Request for quotation
My ChemicalBook
My ChemicalBook
Welcome to chemicalbook!
400-158-6606

Get started now

or
My Account
Buyers
Inquiry management
Suppliers
Quotation management

Sodium bicarbonate

CAS:
144-55-8
MF:
CHNaO3
MW:
84.01

Properties

Melting point:
>300 °C(lit.)
Boiling point:
851°C
Density 
2.16 g/mL at 25 °C (lit.)
refractive index 
1.500
storage temp. 
2-8°C
solubility 
H2O: 1 M at 20 °C, clear, colorless
form 
solution (7.5%)
Specific Gravity
2.159
color 
White
PH Range
7.8 - 8.2
PH
8.3 (0.1molfreshly prepared)
pka
(1) 6.37, (2) 10.25 (carbonic (at 25℃)
Odor
Odorless
Water Solubility 
9 g/100 mL (20 ºC)
Decomposition 
50 °C
Merck 
14,8583
BRN 
4153970
Stability:
Stable.

Safety Information

Symbol(GHS) 

GHS07
Hazard statements 
H319-H303
Precautionary statements 
P264-P280i-P305+P351+P338-P337+P313
Safety Statements 
24/25
WGK Germany 
1
RTECS 
VZ0950000
TSCA 
Yes
HS Code 
28363000
Toxicity
LD50 orally in Rabbit: 4220 mg/kg

Use

Sodium bicarbonate is generally used in pharmaceutical formulations as a source of carbon dioxide in effervescent tablets and granules. It is also widely used to produce or maintain an alkaline pH in a preparation. In effervescent tablets and granules, sodium bicarbonate is usually formulated with citric and/or tartaric acid; combinations of citric and tartaric acid are often preferred in formulations as citric acid alone produces a sticky mixture that is difficult to granulate, while if tartaric acid is used alone, granules lose firmness. When the tablets or granules come into contact with water, a chemical reaction occurs, carbon dioxide is evolved, and the product disintegrates. Melt granulation in a fluidized bed dryer has been suggested as a one-step method for the manufacture of effervescent granules composed of anhydrous citric acid and sodium bicarbonate, for subsequent compression into tablets. Tablets may also be prepared with sodium bicarbonate alone since the acid of gastric fluid is sufficient to cause effervescence and disintegration. Sodium bicarbonate is also used in tablet formulations to buffer drug molecules that are weak acids, thereby increasing the rate of tablet dissolution and reducing gastric irritation. The effects of tablet binders, such as polyethylene glycols, microcrystalline cellulose, silicified microcrystalline cellulose, pregelatinized starch, and povidone, on the physical and mechanical properties of sodium bicarbonate tablets have also been investigated.( 8,9) Additionally, sodium bicarbonate is used in solutions as a buffering agent for erythromycin, lidocaine, local anesthetic solutions, and total parenteral nutrition (TPN) solutions. In some parenteral formulations, e.g. niacin, sodium bicarbonate is used to produce a sodium salt of the active ingredient that has enhanced solubility. Sodium bicarbonate has also been used as a freeze-drying stabilizer and in toothpastes. Recently, sodium bicarbonate has been used as a gas-forming agent in alginate raft systems and in floating, controlledrelease oral dosage forms for a range of drugs. Tablet formulations containing sodium bicarbonate have been shown to increase the absorption of paracetamol, and improve the stability of levothyroxine. Sodium bicarbonate has also been included in formulations of vaginal bioadhesive tablets and in carbon dioxide releasing suppositories. Therapeutically, sodium bicarbonate may be used as an antacid, and as a source of the bicarbonate anion in the treatment of metabolic acidosis. Sodium bicarbonate may also be used as a component of oral rehydration salts and as a source of bicarbonate in dialysis fluids; it has also been suggested as a means of preventing radiocontrast-induced nephrotoxicity. Sodium bicarbonate is used in food products as an alkali or as a leavening agent, e.g. baking soda.

569 supplier list of "Sodium bicarbonate"

  • Product Name:Sodium bicarbonate
  • Products Intro:Purity: FCC 99.5% | Package: 1KG;2USD
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: 86-0551-65418684 18949823763

    US $6.00/ 25KG

  • Product Name:Sodium bicarbonate
  • Products Intro:Purity: 99%|Package: 25KG;6USD
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 008613573296305

    US $17.00/ 1KG

  • Product Name:Sodiu Mbicarbonate
  • Products Intro:Purity: 99|Package: 1KG;17USD
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0086-18062075862
  • Main Products: Pharmaceutical raw material,Organic Synthesis Intermediate,Steroids raw powder,Peptides powder

    US $15.00-10.00 / 1KG

  • Product Name:Sodium bicarbonate
  • Products Intro:Purity: 99%+ HPLC|Package: 1KG;15USD|100KG;12USD|1000KG;10USD
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +8613111626072 (WhatsApp)
  • Main Products: APIS,Pharmaceutical raw materials,Cosmetic raw materials,Industrial additives,Experimental reagent
  • Product Name:Sodium Bicarbonate Food Grade
  • Products Intro:Package: 25kgs/50kgs/200kgs
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 18942506900

    US $100.00/ 1KG

  • Product Name:Sodium bicarbonate
  • Products Intro:Purity: 99|Package: 1KG;100USD
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • Main Products: phenactin,4-Methylpropiophenone 5337-93-9,288573-56-8,443998-65-0
  • Product Name:Sodium bicarbonate
  • Products Intro:Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-571-85586718
  • Product Name:144-55-8
  • Products Intro:Purity: 0.99 | Package: 25KG,5KG;1KG;500G
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0371-55170693
  • Product Name:Sodium bicarbonate
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-021-57951555
  • Product Name:Sodium bicarbonate
  • Products Intro:Purity: As coa | Package: As request | CustNote: 144-55-8
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 008615858145714

Sodium bicarbonate Related Search:

Magnesium carbonatePotassium bicarbonateAmmonium bicarbonatePotassium carbonateSodium carbonateHydrogenSodiumSODIUM CARBONATE, MONOHYDRATESodium bicarbonateSodium percarbonateSODIUM SESQUICARBONATE DIHYDRATEDIHYDROXYALUMINUM SODIUM CARBONATEPOTASSIUM SODIUM CARBONATESODIUM CARBONATE-13ChydroxideESCHKA'S MIXTURESODIUM BICARBONATE, [14C]
HomePage | About Us | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Product Catalog | Links| Pricacy| Terms| Product Manufacturers| New Products
Copyright © 2019 ChemicalBook All rights reserved.