Zalcitabine manufacturers and suppliers

Zalcitabine suppliers

Properties

Melting point:: 217-218 °C(lit.)

alpha: D25 +81° (c = 0.635 in water)

Boiling point:: 350.9°C (rough estimate)

Density: 1.2605 (rough estimate)

refractive index: 78 ° (C=0.5, H2O)

storage temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

solubility: DMSO (Slightly, Heated), Methanol (Slightly), Water (Slightly, Sonicated)

form: powder

pka: 14.44±0.10(Predicted)

color: colorless

Water Solubility: 5-10 g/100 mL at 19 ºC

Merck: 14,10109

BRN: 654956

Stability:: Stable. Combustible. Incompatible with strong oxidizing agents.

InChIKey: WREGKURFCTUGRC-POYBYMJQSA-N

Safety Information

Symbol(GHS): GHS08

Signal word: Warning

Hazard statements: H351

Precautionary statements: P281

Hazard Codes: Xn,C

Risk Statements: 40-36/37-34

Safety Statements: 22-36-45-36/37/39-27-26

WGK Germany: 3

RTECS: HA3870000

F: 10-23

HS Code: 2934990002

Use

Zalcitabine, 2',3'-dideoxycytidine or ddCyd, is an analog ofcytosine that demonstrates activity against HIV-1 and HIV-2,including strains resistant to AZT. The potency (in peripheralblood mononuclear cells) is similar to that of AZT, but thedrug is more active in populations of monocytes andmacrophages as well as in resting cells.The oral bioavailability of zalcitabine is over 80% in adultsand less in children.The major dose-limiting side effect isperipheral neuropathy, characterized by pain, paresthesias,and hypesthesia, beginning in the distal lower extremities.These side effects are typically evident after several months oftherapy with zalcitabine. A potentially fatal pancreatitis is anothertoxic effect of treatment with ddC. The drug has beenapproved for the treatment of HIV infection in adults with advanceddisease who are intolerant to AZT or who have diseaseprogression while receiving AZT. ddC is combined with AZTfor the treatment of advanced HIV infection.

You can find Zalcitabine suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.