TRIOLEIN manufacturers and suppliers

TRIOLEIN suppliers

Properties

Melting point:: -5,5°C

Boiling point:: 235-240 °C18 mm Hg(lit.)

Density: 0.91 g/mL(lit.)

refractive index: n20/D 1.470

Flash point:: 330 °C

storage temp.: -20°C

solubility: chloroform: 0.1 g/mL, clear, colorless

form: Liquid

color: Clear Pale Yellow

Merck: 14,9732

BRN: 1718692

Dielectric constant: 3.2（26℃）

Stability:: Stability Stable, but air and light sensitive. Incompatible with strong oxidizing agents.

LogP: 23.444 (est)

Safety Information

Symbol(GHS): GHS02,GHS07

Signal word: Danger

Hazard statements: H225-H302+H312+H332

Precautionary statements: P210-P280

Hazard Codes: F,Xn

Risk Statements: 11-20/21/22-53

Safety Statements: 24/25-39-26

RIDADR: UN 1282 3/PG 2

WGK Germany: -

RTECS: RG1936500

F: 10-23

TSCA: Yes

HS Code: 29161500

Use

Triolein is used in injectable preparations, in enteric coatings for oral preparations, and in personal care products. Chronic exposure may cause nausea and vomiting, and higher exposures may cause unconsciousness. The Cosmetic Ingredient Review (CIR) Expert Panel found that dermal application of triolein was not associated with significant irritation, and no evidence of sensitization or photosensitization was observed. Ocular exposures were found to be only mildly irritating to eyes. Triolein has not been found to be genotoxic in a number of in vitro and in vitro assay systems. Subcutaneous injections of triolein in rats showed no tumors at the injection site. The CIR Expert Panel also noted that metabolism data indicated that glyceryl triesters (including triolein) followed the same metabolic pathways as fats in food. They were split into monoglycerides, free fatty acids, and glycerol, all of which were absorbed into the intestinal mucosa and metabolized further. Therefore, oral exposure to these compounds was not found to be a concern. A triolein-based amphotericin emulsion showed better safety with a higher LD50 in rats as compared with the conventional amphotericin deoxycholate.

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