Telithromycin manufacturers and suppliers

Telithromycin suppliers

Properties

Melting point:: 176-188 C

Boiling point:: 966℃

Density: 1.26±0.1 g/cm3(Predicted)

RTECS: KF4674500

Flash point:: >110°(230°F)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)

pka: 10.85±0.70(Predicted)

form: Solid

color: White to Light Beige

Water Solubility: Sparingly soluble in water

Safety Information

Symbol(GHS): GHS07,GHS09

Signal word: Warning

Hazard statements: H315-H319-H335-H400-H410

Precautionary statements: P261-P280a-P304+P340-P305+P351+P338-P405-P501a

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 26-36

HazardClass: 9

Use

Telithromycin (Ketek) is an orally bioavailable macrolide.The antibiotic is semisynthetic. Telithromycin is classifiedas a ketolide, and it differs chemically from the macrolidegroup of antibacterials by the lack of α-L-cladinose at 3-position of the erythronolide A ring, resulting in a 3-ketofunction. It is further characterized by imidazolyl andpyridyl rings inked to the macrolide nucleus through a butylchain. The mechanism of action of telithromycin is the sameas that of the macrolide class.Telithromycin causes a blockade of protein synthesis bybinding to domains II and V of 23S rRNA of the 50S ribosomalsubunit. Because telithromycin binds at domain II,activity against Gram-positive cocci is retained in the presenceof resistance mediated by methylases that alter thedomain V binding site. The antibiotic is also believed to inhibitthe assembly of ribosomes. Resistance to telithromycinoccurs because of riboprotein mutations.

You can find Telithromycin suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.