OKADAIC ACID manufacturers and suppliers

OKADAIC ACID suppliers

Properties

Melting point:: 164-166 °C

alpha: D20 +21° (c = 0.33 in CHCl3); D25 +25.4° (c = 0.24 in CHCl3)

Boiling point:: 672.95°C (rough estimate)

Density: 1.0795 (rough estimate)

refractive index: 1.5940 (estimate)

storage temp.: -20°C

solubility: DMSO: ≥1 mg/mL

form: translucent film

pka: 3.87±0.16(Predicted)

color: translucent

Water Solubility: It is soluble in ethanol (25 mg/ml), DMSO (25 mg/ml), methanol (<1 mg/ml), chloroform, acetone, ethyl acetate, DMF, and dimethylsulfoxide. Insoluble in water, unless first dissolved in organic solvents, such as DMSO or ethanol.

Merck: 13,6891

Stability:: Stable. Light and heat-sensitive. Combustible. Incompatible with strong oxidizing agents.

Safety Information

Symbol(GHS): GHS06

Signal word: Danger

Hazard statements: H301+H311+H331-H315

Precautionary statements: P280-P301+P310+P330-P302+P352+P312-P304+P340+P311

Hazard Codes: T

Risk Statements: 23/24/25-38

Safety Statements: 26-36/37-45

RIDADR: UN 3462 6.1/PG 1

WGK Germany: 3

RTECS: AA8227800

F: 10

HazardClass: 6.1(a)

PackingGroup: II

HS Code: 29321900

Toxicity: LD50 i.p. in mice: 192 mg/kg (Shibata)

Use

Okadaic acid is a widely distributed marine toxin produced by several phytoplanktonic species and responsible for diarrheic shellfish poisoning in humans. At the molecular level, Okadaic acid is a pot ent and specific inhibitor of various types of serine/threonine protein phosphatases. Due to this enzymatic inhibition, Okadaic acid was reported to induce numerous alterations in relevant cellular ph ysiological processes, including metabolic pathways such as glucose uptake, lipolysis and glycolysis, heme metabolism and glycogen and protein synthesis.

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