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Tacrolimus

CAS:
104987-11-3
MF:
C44H69NO12
MW:
804.02

Properties

Melting point:
113-115°C
Boiling point:
871.7±75.0 °C(Predicted)
Density 
1.19±0.1 g/cm3(Predicted)
Flash point:
2℃
storage temp. 
−20°C
solubility 
DMSO: >3 mg/mL
pka
9.97±0.70(Predicted)
form 
solid
color 
white
Water Solubility 
Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.
InChIKey
QJJXYPPXXYFBGM-LFZNUXCKSA-N

Safety Information

Symbol(GHS) 

GHS06,GHS02,GHS07
Signal word 
Danger
Hazard statements 
H301-H225-H302+H312+H332-H319
Precautionary statements 
P210-P280-P305+P351+P338-P264-P270-P301+P310a-P321-P405-P501a
Hazard Codes 
T,Xi,Xn,F
Risk Statements 
25-36/37/38-36-20/21/22-11
Safety Statements 
45-36-26-36/37-16-60-20
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
KD4201200
HazardClass 
6.1
HS Code 
29349990

Use

1 Ruzicka T, Assmann T, Homey B. Tacrolimus: The drug for the turn of the millennium? Arch Dermatol 1999; 135: 574580. Lawrence ID. Tacrolimus (FK506): experience in dermatology. Dermatol Ther 1998; 5: 7484. Michel G, Kemeny L, Homey B, Ruzicka T. FK506 in the treatment of inflammatory skin disease: promises and perspectives. Immunol Today 1996; 17: 106108. Bieber T. Topical tacrolimus (FK506): a new milestone in the management of atopic dermatitis. J Allergy Clin Immunol 1998; 102: 555557. Ruzicka T, Bieber T, Schopf E et al. A short-term trial of tacrolimus ointment for atopic dermatitis. N Engl J Med 1997; 337: 816821. Alaiti S, Kang S, Fiedler VC et al. Tacrolimus (FK506) ointment for atopic dermatitis: a phase I study in adults and children. J Am Acad Dermatol 1998; 38: 6976. Hanifin JM, Chan S. Biochemical and immunologic mechanisms in atopic dermatitis: New targets for emerging therapies. J Am Acad Dermatol 1999; 41: 7277. Laurema AI, Granlund H, Reitamo S. Use of the newer immunosuppressive agents in dermatology. Bio Drugs 1997; 8: 96106. Shirbacheh MV, Jones JW, Harralson TA et al. Pharmacokinetics of intra-arterial delivery of tacrolimus to vascularly isolated rabbit forelimb. J Pharmacol Exp Ther 1999; 289: 11961201. Perego C, Lattuada D, Casnici C et al. Evidence that SMS 201995 enhances the immunosuppressive effect of FK506. Int J Immunopharmacol 1998; 20: 479490. Fleischer AB. Treatment of atopic dermatitis: Role of tacrolimus ointment as a topical noncorticosteroid therapy. J Allergy Clin Immunol 2000; 104: S126S130. Wollenberg A, Bieber T. FK-506/Tacrolimus. In: Burg G, Dummer RG, editors. Strategies for Immunointerventions in Dermatology. Springer-Verlag, Heidelberg, 1997: 5357. Columbo M, Bochner BS, Marone G. Human skin mast cells express functional beta1 integrins that mediate adhesion to extracellular martix proteins. J Immunol 1995; 154: 60586064. Panhans-Gro A, Novak N, Kraft S et al. Human epidermal Langerhans cells are targets for the immnosuppressive macrolide tacrolimus (FK506). J Allergy Clin Immunol 2001; 107: 345352. Reitamo S. Tacrolimus: a new topical immunomodulatory therapy for atopic dermatitis. J Allergy Clin Immunol 2001; 107: 445448. Nagai H, Hiyama H, Matsuo A et al. FK-506 and cyclosporin A potentiate the IgE antibody production by contact sensitization with hapten in mice. J Pharmacol Exp Ther 1997; 283: 321327. Homey B, Assmann T, Vohr H-W et al. Topical FK506 suppresses cytokine and costimulatory molecule expression in epidermal and local draining lymph node cells during primary skin immune responses. J Immunol 1998; 160: 53315340. Leung DYM, Soter NA. Cellular and immunologic mechanisms in atopic dermatitis. J Am Acad Dermatol 2001; 44: S1S12. Nash RA, Etzioni R, Storb R et al. Tacrolimus (FK506) alone or in combination with methotrexate or methylprednisolone for the prevention of acute graft-versus-host disease after marrow transplantation from HLA-matched siblings: a single-center study. Blood 1995; 85: 37463753. Nielsen FT, Leyssac PP, Kemp E et al. Nephrotoxicity of FK-506 in the rat. Studies on glomerular and tubular function, and on the relationship between efficacy and toxicity. Nephrol Dial Transplant 1995; 10: 334340. Nasr IS. Topical tacrolimus in dermatology. Clin Exp Dermatol 2000; 25: 250254. Compendium of Pharmaceuticals Specialties, 35th edn. Webcom Limited, Toronto, 2000: 12871292. Manez R, Jain A, Marino IR, Thomson AW. Comparative evaluation of tacrolimus (FK506) and cyclosporin A as immunosuppressive agents. Transplant Rev 1995; 9: 6376. Nousari Hossein C, Sragovich A, Kimyai-Asadi A et al. Mycophenolate mofetil in autoimmune and inflammatory skin disorders. J Am Acad Dermatol 1999; 40: 265268. Ohashi Y, Minegishi M, Fujie H et al. Successful treatment of steroid-resistant severe acute GVHD with 24-h continuous infusion of FK506. Bone Marrow Transplant 1997; 19: 625627. Jegasothy BV, Ackerman CD, Todo S et al. Tacrolimus (FK506) A new therapeutic agent for severe recalcitrant psoriasis. Arch Dermatol 1992; 128: 781785.

