Topotecan manufacturers and suppliers

Topotecan suppliers

Properties

Melting point:: −114 °C(lit.)

Boiling point:: >100 °C(lit.)

Density: 1.2 g/mL at 25 °C(lit.)

vapor density: 1.3 (vs air)

vapor pressure: 613 psi ( 21.1 °C)

Flash point:: 12 °C

storage temp.: Sealed in dry,Store in freezer, under -20°C

solubility: H₂O: soluble

form: liquid

pka: 8.92±0.40(Predicted)

color: yellow

Safety Information

Symbol(GHS): GHS08

Signal word: Danger

Hazard statements: H340-H361d

Precautionary statements: P201-P202-P280-P308+P313-P405-P501

Hazard Codes: T,C,F,Xi

Risk Statements: 36/37/38-67-35-20-11-34-48-46-36

Safety Statements: 26-45-36/37/39-37/39-36-22-24/25-16-7

RIDADR: UN 3286 3/PG 2

WGK Germany: 2

RTECS: MW4025000

F: 3

HazardClass: 8

PackingGroup: II

Use

Topotecan was launched in the US for the second-line treatment of ovarian cancer. It can be prepared in four steps from camptothecin and is a water soluble derivative of the natural product with decreased toxicity. Unlike its chemical relative irinotecan, topotecacan in not a prodrug and does not require bioactivation. It is an inhibitor of topoisomerase I. Specifically, it inhibits the release of topoisomerase I from DNA, where it relaxes supercoiled DNA, giving rise to single-strand breaks. When the replication fork reaches this complex, double-stand breaks can occur. This signals apoptosis and eventually gives rise to cell death. Evidence indicates hycamtin is safe for people with impaired hepatic function.

You can find Topotecan suppliers, manufacturers, and distributors from countries such as CHINA, United States and the United Kingdom here. Browse to the tetrahydrofuran product information displayed by the supplier, as well as the supplier's contact and capability information.