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ChemicalBook >> CAS DataBase List >>Neratinib

Neratinib suppliers

Neratinib

CAS:
698387-09-6
MF:
C30H29ClN6O3
MW:
557.04

Properties

Melting point:
185-187°C
Boiling point:
757.0±60.0 °C(Predicted)
Density 
1.33
storage temp. 
Refrigerator
solubility 
Chloroform (Slightly), DMSO (Slightly, Heated, Sonicated), Methanol (Slightly, Heated)
form 
Off-white solid.
pka
12.37±0.43(Predicted)
color 
Pale Yellow to Yellow

Safety Information

Symbol(GHS) 
GHS hazard pictograms
GHS05
Signal word 
Danger
Hazard statements 
H314-H290
Precautionary statements 
P501-P234-P264-P280-P390-P303+P361+P353-P301+P330+P331-P363-P304+P340+P310-P305+P351+P338+P310-P406-P405
HS Code 
29334900

Use

Neratinib developed by US Wyeth company is an irreversible epidermal growth factor receptor(EGFR) inhibitor. It is a multiple target point of small molecule tyrosine kinase inhibitors to HER 2 and HER1 after Lapatinib, and is an irreversible ErbB receptor tyrosine kinase inhibitor. Neratinib could selectively inhibit HER-1 and HER-2 of EGFR family(IC50 was 92 nmol/L and 59 nmol/L, respectively). Clinical research showed that Neratinib exerted significant therapeutic effect on non-small cell lung cancer, colon cancer, and breast cancer. The phaseⅡclinical trial indicated that Neratinib showed good efficacy and tolerance to HER-2 positive patients with advanced breast cancer who had been received or not Trastuzumab treatment. The phase Ⅲ breast cancer clinical trial was complete in September 2014. The data indicated that the efficacy of Neratinib was better than Roche's Herceptin in treatment of HER-2 positive early breast cancer. The above information is edited by the Chemicalbook of Liu Yujie.

252 supplier list of "Neratinib"

$0.00/ 1g

  • Product Name:Neratinib (HKI-272)
  • Products Intro:Purity: 98% HPLC | Package: 1g
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: Inosine pranobex,Probenecid,Sodium Ceftiofur,3-O-Ethyl-L-ascorbic acid,benzhexol hydrochloride
  • Product Name:Neratinib(HKI-272)
  • Products Intro:Purity: 98%(Min,HPLC) | Package: 100g;1kg;5kg,10kg,25kg,50kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: 1159983-30-8,89466-59-1,149739-51-5,104901-79-3,10541-83-0
  • Product Name:Neratinib
  • Products Intro:Purity: 99% | Package: 25KG;5KG;1KG
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Neratinib
  • Products Intro:Purity: As coa | Package: As request | CustNote: 698387-09-6
  • Company Type: Trader
  • Country/Region: CHINA
  • Product Name:Neratinib
  • Products Intro:Purity: 98% HPLC | Package: 5MG;10MG;50MG;100MG,1G,5G
  • Company Type: Reagent
  • Country/Region: CHINA

$7.00/ 1KG

  • Product Name: Neratinib
  • Products Intro:Purity: 99% | Package: 1KG;7USD
  • Company Type: Reagent
  • Country/Region: CHINA
  • Main Products: Nicotinamide riboside chloride,Curcumin,L(+)-Ascorbic acid,L-Glutamine,Stevioside Basic information
  • Product Name:Neratinib
  • Products Intro:Purity: 0.99 | Package: 5KG;1KG | CustNote: Have any requirements, pls contact sales@zetchem.com
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: pharmaceutical, agrochemical, speciality chemical and liquid crystal industries.
  • Product Name:Neratinib
  • Products Intro:Purity: >98% | Package: 500mg | CustNote: BOC Sciences also provides custom synthesis services for Neratinib.
  • Company Type: Trader
  • Country/Region: UNITED STATES
  • Product Name:Neratinib
  • Products Intro:Purity: 0.98 | Package: 1kg,2kg,5kg,10kg,25kg
  • Company Type: Trader
  • Country/Region: CHINA
  • Main Products: 2,7-ADA,2,4,6-Trichloroaniline,TRIMETHYLOXONIUM TETRAFLUOROBORATE,Zinc sulfide,5-HEXEN-1-OL
  • Product Name:neratinib
  • Products Intro:Purity: 0.99 | Package: 1kg
  • Company Type: Trader
  • Country/Region: CHINA
You can find Neratinib suppliers, manufacturers, and distributors from countries such as China, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.

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