Vincristine sulfate manufacturers and suppliers

Vincristine sulfate suppliers

Properties

Melting point:: 300 °C

Boiling point:: 273-281 °C

alpha: D26 +8.5° (c = 0.8)

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: methanol: soluble20mg/mL

form: lyophilized powder

color: white to off-white

Water Solubility: >=1 g/100 mL at 24 ºC

BRN: 3924631

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in distilled water may be stored at -20° for up to 3 months.

InChIKey: AQTQHPDCURKLKT-HSMPTBRCNA-N

Safety Information

Symbol(GHS): GHS06,GHS08

Signal word: Danger

Hazard statements: H300-H341-H361fd

Precautionary statements: P202-P264-P270-P280-P301+P310-P405

Hazard Codes: T

Risk Statements: 61-36/37/38-63-23/24/25-68-62-25

Safety Statements: 22-24/25-53-45-37/39-26-36/37/39-36/37

RIDADR: UN 2811 6.1/PG 2

WGK Germany: 3

RTECS: OH6340000

F: 8-10

HazardClass: 6.1(a)

PackingGroup: II

HS Code: 29399990

Toxicity: LD50 intraperitoneal in mouse: 3mg/kg

Use

Vincristine sulfate is available as a 1-mg/mL solution in 1-,2-, and 5-mL vials for IV administration in acute leukemiaand as part of a multidrug regime for Hodgkin’s and neuroblastoma, Ewing sarcoma, Wilms tumor, soft tissuesarcoma, testicular cancer, liver cancer, and head and neckcancers. It has also been utilized in treating pediatric cancer.Vincristine is highly protein bound (75%) and may also bindto platelets that contain large amounts of tubulin. Numerousmetabolites have been detected and several have been identified,one of which is the 4-O-desacetyl derivative. The metabolismthat does occur is believed to largely be mediatedby CYP3A. Elimination occurs primarily in the bile with aterminal elimination half-life of 23 to 85 hours. The mostcommonly seen toxicity for vincristine is a dose-limitingneurotoxicity caused by effects on axonal microtubules.Symptoms are variable and include peripheral neuropathy,ataxia, seizure, bone pain, and coma. Constipation is also acommonly seen toxicity, and laxatives may be used prophylactically.Other toxicities include alopecia, skin rash, mildmyelosuppression, secretion of antidiuretic hormone,azospermia, and amenorrhea.

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