Crizotinib manufacturers and suppliers

Crizotinib suppliers

Properties

Melting point:: 192 °C

Boiling point:: 599.2±50.0 °C(Predicted)

Density: 1.47±0.1 g/cm3(Predicted)

storage temp.: room temp

solubility: Soluble in DMSO (up to 25 mg/ml with warming) or in Ethanol (up to 25 mg/ml with warming)

pka: 9.81±0.10(Predicted)

form: powder

color: white to tan

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

InChIKey: KTEIFNKAUNYNJU-GFCCVEGCSA-N

SMILES: C1(N)=NC=C(C2=CN(C3CCNCC3)N=C2)C=C1O[C@@H](C1=C(Cl)C=CC(F)=C1Cl)C

Safety Information

Symbol(GHS): GHS07,GHS08,GHS09

Signal word: Warning

Hazard statements: H317-H319-H341-H400

Precautionary statements: P201-P273-P280-P302+P352-P305+P351+P338-P308+P313

Safety Statements: 24/25

RIDADR: UN 3077 9 / PGIII

WGK Germany: 3

HazardClass: IRRITANT

HS Code: 29333990

Use

Crizotinib (Xalkori(R), Pfizer), approved in 2011, was the first approved inhibitor targeting anaplastic lymphoma kinase (ALK). ROS protooncogene 1-encoded kinase (ROS1) of the tyrosine kinase insulin receptor class and MET proto-oncogene-encoded kinase of the hepatocyte growth factor receptor (HGFR) class are other kinases targeted by crizotinib.When approved in 2011, crizotinib was the first drug specifically targeting NSCLC patients. However, resistance to crizotinib was usually observed in approximately 8 months after initial application and more than half of crizotinib-treated patients experienced gastrointestinal side effects. In 2016,crizotinib was additionally approved for ROS1-positive NSCLC by FDA.

You can find Crizotinib suppliers, manufacturers, and distributors from countries such as China, United States and the India here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.