Roflumilast manufacturers and suppliers

Roflumilast suppliers

Properties

Melting point:: 158°C

Boiling point:: 430.6±45.0 °C(Predicted)

Density: 1.471±0.06 g/cm3(Predicted)

storage temp.: -20°C

solubility: DMSO: soluble20mg/mL, clear

pka: 9.89±0.70(Predicted)

form: powder

color: white to beige

Merck: 14,8249

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

InChI: InChI=1S/C17H14Cl2F2N2O3/c18-11-6-22-7-12(19)15(11)23-16(24)10-3-4-13(26-17(20)21)14(5-10)25-8-9-1-2-9/h3-7,9,17H,1-2,8H2,(H,22,23,24)

InChIKey: MNDBXUUTURYVHR-UHFFFAOYSA-N

SMILES: C(NC1C(Cl)=CN=CC=1Cl)(=O)C1=CC=C(OC(F)F)C(OCC2CC2)=C1

Safety Information

Symbol(GHS): GHS07

Signal word: Warning

Hazard statements: H315-H319-H335

Precautionary statements: P261-P264-P271-P280-P302+P352-P305+P351+P338

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26

WGK Germany: 3

RTECS: CV3325600

HS Code: 2933.39.4100

Use

Roflumilast is taken orally and is metabolized by cytochrome oxidase P45(CYP)3A4 and CYP1A2 enzyme into N-oxide. Roflumilast N-oxides activity is only 2-3 times weaker than that of roflumilast, and it also has relatively high PDE-4 selectivity. 90% of PDE-4 inhibition in the body is achieved by roflumilast N-oxide, while the other 10% is achieved by the original drug. A daily 500ng oral dose of roflumilast for a healthy person will produce a free blood concentration of roflumilast N-oxide in 24 hours of about 1-2 nmolL-1, and its serum protein binding rate is about 97%. Smoking has little impact on roflumilasts pharmacokinetics. Roflumilast mostly affects inflammation cells related to asthma, including eosinophils, neutrophils, and mast cells. This drug can specifically affect a certain enzyme that participates in smooth muscle contraction, it can prevent cAMP decomposition, thus preventing the signal transduction for inflammatory reactions, and it is anti-inflammatory, giving it relatively good curative effects in clinically treating asthma and COPD. Roflumilast can also significantly extend the deterioration of respiratory symptoms while also dramatically increasing patients quality of life.

You can find Roflumilast suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.