PENTAGASTRIN manufacturers and suppliers

PENTAGASTRIN suppliers

Properties

Melting point:: 229-230° (dec)

alpha: D22 -28.8 ±0.5° (DMF)

Boiling point:: 1196.6±65.0 °C(Predicted)

Density: 1.303±0.06 g/cm3(Predicted)

storage temp.: -20°C

solubility: Practically insoluble in water; soluble in 5M ammonia and in dimethylformamide; slightly soluble in ethanol (96%).

form: powder

pka: 4.19±0.10(Predicted)

Sequence: N-t-Boc-β-Ala-Trp-Met-Asp-Phe-NH2

InChIKey: NEYNJQRKHLUJRU-DZUOILHNSA-N

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H302+H312+H332

Hazard Codes: T

Risk Statements: 61-36/38-20/21

Safety Statements: 53-45-36/37/39-22

WGK Germany: 1

RTECS: AY2970000

Use

Pentagastrin (Peptavlon), a physiologicalgastric acid secretagogue, is the synthetic pentapeptide derivative:N-t-butyloxycarbonyl-β-alanyl-L-tryptophyl-L-methionyl-L-aspartyl-L-phenylalanyl amide. It contains theCOOH-terminal tetrapeptide amide (H·Try·Met· Asp·Phe·NH2), which is considered to be the active center ofthe natural gastrins. Accordingly, pentagastrin appears tohave the physiological and pharmacological properties ofthe gastrins, including stimulation of gastric secretion,pepsin secretion, gastric motility, pancreatic secretion ofwater and bicarbonate, pancreatic enzyme secretion, biliaryflow and bicarbonate output, intrinsic factor secretion, andcontraction of the gallbladder.Pentagastrin is indicated as a diagnostic agent to evaluategastric acid secretory function, and it is useful in testing foranacidity in patients with suspected pernicious anemia, atrophicgastritis or gastric carcinoma, hypersecretion in suspectedduodenal ulcer or postoperative stomal ulcers, andZollinger-Ellison tumor.

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