N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide
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- $28 - $7177
- Product name: N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide
- CAS: 1355326-35-0
- MF: C27H31FN4O2
- MW: 462.56
- EINECS:806-071-1
- MDL Number:MFCD24848688
- Synonyms:AGI-5198 (IDH-C35);N-cyclohexyl-2-(N-(3-fluorophenyl)-2-(2-Methyl-1H-iMidazol-1-yl)acetaMido)-2-(o-tolyl)acetaMide;IDH-C35 /IDHC35;N-CYCLOHEXYL-2-(N-(3-FLUOROPHENYL)-2-(2-METHYL-1H-IMIDAZOL-1-YL)ACETAMIDO)-2-(O-TOLYL)ACETAMIDE;AGI5198;IDH-C35 /IDHC35;IDH C35;IDH-C35;AGI5198;N-[2-(Cyclohexylamino)-1-(2-methylphenyl)-2-oxoethyl]-N-(3-fluorophenyl)-2-methyl-1H-imidazole-1-acetamide
30 prices
Selected condition：
Brand
- Adipogen Life Sciences
- AK Scientific
- ApexBio Technology
- Axon Medchem
- Biorbyt Ltd
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Matrix Scientific
- Sigma-Aldrich
- Tocris
- TRC
Package
- 1mg
- 1unit
- 5mg
- 10mg
- 25mg
- 50mg
- 25
- 100mg
- 200mg
- 250mg
- 500mg
- 10mM(in 1mL DMSO)
- 1g
- 5g
- 10g
- ManufacturerAdipogen Life Sciences
- Product numberAG-CR1-3528-M025
- Product descriptionAGI-5198 ≥98%(NMR)
- Packaging25mg
- Price$240
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberJ96661
- Product descriptionAGI5198
- Packaging10mg
- Price$144
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4339
- Product descriptionAGI-5198
- Packaging1unit
- Price$28
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4339
- Product descriptionAGI-5198
- Packaging5mg
- Price$120
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4339
- Product descriptionAGI-5198
- Packaging10mM(in 1mL DMSO)
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4339
- Product descriptionAGI-5198
- Packaging25mg
- Price$380
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2122
- Product descriptionAGI5198-IDH-C35 100%
- Packaging5mg
- Price$99
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon2122
- Product descriptionAGI5198-IDH-C35 100%
- Packaging25mg
- Price$341
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146237
- Product descriptionAGI-5198 >98%
- Packaging100mg
- Price$542.3
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146237
- Product descriptionAGI-5198 >98%
- Packaging250mg
- Price$986
- Updated2021-12-16
- Buy
- ManufacturerBiorbyt Ltd
- Product numberorb146237
- Product descriptionAGI-5198 >98%
- Packaging1g
- Price$2023
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number14624
- Product descriptionAGI-5198 ≥98%
- Packaging1mg
- Price$93
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14624
- Product descriptionAGI-5198 ≥98%
- Packaging5mg
- Price$252
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14624
- Product descriptionAGI-5198 ≥98%
- Packaging10mg
- Price$412
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number14624
- Product descriptionAGI-5198 ≥98%
- Packaging25mg
- Price$796
- Updated2024-03-01
- Buy
- ManufacturerChemenu
- Product numberCM249011
- Product descriptionAGI-5198(IDHC35) 98%
- Packaging100mg
- Price$314
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| Adipogen Life Sciences | AG-CR1-3528-M025 | AGI-5198 ≥98%(NMR) | 25mg | $240 | 2021-12-16 | Buy |
| AK Scientific | J96661 | AGI5198 | 10mg | $144 | 2021-12-16 | Buy |
| ApexBio Technology | A4339 | AGI-5198 | 1unit | $28 | 2021-12-16 | Buy |
| ApexBio Technology | A4339 | AGI-5198 | 5mg | $120 | 2021-12-16 | Buy |
| ApexBio Technology | A4339 | AGI-5198 | 10mM(in 1mL DMSO) | $130 | 2021-12-16 | Buy |
| ApexBio Technology | A4339 | AGI-5198 | 25mg | $380 | 2021-12-16 | Buy |
| Axon Medchem | Axon2122 | AGI5198-IDH-C35 100% | 5mg | $99 | 2021-12-16 | Buy |
| Axon Medchem | Axon2122 | AGI5198-IDH-C35 100% | 25mg | $341 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146237 | AGI-5198 >98% | 100mg | $542.3 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146237 | AGI-5198 >98% | 250mg | $986 | 2021-12-16 | Buy |
| Biorbyt Ltd | orb146237 | AGI-5198 >98% | 1g | $2023 | 2021-12-16 | Buy |
| Cayman Chemical | 14624 | AGI-5198 ≥98% | 1mg | $93 | 2024-03-01 | Buy |
| Cayman Chemical | 14624 | AGI-5198 ≥98% | 5mg | $252 | 2024-03-01 | Buy |
| Cayman Chemical | 14624 | AGI-5198 ≥98% | 10mg | $412 | 2024-03-01 | Buy |
| Cayman Chemical | 14624 | AGI-5198 ≥98% | 25mg | $796 | 2024-03-01 | Buy |
| Chemenu | CM249011 | AGI-5198(IDHC35) 98% | 100mg | $314 | 2021-12-16 | Buy |
Properties
Boiling point :707.6±60.0 °C(Predicted)
Density :1.21±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble3mg/mL, clear
form :powder
pka :14.02±0.20(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :FNYGWXSATBUBER-UHFFFAOYSA-N
Density :1.21±0.1 g/cm3(Predicted)
storage temp. :2-8°C
solubility :DMSO: soluble3mg/mL, clear
form :powder
pka :14.02±0.20(Predicted)
color :white to beige
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
InChIKey :FNYGWXSATBUBER-UHFFFAOYSA-N
Safety Information
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| Signal word: | Danger | ||||||||||||||
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Description
Isocitrate dehydrogenases (IDHs) are nicotinamide adenine dinucleotide (NAD+) and NAD phosphate (NADP+)-dependent enzymes in the tricarboxylic acid cycle that catalyze oxidative decarboxylation of isocitrate producing a-ketoglutarate (2-OG) and carbon dioxide. IDH1 and IDH2 are mutated in >70% of lower grade gliomas. The most common mutations map to arginine residues in the catalytic pockets of IDH1 (R132) or IDH2 (R140 and R172) and impart new gain of function catalytic activity leading to the NADPH-dependent conversion of 2-OG to 2-hydroxyglutarate (2-HG). AGI-5198 is a potent, selective inhibitor of IDH1 R132H and R132C mutants in vitro with IC50 values of 0.07 and 0.16 μM, respectively, but not wild-type IDH1, wild-type IDH2, or IDH2 mutants (IC50s > 100 μM). AGI-5198 has been shown to have anti-tumor efficacy in the TS603 glioma cell line and to lower tumor 2?HG production in HT1080 and U87MG cells with IC50 values of 0.48 and 0.07 μM, respectively. In R132H-IDH1 glioma xenografts, AGI-5198 (450 mg/kg/day) caused 50-60% growth inhibition over a treatment period of three weeks with no affect in the growth of IDH1 wild-type glioma xenografts. Under conditions of near complete 2-HG inhibition, AGI-5198 can induce demethylation of histone H3K9me3 and expression of genes associated with gliogenic differentiation.More related product prices
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