stimulating the body for producing cytokines and stimulating immune response to eliminate the wart tissue and reduce the viral erosion. Both in vivo and in vitro studies have suggested that imiquimod can stimulate the mice, rats, rabbits, guinea pigs, monkeys and humans for producing cytokine. Racial cross cell culture tests have shown that the main responsive cells are monocytes/macrophages; cultured human peripheral mononuclear cells (PBMC) which can produce several subtypes of IFN-α, TNF-α, IL-1,6,6 , 10,12, MIP-1 and MCP-1; the human single cell THP-1 will respond only when being pre-subject to γ-IFN treatment and produce TNF-α, IL-1,6,8, but do not produce IFN-α; performing the same treatment on the fresh mice PBMC can generate the same cytokine as human PBMC; senescence macrophages and alveolar macrophages produce the same cytokines, the mouse RAW264.7 and J774 macrophages family can produce TNF-α and IL-6 without producing IFN-α. Through intracellular test, we can confirm that imiquimod can induce IFN-α and TNF-α. Through putting the human fibroblasts and keratinocytes with the mixture of imiquimod or poly-inosine: poly-cytidine for incubation of 24 hours, people has found that the mRNA of keratinocytes IL-6 and IL-8 (no TNF-α) had increased but only appropriate amount of IL-8 protein had been detected. At high concentration, the secretion of the fibroblasts IL-8 is similar with keratinocytes; The immune response of caused by the imiquimod-induced secretion of cytokines is similar with the DTH response; imiquimod can activate the anti-tumor activity and DTH response of the HPV E7 gene transfected tumor bearing mice; human and animal experiments have shown that imiquimod could increase the 2'5'-oligo-adenylate synthase which can induce the interferon for inducing the antiviral effect; interferons and other cytokines can activate NK cells to kill tumor cells and the virus-infected cells; both in vivo and in vitro tests have showed that the imiquimod can increase activity of NK and stimulate the proliferation and activation of mouse spleen B cells which is the direct effect rather than being mediated by cytokine; imiquimod does not directly enhance T-lymphocyte activity; but in vitro mitogenic response can stimulate T-cells for enhancing the production and proliferation of IL-2. In vivo experiments have demonstrated that it can enhance T cell activity; imiquimod can increase the generation of IL-2 of the HSV infected guinea pig, T cell proliferation and T cell activity to enhance the cell-mediated immune response. The above information is edited by the Chemicalbook of Dai Xiongfeng.

173 supplier list of "Imiquimod"

  • Product Name:Imiquimod
  • Products Intro:Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86 (0)571-855 867 18
  • Product Name:Imiquimod
  • Products Intro:Purity: 99% | Package: 9020/KG
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: 0755-23311925 18102838259
  • Product Name:Imiquimod
  • Products Intro:Purity: 99.00% | Package: 100g,500g,1KG,10KG,100KG
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-371-55531817
  • Main Products: Speciality Chemicals
  • Products Intro:Purity: 99% | Package: 500G;1KG;5KG;25KG
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0371-55170693
  • Product Name:Imiquimod
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-021-57951555
  • Product Name:Imiquimod
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-0592-6210733
  • Product Name:imiquimod
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86 21 5161 9050/ 5187 7795

    US $2.00/ 1kg

  • Product Name:Imiquimod
  • Products Intro:Purity: 99% | Package: 1kg;2USD
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-371-86658258
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Products Intro:Purity: 99% | Package: 5KG;1KG;25KG PRICE quotation | CustNote: Factory stock, quality assurance, price concessions
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: 86-21-51086038
  • Product Name:imiquimod
  • Products Intro:Purity: 99% | Package: 5KG;1KG | CustNote: C14H16N4
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 86-18871470254
  • Main Products: Apis

Imiquimod Related Search:

1-(2-METHYLPROPYL)-1H-IMIDAZO[4,5-C]QUINOLINE4-Chloro-1-(2-methylpropyl)-1H-imidazo[4,5-c]quinoline5-AZABENZIMIDAZOLERESIQUIMODImiquimodQuincloracAnilineAMINO ACIDSBis(2-ethylhexyl)amineGlycineEthoxyquin1,2,3,4-TETRAHYDROISOQUINOLINEQuinhydroneALTRENOGESTBetaineIsoquinolineLithium diisopropylamide
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