Ribavirin suppliers
Ribavirin
- CAS:
- 36791-04-5
- MF:
- C8H12N4O5
- MW:
- 244.21
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Properties
- Melting point:
- 174-176°C
- alpha
- D25 -36.5° (c = 1 in water); D20 -38° (c = 1 in water)
- Boiling point:
- 387.12°C (rough estimate)
- Density
- 1.4287 (rough estimate)
- refractive index
- -36 ° (C=1, H2O)
- storage temp.
- 2-8°C
- solubility
- Freely soluble in water, slightly soluble in ethanol (96 per cent), slightly soluble or very slightly soluble in methylene chloride. It shows polymorphism (5.9).
- form
- White solid
- pka
- 12.95±0.70(Predicted)
- color
- White
- Water Solubility
- >=10 g/100 mL at 19 ºC
- Merck
- 14,8198
- BCS Class
- 3
- Stability:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.
- InChIKey
- IWUCXVSUMQZMFG-AFCXAGJDSA-N
- LogP
- -2.260 (est)
Safety Information
- Symbol(GHS)
GHS08
- Signal word
- Danger
- Hazard statements
- H341-H360FD
- Precautionary statements
- P201-P308+P313
- Hazard Codes
- T,Xi
- Risk Statements
- 61-36/38
- Safety Statements
- 53-22-45-37/39-26
- WGK Germany
- 3
- RTECS
- XZ4250000
- HS Code
- 29349990
- Toxicity
- LD50 i.p. in mice: 1.3 g/kg; orally in rats: 5.3 g/kg (Witkowski, 1972)
Use
1, Ribavirin can be subject to phosphorylation in red blood cells to generate ribavirin monophosphate, diphosphate and triphosphate, wherein the ribavirin monophosphate is the strong inhibitor of the inosine monophosphate dehydrogenase which can inhibit cellular guanylate synthesis, decrease the tri-phosphorylation of the intracellular guanylate triphosphate, and blocking the synthesis of viral nucleic acid. 2, ribavirin triphosphate can inhibit the influenza virus RNA polymerase and interfere with viral replication. 3, ribavirin triphosphate can inhibit the synthesis of viral mRNA 5 'end and transcriptase, thereby inhibiting the DNA and RNA synthesis. It has inhibitory effect on various kinds of viruses (including DNA viruses and RNA viruses). It also has prevention and treatment effect on the influenza, adenovirus pneumonia, hepatitis, herpes, and measles and is also effective on treating the epidemic hemorrhagic fever. 4, it is mainly excreted through urine in the prototype with also a small amount of de-sugarized ribavirin metabolites with a small amount discharged from the feces. The above information is edited by the Chemicalbook of Dai Xiongfeng.
483 supplier list of "Ribavirin"
$0.00/ 1kg
- Product Name:Ribavirin
- Products Intro:Purity: 99% | Package: 1kg
- Company Type: Trader
- Country/Region: CHINA