Nizatidine manufacturers and suppliers

Nizatidine suppliers

Properties

Melting point:: 130-1320C

Boiling point:: 478.2±45.0 °C(Predicted)

Density: 1.249±0.06 g/cm3(Predicted)

storage temp.: Keep in dark place,Inert atmosphere,Room temperature

solubility: Sparingly soluble in water, soluble in methanol.

pka: 2.1, 6.8(at 25℃)

color: Off-White to Pale Yellow

Water Solubility: 21.4g/L(temperature not stated)

Merck: 14,6660

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302

Precautionary statements: P264-P270-P301+P312-P501

Hazard Codes: Xn

Risk Statements: 22

Safety Statements: 36

WGK Germany: 3

RTECS: KM6565000

HS Code: 29349990

Toxicity: LD50 in mice, rats (mg/kg): 265, >300 i.v.; 1685, 1680 orally (Pioch)

Use

Nizatidine, N-[2-[[[2-(dimethylamino)methyl]-4-thiazolyl]methyl]thio]-ethyl]-N'-methyl-2-nitro-1,1-ethenediamine (Axid), is an off-white to buff crystallinesolid that is soluble in water, alcohol, and chloroform. It isa thaizole derivative of raniditine and has pKas of 2.1 (side chain) and 6.8 (dimethylamino). Nizatidine’s mechanism ofaction is similar to other H2-antagonists, as is its receptor selectivity.It is more potent than cimetidine.Nizatidine has excellent oral bioavailability (＞90%).The effects of antacids or food on its bioavailability arenot clinically significant. The elimination half-life is 1 to2 hours. It is excreted primarily in the urine (90%) andmostly as unchanged drug (60%). Metabolites include nizatidinesulfoxide (6%), N-desmethylnizatidine (7%), andnizatidine N-oxide (dimethylaminomethyl function).Nizatidine has no demonstrable antiandrogenic action, effectson other hormones, or inhibitory effects on cytochromeisozymes involved in the metabolism of other drugs.

You can find Nizatidine suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.