Tacrolimus manufacturers and suppliers

Tacrolimus suppliers

Properties

Melting point:: 113-115°C

Boiling point:: 871.7±75.0 °C(Predicted)

Density: 1.19±0.1 g/cm3(Predicted)

Flash point:: 2℃

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: DMSO: >3 mg/mL

form: solid

pka: 9.97±0.70(Predicted)

color: white

Water Solubility: Freely soluble in DMSO or ethanol. Poorly soluble in water.Soluble in dimethyl sulfoxide, ethanol, water, acetone, chloroform, ethyl acetate, ether, methanol and dimethyl formamide.

BCS Class: 2

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

InChIKey: QJJXYPPXXYFBGM-LFZNUXCKSA-N

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H301-H361f-H373

Precautionary statements: P202-P260-P264-P270-P280-P301+P310

Hazard Codes: T,Xi,Xn,F

Risk Statements: 25-36/37/38-36-20/21/22-11

Safety Statements: 45-36-26-36/37-16-60-20

RIDADR: UN 2811 6.1/PG 3

WGK Germany: 3

RTECS: KD4201200

HazardClass: 6.1

HS Code: 29349990

Use

FK-506 (Tacrolimus) is a macrolide immunosuppressive drug that is mainly used after allogeneic organ transplant to reduce the activity of the patient's immune system. Tacrolimus (fujimycin) was discovered as a potent inhibitor of IL2 production in a targeted search for novel immunosuppressants. Tacrolimus acts by blocking T cell proliferation in vitro by inhibiting the generation of several lymphokines, notably the original target IL-2. Tacrolimus inhibits the activity of FK-506 binding protein, Ca2+-dependent phosphatase and calcineurin, and activates NF-κB through phosphorylation and degradation of IκBα.

You can find Tacrolimus suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.