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ChemicalBook >> CAS DataBase List >> Dabrafenib

Dabrafenib

Dabrafenib price.
  • $9 - $5400
  • Product name: Dabrafenib
  • CAS: 1195765-45-7
  • MF: C23H20F3N5O2S2
  • MW: 519.56
  • EINECS:689-166-9
  • MDL Number:MFCD17215684
  • Synonyms:Dabrafenib;Dabrafenib free base(GSK2118436A);GSK2118436A;Dabrafenib (GSK2118436A);Dabrafenib KB-57246;Debrafenib API;BenzenesulfonaMide, N-[3-[5-(2-aMino-4-pyriMidinyl)-2-(1,1-diMethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-;N-(3-(5-(2-aminopyrimidin-4-yl)-2-tert-butylthiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide
Price42 Properties Safety Information Description
42 prices
Selected condition：
Brand
  • AK Scientific
  • Ambeed
  • ApexBio Technology
  • Apolloscientific
  • Arctom
  • Biorbyt Ltd
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • DC Chemicals
  • Matrix Scientific
  • SynChem
  • TRC
Package
  • 1mg
  • 5mg
  • 10mg
  • 20mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 500mg
  • 1g
  • 5g
  • 100 mg
  • 10mM(in 1mL DMSO)
  • ManufacturerAK Scientific
  • Product numberJ96885
  • Product descriptionDabrafenib
  • Packaging500mg
  • Price$390
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberY1871
  • Product descriptionDabrafenib
  • Packaging1g
  • Price$1001
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484347
  • Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
  • Packaging1mg
  • Price$9
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484347
  • Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
  • Packaging5mg
  • Price$15
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484347
  • Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
  • Packaging10mg
  • Price$20
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484347
  • Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
  • Packaging50mg
  • Price$34
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484347
  • Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
  • Packaging100mg
  • Price$44
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484347
  • Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
  • Packaging250mg
  • Price$87
  • Updated2021-12-16
  • Buy
  • ManufacturerAmbeed
  • Product numberA484347
  • Product descriptionN-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+%
  • Packaging1g
  • Price$218
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1407
  • Product descriptionDabrafenib(GSK2118436)
  • Packaging10mM(in 1mL DMSO)
  • Price$55
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1407
  • Product descriptionDabrafenib(GSK2118436)
  • Packaging10mg
  • Price$70
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB1407
  • Product descriptionDabrafenib(GSK2118436)
  • Packaging50mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0192
  • Product descriptionDabrafenib
  • Packaging1mg
  • Price$54
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0192
  • Product descriptionDabrafenib
  • Packaging5mg
  • Price$82
  • Updated2021-12-16
  • Buy
  • ManufacturerApolloscientific
  • Product numberBISN0192
  • Product descriptionDabrafenib
  • Packaging10mg
  • Price$115
  • Updated2021-12-16
  • Buy
  • ManufacturerArctom
  • Product numberCFN60005
  • Product descriptionDabrafenib ≥98%
  • Packaging20mg
  • Price$168
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific J96885 Dabrafenib 500mg $390 2021-12-16 Buy
AK Scientific Y1871 Dabrafenib 1g $1001 2021-12-16 Buy
Ambeed A484347 N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% 1mg $9 2021-12-16 Buy
Ambeed A484347 N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% 5mg $15 2021-12-16 Buy
Ambeed A484347 N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% 10mg $20 2021-12-16 Buy
Ambeed A484347 N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% 50mg $34 2021-12-16 Buy
Ambeed A484347 N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% 100mg $44 2021-12-16 Buy
Ambeed A484347 N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% 250mg $87 2021-12-16 Buy
Ambeed A484347 N-(3-(5-(2-Aminopyrimidin-4-yl)-2-(tert-butyl)thiazol-4-yl)-2-fluorophenyl)-2,6-difluorobenzenesulfonamide 98+% 1g $218 2021-12-16 Buy
ApexBio Technology B1407 Dabrafenib(GSK2118436) 10mM(in 1mL DMSO) $55 2021-12-16 Buy
ApexBio Technology B1407 Dabrafenib(GSK2118436) 10mg $70 2021-12-16 Buy
ApexBio Technology B1407 Dabrafenib(GSK2118436) 50mg $150 2021-12-16 Buy
Apolloscientific BISN0192 Dabrafenib 1mg $54 2021-12-16 Buy
Apolloscientific BISN0192 Dabrafenib 5mg $82 2021-12-16 Buy
Apolloscientific BISN0192 Dabrafenib 10mg $115 2021-12-16 Buy
Arctom CFN60005 Dabrafenib ≥98% 20mg $168 2021-12-16 Buy
Next Last

Properties

Melting point :214-216oC
Boiling point :653.7±65.0 °C(Predicted)
Density :1.443
storage temp. :-20°C
solubility :Soluble in DMSO (up to 30 mg/ml with warming), or in Ethanol (up to 1 mg/ml with warming).
form :White solid.
pka :6.62±0.10(Predicted)
color :Off-white
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H361 Suspected of damaging fertility or the unborn child Reproductive toxicity Category 2 Warning P201, P202, P281, P308+P313, P405,P501
H400 Very toxic to aquatic life Hazardous to the aquatic environment, acute hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
H411 Toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 2
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P273 Avoid release to the environment.
P281 Use personal protective equipment as required.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P391 Collect spillage. Hazardous to the aquatic environment
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Dabrafenib is a selective inhibitor of mutant B-RafV600E (IC50 = 0.8 nM), with 4- and 6-fold reduced potency against wild type B-Raf and c-Raf (IC50s = 3.2 and 5 nM, respectively). It has been investigated in clinical trials in patients with B-RafV600E metastatic melanoma and other solid tumors and is often combined with the MEK inhibitor trametinib to circumvent the development of B-Raf inhibitor resistance.

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Suppliers and manufacturers

Henan Bao Enluo International TradeCo.，LTD
Dabrafenib
$100.00 /1kg
Dabrafenib CAS:1195765-45-7
Zibo Hangyu Biotechnology Development Co., Ltd
Dabrafenib
$70.00 /1kg
Dabrafenib CAS:1195765-45-7
career henan chemical co
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide
$1.00 /1KG
N-[3-[5-(2-Amino-4-pyrimidinyl)-2-(tert-butyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide CAS:1195765-45-7
Shanghai Daken Advanced Materials Co.,Ltd
Henan Tianfu Chemical Co.,Ltd.
ATK CHEMICAL COMPANY LIMITED
Zhejiang ZETian Fine Chemicals Co. LTD
Hubei Jusheng Technology Co.,Ltd.
BOC Sciences
Chongqing Chemdad Co., Ltd