301 supplier list of "Tacrolimus"

  • Product Name:104987-11-3
  • Products Intro:Purity: 0.99 | Package: 25KG,5KG;1KG;500G
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0371-55170693
  • Product Name:Tacrolimus
  • Products Intro:Purity: 0.99 | Package: 25KG;5KG;1KG;500G
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 0371-55170695
  • Product Name:Tacrolimus
  • Products Intro:Purity: 99.98% | Package: 1KG;USD|5KG;USD|25KG;USD
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +17326109938
  • Product Name:Tacrolimus
  • Products Intro:Purity: 97%(Min,HLPC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +86-571-85586718
  • Product Name:Fujimycin
  • Products Intro:Purity: 99% | Package: 100g/ bag, 2 kg/ bag, 25kg/ carton or as required | CustNote: White or off-white crystalline powder
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +8615102730682; +8618874586545
  • Product Name:Tacrolimus
  • Products Intro:Purity: 99%min | Package: 1KG;10KG;100KG;500KG;100g | CustNote: ISO certified
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 025-85710122 17714198479
  • Product Name:Tacrolimus
  • Products Intro:Purity: 0.99 | Package: 5G,10G,25G,50G,100G,250G,1KG
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86 21 5161 9050/ 5187 7795

    US $10/ 1KG

  • Product Name:Tacrolimus
  • Products Intro:Purity: 99%|Package: 1KG;10USD
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: +8613292890173
  • Main Products: pmk powder CAS 13605-48-6,Bmk powder CAS 16648-44-5,Cas 99918-43-1 N-phenylpiperidin-4-amine,dihydrochloride
  • Product Name:Tacrolimus
  • Products Intro:Package: 20mg
  • Type of Enterprise: Trader
  • Country/Region: CHINA
  • TEL: 18017610038

    US $1.00/ 1KG

  • Product Name:Tacrolimus
  • Products Intro:Purity: 96% | Package: 1KG;1USD
  • Type of Enterprise: Reagent
  • Country/Region: CHINA
  • TEL: +86-371-86658258
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information

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