HERBIMYCIN A manufacturers and suppliers

HERBIMYCIN A suppliers

Properties

Melting point:: 229-231 °C

Boiling point:: 752℃

Density: 1.19±0.1 g/cm3(Predicted)

Flash point:: >110°(230°F)

storage temp.: −20°C

solubility: DMSO: 7.5 mg/mL DMSO stock solution can be diluted in phosphate buffered saline. The ratio of buffer:DMSO should be greater than 500:1.

pka: 8.56±0.70(Predicted)

form: powder

color: yellow

Sensitive: Light Sensitive & Hygroscopic

BRN: 4834067

Stability:: Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.

Safety Information

Hazard Codes: Xi

Risk Statements: 36/37/38

Safety Statements: 22-24/25-36-26

WGK Germany: 3

RTECS: LX8930000

F: 10-21

HS Code: 29419000

Use

Herbimycin A is a benzoquinone ansamycin antibiotic from Streptomyces. It has herbicidal activity and acts as a cell-permeable inhibitor of non-receptor tyrosine kinases and the heat shock protein Hsp90. Herbimycin A inhibits Bcr-Abl with an IC50 value of 5 μM, a concentration that also effectively blocks Src, Yes, Fps, Ros, and ErbB but not protein kinases (PK) PKA, PKC, Rac, Myc, or Raf. Presumably through its effects on tyrosine kinase signaling, herbimycin A also impairs endothelial cell proliferation in the context of angiogenesis, NF-κB activation, phosphorylation of phospholipase C-γ1, and eggshell formation in schistosome parasites. Ansamycins, including herbimycin A and geldanamycin , bind Hsp90 and destabilize client proteins, including Src, Bcr-Abl, and ErbB2, leading to their ubiquitination and proteasomal degradation.

You can find HERBIMYCIN A suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.