Danoprevir
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- $62 - $2075
- Product name: Danoprevir
- CAS: 850876-88-9
- MF: C35H46FN5O9S
- MW: 731.83
- EINECS:-0
- MDL Number:MFCD16038038
- Synonyms:RG7227, ITMN-191, RO5190591;4-Fluoro-1,3-dihydro-2H-isoindole-2-carboxylic acid (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester;ITMN-191;Danoprevir(ITMN-191);2H-Isoindole-2-carboxylic acid, 4-fluoro-1,3-dihydro-, (2R,6S,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-6-[[(1,1-dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester;dimethylethoxy)carbonyl]amino]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-2-yl ester Danoprevir (ITMN-191);Danoprevir, >=98%;Itmn-191 Danoprevir
33 prices
Selected condition：
Brand
- AK Scientific
- American Custom Chemicals Corporation
- ApexBio Technology
- Arctom
- Axon Medchem
- Biosynth Carbosynth
- Cayman Chemical
- Chemenu
- ChemScene
- Crysdot
- DC Chemicals
- Medical Isotopes, Inc.
- TRC
Package
- 1mg
- 2MG
- 2.5mg
- 10mM(in 1mL DMSO)
- 5mg
- 2x5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- ManufacturerAK Scientific
- Product numberX7550
- Product descriptionDanoprevir
- Packaging1mg
- Price$166
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7550
- Product descriptionDanoprevir
- Packaging5mg
- Price$332
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007175
- Product descriptionDANOPREVIR 99.00%
- Packaging2MG
- Price$262
- Updated2021-12-16
- Buy
- ManufacturerAmerican Custom Chemicals Corporation
- Product numberAPI0007175
- Product descriptionDANOPREVIR 99.00%
- Packaging5MG
- Price$502.71
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4024
- Product descriptionDanoprevir(RG7227)
- Packaging2mg
- Price$85
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4024
- Product descriptionDanoprevir(RG7227)
- Packaging5mg
- Price$130
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4024
- Product descriptionDanoprevir(RG7227)
- Packaging10mM(in 1mL DMSO)
- Price$210
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4024
- Product descriptionDanoprevir(RG7227)
- Packaging10mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerApexBio Technology
- Product numberA4024
- Product descriptionDanoprevir(RG7227)
- Packaging50mg
- Price$640
- Updated2021-12-16
- Buy
- ManufacturerArctom
- Product numberCFN60424
- Product descriptionDanoprevir(ITMN-191) ≥98%
- Packaging10mg
- Price$478
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1669
- Product descriptionDanoprevir-ITMN191|RG7227|R7227 99%
- Packaging5mg
- Price$132
- Updated2021-12-16
- Buy
- ManufacturerAxon Medchem
- Product numberAxon1669
- Product descriptionDanoprevir-ITMN191|RG7227|R7227 99%
- Packaging2x5mg
- Price$220
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD106410
- Product descriptionDanoprevir
- Packaging5mg
- Price$75
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD106410
- Product descriptionDanoprevir
- Packaging10mg
- Price$100
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD106410
- Product descriptionDanoprevir
- Packaging25mg
- Price$200
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFD106410
- Product descriptionDanoprevir
- Packaging50mg
- Price$350
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7550 | Danoprevir | 1mg | $166 | 2021-12-16 | Buy |
| AK Scientific | X7550 | Danoprevir | 5mg | $332 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007175 | DANOPREVIR 99.00% | 2MG | $262 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | API0007175 | DANOPREVIR 99.00% | 5MG | $502.71 | 2021-12-16 | Buy |
| ApexBio Technology | A4024 | Danoprevir(RG7227) | 2mg | $85 | 2021-12-16 | Buy |
| ApexBio Technology | A4024 | Danoprevir(RG7227) | 5mg | $130 | 2021-12-16 | Buy |
| ApexBio Technology | A4024 | Danoprevir(RG7227) | 10mM(in 1mL DMSO) | $210 | 2021-12-16 | Buy |
| ApexBio Technology | A4024 | Danoprevir(RG7227) | 10mg | $220 | 2021-12-16 | Buy |
| ApexBio Technology | A4024 | Danoprevir(RG7227) | 50mg | $640 | 2021-12-16 | Buy |
| Arctom | CFN60424 | Danoprevir(ITMN-191) ≥98% | 10mg | $478 | 2021-12-16 | Buy |
| Axon Medchem | Axon1669 | Danoprevir-ITMN191|RG7227|R7227 99% | 5mg | $132 | 2021-12-16 | Buy |
| Axon Medchem | Axon1669 | Danoprevir-ITMN191|RG7227|R7227 99% | 2x5mg | $220 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD106410 | Danoprevir | 5mg | $75 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD106410 | Danoprevir | 10mg | $100 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD106410 | Danoprevir | 25mg | $200 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FD106410 | Danoprevir | 50mg | $350 | 2021-12-16 | Buy |
Properties
Melting point :>165°C (dec.)
Density :1.41
storage temp. :-20°C Freezer
solubility :Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :4.43±0.60(Predicted)
color :White to Pale Beige
InChIKey :ZVTDLPBHTSMEJZ-AIYSODCISA-N
SMILES :C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O |t:33|
Density :1.41
storage temp. :-20°C Freezer
solubility :Acetone (Slightly), DMSO (Slightly), Methanol (Slightly)
form :Solid
pka :4.43±0.60(Predicted)
color :White to Pale Beige
InChIKey :ZVTDLPBHTSMEJZ-AIYSODCISA-N
SMILES :C1C2=C(C(F)=CC=C2)CN1C(O[C@H]1CN2C(=O)[C@@H](NC(OC(C)(C)C)=O)CCCCCC=C[C@]3([H])C[C@@]3(C(NS(C3CC3)(=O)=O)=O)NC(=O)[C@]2([H])C1)=O |t:33|
Safety Information
| Symbol(GHS): |
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| Signal word: | Warning | ||||||||||||||
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Description
Danoprevir is an orally bioavailable inhibitor of hepatitis C virus (HCV) nonstructural protein 3/4A (NS3/4A; IC50 = 1 nM), a serine protease essential for HCV replication. It is selective for NS3/4A over a panel of 53 proteases at a concentration of 10 μM. Danoprevir inhibits replication of the HCV genotypes 1a, 1b, 4, 5, and 6 (IC50s = 0.2-0.4 nM) as well as 2b and 3a (IC50s = 1.6 and 3.5 nM, respectively) in vitro. It also reduces the number of HCV genotype 1b replicons in Huh-7 cells (EC50 = 1.8 nM).Related product price
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