Parthenolide manufacturers and suppliers

Parthenolide suppliers

Properties

Melting point:: 115-116 °C (lit.)

alpha: D20 -81.4° (c = 1.04 in chloroform); D22 -71.4° (c = 0.220 in CH2Cl2)

Boiling point:: 394.1±42.0 °C(Predicted)

Density: 1.13±0.1 g/cm3(Predicted)

storage temp.: -20°C

solubility: Soluble in DMSO (up to 100 mg/ml) or in Ethanol (up to 20 mg/ml)

form: White solid

color: White

Merck: 14,7048

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.

InChI: InChI=1S/C15H20O3/c1-9-5-4-8-15(3)13(18-15)12-11(7-6-9)10(2)14(16)17-12/h5,11-13H,2,4,6-8H2,1,3H3/b9-5+/t11-,12-,13+,15+/m0/s1

InChIKey: KTEXNACQROZXEV-PVLRGYAZSA-N

SMILES: O1C(=O)C(=C)[C@]2([H])CCC(C)=CCC[C@@]3(C)O[C@]3([H])[C@@]12[H] |t:10|

LogP: 2.424 (est)

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H317

Precautionary statements: P280-P302+P352

Hazard Codes: Xi,C,F

Risk Statements: 11-34

Safety Statements: 22-24/25-45-36/37/39-26-16

WGK Germany: 3

RTECS: LY4220000

HS Code: 29322090

Use

Parthenolide is a sesquiterpene lactone from the plant feverfew (T. parthenium). It inhibits the growth of the promastigote form of L. amazonensis (IC50 = 3.6 μg/ml). Parthenolide also induces apoptosis in cancer cells, at least in part by inhibiting NF-κB- and STAT-mediated anti-apoptotic gene transcription. This compound has also been shown to block inflammation by inhibiting signaling through NF-κB. Inhibition of NF-κB by parthenolide can be achieved by direct binding of the pattern recognition receptor NOD2 by parthenolide.

You can find Parthenolide suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.