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ChemicalBook >> CAS DataBase List >> Mildronate dihydrate

Mildronate dihydrate

Mildronate dihydrate price.
  • $34 - $475
  • Product name: Mildronate dihydrate
  • CAS: 86426-17-7
  • MF: C6H14N2O2.2H2O
  • MW: 182.218
  • EINECS:695-494-3
  • MDL Number:MFCD00876389
  • Synonyms:3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoate dihydrate;Mildronatedehydrate;Mildronate dihydrate;Hydrazinium, 2-(2-carboxyethyl)-1,1,1-trimethyl-, inner salt;Mildronate dihydrate, >=99%;Miridazine dihydrate;Meldonium dihydrate CRS;Phosphonate dihydrate
15 prices
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Brand

  • Adipogen Life Sciences
  • AK Scientific
  • Cayman Chemical
  • Crysdot
  • DC Chemicals
  • Sigma-Aldrich
  • TRC

Package

  • y0001670
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 1g
  • 25g
  • 100g
  • 500g
  • 1000g
  • ManufacturerAdipogen Life Sciences
  • Product numberCDX-M0558-M025
  • Product descriptionMildronate dihydrate ≥98%(HPLC)
  • Packaging25mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAK Scientific
  • Product numberX3418
  • Product descriptionMildronate dihydrate
  • Packaging25mg
  • Price$82
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number15997
  • Product descriptionMildronate (hydrate) ≥98%
  • Packaging10mg
  • Price$34
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15997
  • Product descriptionMildronate (hydrate) ≥98%
  • Packaging25mg
  • Price$76
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15997
  • Product descriptionMildronate (hydrate) ≥98%
  • Packaging50mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number15997
  • Product descriptionMildronate (hydrate) ≥98%
  • Packaging100mg
  • Price$166
  • Updated2024-03-01
  • Buy
  • ManufacturerCrysdot
  • Product numberCD13003048
  • Product descriptionMildronate dihydrate 95+%
  • Packaging25g
  • Price$40
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD13003048
  • Product descriptionMildronate dihydrate 95+%
  • Packaging100g
  • Price$99
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD13003048
  • Product descriptionMildronate dihydrate 95+%
  • Packaging500g
  • Price$297
  • Updated2021-12-16
  • Buy
  • ManufacturerCrysdot
  • Product numberCD13003048
  • Product descriptionMildronate dihydrate 95+%
  • Packaging1000g
  • Price$475
  • Updated2021-12-16
  • Buy
  • ManufacturerDC Chemicals
  • Product numberDC8947
  • Product descriptionMildronate,Meldonium >98%
  • Packaging1g
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberM5199
  • Product descriptionMildronate dihydrate ≥98% (HPLC), powder
  • Packaging5mg
  • Price$117
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberY0001670
  • Product descriptionMeldonium dihydrate European Pharmacopoeia (EP) Reference Standard
  • Packagingy0001670
  • Price$153
  • Updated2024-03-01
  • Buy
  • ManufacturerSigma-Aldrich
  • Product numberM5199
  • Product descriptionMildronate dihydrate ≥98% (HPLC), powder
  • Packaging25mg
  • Price$388
  • Updated2024-03-01
  • Buy
  • ManufacturerTRC
  • Product numberT896080
  • Product description3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoateDihydrate
  • Packaging25g
  • Price$145
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Adipogen Life Sciences CDX-M0558-M025 Mildronate dihydrate ≥98%(HPLC) 25mg $65 2021-12-16 Buy
AK Scientific X3418 Mildronate dihydrate 25mg $82 2021-12-16 Buy
Cayman Chemical 15997 Mildronate (hydrate) ≥98% 10mg $34 2024-03-01 Buy
Cayman Chemical 15997 Mildronate (hydrate) ≥98% 25mg $76 2024-03-01 Buy
Cayman Chemical 15997 Mildronate (hydrate) ≥98% 50mg $117 2024-03-01 Buy
Cayman Chemical 15997 Mildronate (hydrate) ≥98% 100mg $166 2024-03-01 Buy
Crysdot CD13003048 Mildronate dihydrate 95+% 25g $40 2021-12-16 Buy
Crysdot CD13003048 Mildronate dihydrate 95+% 100g $99 2021-12-16 Buy
Crysdot CD13003048 Mildronate dihydrate 95+% 500g $297 2021-12-16 Buy
Crysdot CD13003048 Mildronate dihydrate 95+% 1000g $475 2021-12-16 Buy
DC Chemicals DC8947 Mildronate,Meldonium >98% 1g $300 2021-12-16 Buy
Sigma-Aldrich M5199 Mildronate dihydrate ≥98% (HPLC), powder 5mg $117 2024-03-01 Buy
Sigma-Aldrich Y0001670 Meldonium dihydrate European Pharmacopoeia (EP) Reference Standard y0001670 $153 2024-03-01 Buy
Sigma-Aldrich M5199 Mildronate dihydrate ≥98% (HPLC), powder 25mg $388 2024-03-01 Buy
TRC T896080 3-(1,1,1-Trimethylhydrazin-1-ium-2-yl)propanoateDihydrate 25g $145 2021-12-16 Buy

Properties

Melting point :85 - 87°C
storage temp. :2-8°C
solubility :H2O: >40mg/mL
form :powder
color :white to off-white
Stability :Hygroscopic
InChIKey :JFWLFLLRLZSBRA-UHFFFAOYSA-N

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Description

Mildronate is a structural analog of γ-butyrobetaine (γBB), an intermediate in the biosynthesis of carnitine. It blocks carnitine synthesis by inhibiting γBB hydroxylase (IC50 = 62 μM) and, less potently, carnitine acetyltransferase (Ki = 1.6 mM). Through these actions, mildronate reduces the levels of free carnitine and long chain acyl carnitine. This leads to suppressed fatty acid metabolism and mitochondrial uncoupling during oxidative conditions, resulting in cardioprotective and neuroprotective effects. Mildronate also improves cognition and reduces amyloid-β pathology in a mouse model of Alzheimer’s disease.

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