Ibrutinib manufacturers and suppliers

Ibrutinib suppliers

Properties

Melting point:: 153-158°C

Boiling point:: 715.0±60.0 °C(Predicted)

Density: 1.34

storage temp.: -20°C

solubility: Soluble in DMSO ( up to at least 25 mg/ml)

pka: 4.09±0.30(Predicted)

form: solid

color: White or off-white

Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

InChIKey: XYFPWWZEPKGCCK-GOSISDBHSA-N

SMILES: C(N1CCC[C@@H](N2C3C(C(C4=CC=C(OC5=CC=CC=C5)C=C4)=N2)=C(N)N=CN=3)C1)(=O)C=C

Safety Information

Symbol(GHS): GHS07,GHS06

Signal word: Danger

Hazard statements: H360-H319-H315-H335-H302

Precautionary statements: P264-P280-P302+P352-P321-P332+P313-P362-P264-P270-P301+P312-P330-P501-P264-P280-P305+P351+P338-P337+P313P

Use

ibrutinib is a kind of bruton tyrosine kinase (btk) inhibitor, it could be used for the treatment of chronic lymphocytic leukemia (cll) and mantle cell lymphoma (mcl). Ibrutinib is a potent inhibitor of BTK that binds covalently to Cys-481 in the active site of BTK, resulting in inhibition of kinase activity. Ibrutinib does have significant activity against 19 other kinases, including seven with a cognate cysteine residue. These include BLK, BMX, ITK, TEC, EGFR, ERBB2, and JAK3.

You can find Ibrutinib suppliers, manufacturers, and distributors from countries such as CHINA, India and the United States here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.