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ChemicalBook >> CAS DataBase List >> Acalabrutinib

Acalabrutinib

Acalabrutinib price.
  • $32 - $1744
  • Product name: Acalabrutinib
  • CAS: 1420477-60-6
  • MF: C26H23N7O2
  • MW: 465.51
  • EINECS:814-272-0
  • MDL Number:MFCD29472294
  • Synonyms:acalabrutinib;Benzamide, 4-[8-amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinyl-;ACP196,Acalabrutinib;4-[8-Amino-3-[(2S)-1-(1-oxo-2-butyn-1-yl)-2-pyrrolidinyl]imidazo[1,5-a]pyrazin-1-yl]-N-2-pyridinylbenzamide;(S)-4-(8-amino-3-(1-but-2-ynoylpyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide;Acalabrutinib (ACP-196);EOS-60753;ACP-196; ACP196; ACP 196
32 prices
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Brand

  • Abosyn
  • Activate Scientific
  • AK Scientific
  • American Custom Chemicals Corporation
  • ApexBio Technology
  • Biosynth Carbosynth
  • Cayman Chemical
  • ChemScene
  • Crysdot
  • DC Chemicals
  • TRC
  • Usbiological

Package

  • 1mg
  • 2mg
  • 2.5mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 200mg
  • 250mg
  • 1g
  • 5G
  • ManufacturerAbosyn
  • Product number10-3526
  • Product description(S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide 95%-98%
  • Packaging2mg
  • Price$870
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS59887
  • Product descriptionAcalabrutinib 95% ee
  • Packaging25mg
  • Price$94
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS59887
  • Product descriptionAcalabrutinib 95% ee
  • Packaging100mg
  • Price$154
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS59887
  • Product descriptionAcalabrutinib 95% ee
  • Packaging250mg
  • Price$314
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS59887
  • Product descriptionAcalabrutinib 95% ee
  • Packaging1g
  • Price$655
  • Updated2021-12-16
  • Buy
  • ManufacturerActivate Scientific
  • Product numberAS59887
  • Product descriptionAcalabrutinib 95% ee
  • Packaging5G
  • Price$1744
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX3870
  • Product descriptionAcalabrutinib
  • Packaging1mg
  • Price$46
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX3870
  • Product descriptionAcalabrutinib
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX3870
  • Product descriptionAcalabrutinib
  • Packaging10mg
  • Price$94
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0027385
  • Product description(S)-4-(8-AMINO-3-(1-(BUT-2-YNOYL)PYRROLIDIN-2-YL)IMIDAZO[1,5-A]PYRAZIN-1-YL)-N-(PYRIDIN-2-YL)BENZAMIDE 95.00%
  • Packaging5MG
  • Price$497.56
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6185
  • Product descriptionACP-196
  • Packaging5mg
  • Price$75
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6185
  • Product descriptionACP-196
  • Packaging25mg
  • Price$278
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberB6185
  • Product descriptionACP-196
  • Packaging100mg
  • Price$698
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA138815
  • Product descriptionAcalabrutinib
  • Packaging10mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA138815
  • Product descriptionAcalabrutinib
  • Packaging25mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerBiosynth Carbosynth
  • Product numberFA138815
  • Product descriptionAcalabrutinib
  • Packaging50mg
  • Price$200
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Abosyn 10-3526 (S)-4-(8-amino-3-(1-(but-2-ynoyl)pyrrolidin-2-yl)imidazo[1,5-a]pyrazin-1-yl)-N-(pyridin-2-yl)benzamide 95%-98% 2mg $870 2021-12-16 Buy
Activate Scientific AS59887 Acalabrutinib 95% ee 25mg $94 2021-12-16 Buy
Activate Scientific AS59887 Acalabrutinib 95% ee 100mg $154 2021-12-16 Buy
Activate Scientific AS59887 Acalabrutinib 95% ee 250mg $314 2021-12-16 Buy
Activate Scientific AS59887 Acalabrutinib 95% ee 1g $655 2021-12-16 Buy
Activate Scientific AS59887 Acalabrutinib 95% ee 5G $1744 2021-12-16 Buy
AK Scientific X3870 Acalabrutinib 1mg $46 2021-12-16 Buy
AK Scientific X3870 Acalabrutinib 5mg $75 2021-12-16 Buy
AK Scientific X3870 Acalabrutinib 10mg $94 2021-12-16 Buy
American Custom Chemicals Corporation API0027385 (S)-4-(8-AMINO-3-(1-(BUT-2-YNOYL)PYRROLIDIN-2-YL)IMIDAZO[1,5-A]PYRAZIN-1-YL)-N-(PYRIDIN-2-YL)BENZAMIDE 95.00% 5MG $497.56 2021-12-16 Buy
ApexBio Technology B6185 ACP-196 5mg $75 2021-12-16 Buy
ApexBio Technology B6185 ACP-196 25mg $278 2021-12-16 Buy
ApexBio Technology B6185 ACP-196 100mg $698 2021-12-16 Buy
Biosynth Carbosynth FA138815 Acalabrutinib 10mg $80 2021-12-16 Buy
Biosynth Carbosynth FA138815 Acalabrutinib 25mg $150 2021-12-16 Buy
Biosynth Carbosynth FA138815 Acalabrutinib 50mg $200 2021-12-16 Buy

Properties

Melting point :>133°C (dec.)
Density :1.37±0.1 g/cm3(Predicted)
storage temp. :Refrigerator
solubility :Soluble in DMSO (up to at least 25 mg/ml)
pka :11.47±0.70(Predicted)
form :solid
color :Yellow
Stability :Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning GHS hazard pictograms P264, P270, P301+P312, P330, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Acalabrutinib (ACP-196) is a selective second-generation Bruton's tyrosine kinase (BTK) inhibitor with an IC50 of 3 nM, which prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. ACP-196 has improved target specificity over ibrutinib with 323-, 94-, 19- and 9-fold selectivity over the other TEC kinase family members (ITK, TXK, BMX, and TEC, respectively) and no activity against EGFR.

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