L-Thyroxine manufacturers and suppliers

L-Thyroxine suppliers

Properties

Melting point:: 235 °C

alpha: -5 º (1N NaOH:EtOH 1:2)

Density: 2.4440 (estimate)

Flash point:: 9℃

storage temp.: Keep in dark place,Inert atmosphere,2-8°C

solubility: Dissolves in 4M ammonium hydroxide in Methanol at 50mg/ml

pka: 2.2(at 25℃)

Boiling point:: 576.3±50.0 °C(Predicted)

form: Powder

color: White to Pale Brown

Water Solubility: insoluble

Sensitive: Light Sensitive

Merck: 9491

BRN: 2228515

InChIKey: XUIIKFGFIJCVMT-LBPRGKRZSA-N

Safety Information

Symbol(GHS): GHS02,GHS06,GHS08

Signal word: Danger

Hazard statements: H225-H301+H311+H331-H370

Precautionary statements: P210-P260-P280-P301+P310+P330-P302+P352+P312-P370+P378

Hazard Codes: Xn,T,F

Risk Statements: 40-39/23/24/25-23/24/25-11

Safety Statements: 22-24/25-36-45-36/37-16

RIDADR: UN1230 - class 3 - PG 2 - Methanol, solution

WGK Germany: 3

RTECS: YP2833500

F: 8-10

TSCA: Yes

HazardClass: IRRITANT

HS Code: 29379000

Toxicity: TDLo oral in child: 328ug/kg

Use

L-thyroxine is the major hormone derived from the thyroid gland. It is synthesized via the iodination of tyrosines (monoiodotyrosine) and the coupling of iodotyrosines(diiodotyrosine)in the thyroglobulin. Thyroxine is released from thyroglobulin by proteolysis and secreted into the blood. Thyroxine is peripherally deiodinated to form triiodothyronine that exerts a broad spectrum of stimulatory effects on cell metabolism. It is mainly used for the treatment of hypothyroidism, goiter, chronic lymphocytic thyroiditis, myxedema coma, and stupor[1]. The thyroid gland is responsible for the synthesis, storage and release of metabolic hormones including iodine-containing thyroxine(T4) and triiodothyroxine(T3). These hormones are crucial in the regulation of many metabolic processes and are vital for normal growth and development. They are also involved in calorigenic, cardiovascular and metabolic effects. The hormones exert their effects presumably by activating gene transcription of messenger RNA and proteins. To do so, they enter the cell nucleus and bind to DNA-bound thyroid receptors, which regulate gene transcription[2, 3].

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