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ChemicalBook >> CAS DataBase List >>PHORBOL 12-MYRISTATE 13-ACETATE

PHORBOL 12-MYRISTATE 13-ACETATE suppliers

PHORBOL 12-MYRISTATE 13-ACETATE

CAS:
16561-29-8
MF:
C36H56O8
MW:
616.83

Properties

Melting point:
65-79oC
Boiling point:
571.87°C (rough estimate)
Density 
1.17±0.1 g/cm3 (20 ºC 760 Torr)
refractive index 
1.4900 (estimate)
storage temp. 
-20°C
solubility 
DMSO: DMSO solutions can be stored dark at −20°C for at least six months.soluble
pka
11.19±0.70(Predicted)
form 
Fine Crystalline Powder
color 
Off-white to light yellow
Water Solubility 
Very soluble in methanol, soluble in DMSO, chloroform, ethanol or acetone, ether, ethyl acetate, DMF or acetonitrile. Insoluble in water.
Sensitive 
Light Sensitive
BRN 
2407201
Stability:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
InChIKey
PHEDXBVPIONUQT-RGYGYFBISA-N

Safety Information

Symbol(GHS) 
GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS05,GHS06,GHS08
Signal word 
Danger
Hazard statements 
H300+H310+H330-H314-H317-H334-H351
Precautionary statements 
P202-P260-P280-P303+P361+P353-P304+P340+P310-P305+P351+P338
Hazard Codes 
Xi
Risk Statements 
38-36/37/38
Safety Statements 
36/37-26
RIDADR 
2928
WGK Germany 
3
RTECS 
QH4377000
8-10
HazardClass 
6.1(a)
PackingGroup 
II
HS Code 
29153900
Toxicity
Diesters of phorbol, particularly 12-O-tetradecanoylphorbol 13-acetate, also known as phorbol myristate acetate, have been identified as the potent, highly lipophilic tumor-promoting components in croton oil. They are potent promoters of skin tumors in vivo and have been shown to transform cultured fibroblasts and embryonic cells previously exposed to polycyclic aromatic hydrocarbon carcinogens in vitro. The structure of phorbol, the parent alcohol is shown below. Phorbol esters also have important effects on leukocytes and on the immune system of the intact animal. There appears to be a specific receptor for phorbol esters on T cells, a finding that may account for the selective toxicity of phorbol esters for T cells. The mechanism of tumor promotion by phorbol esters is still largely unknown, but findings suggest an initial cell membrane interaction (often with stimulation of second messenger synthesis and increased protein kinase activity), with subsequent effects on nuclear regulatory events.

Use

PHORBOL 12-MYRISTATE 13-ACETATE is sensitive to acids and alkalis. .

178 supplier list of "PHORBOL 12-MYRISTATE 13-ACETATE"

  • Product Name:Phorbol-12-Myristate-13-Acetate
  • Products Intro:Purity: 0.98 | Package: 10mg;20mg;50mg;100mg;500mg | CustNote: Can Be Customized in Bulk
  • Company Type: Reagent
  • Country/Region: CHINA
  • Main Products: Mogroside V,Methysticin,Sarsasapogenin,20(R)-Ginsenoside Rg3,Ginsenoside CK
  • Product Name:Phorbol
  • Products Intro:Purity: 98% | Package: 1G 5G;10G 100G;1KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: SARMS,isrib,nootropic,natural compounds,peptides

$0.00-0.00 / 1kg

  • Product Name:PHORBOL 12-MYRISTATE 13-ACETATE
  • Products Intro:Purity: >=98% | Package: 1kg;|5kg;|25kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Ceramides,Phytosphingosine,Ectoine,Complex ceramide emulsion,Water soluble ceramides

$0.00/ 25KG

  • Product Name:PHORBOL 12-MYRISTATE 13-ACETATE
  • Products Intro:Purity: 99% | Package: 25KG
  • Company Type: Service provider
  • Country/Region: CHINA
  • Main Products: carbomer,lead acetate,phenylacetamide,Xylazine,Xylazine hcl
  • Product Name:12-O-tetradecanoylphorbol-13-acetate (TPA)
  • Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:PMA
  • Products Intro:Purity: As coa | Package: As request | CustNote: 16561-29-8
  • Company Type: Trader
  • Country/Region: CHINA

$1.00/ 1kg

  • Product Name:PHORBOL 12-MYRISTATE 13-ACETATE
  • Products Intro:Purity: 95%-99% | Package: 1kg;1USD
  • Company Type: Reagent
  • Country/Region: CHINA
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Product Name:Phorbol-12-Myristate-13-Acetate
  • Products Intro:Purity: 0.99 | Package: 1g;25g;1kg;25kg;100kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:PMA
  • Products Intro:Package: 25mg | CustNote: BOC Sciences also provides custom synthesis services for PMA.
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Product Name:PHORBOL 12-MYRISTATE 13-ACETATE
  • Products Intro:Purity: 0.98 | Package: 1kg,2kg,5kg,10kg,25kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
You can find PHORBOL 12-MYRISTATE 13-ACETATE suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

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