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ChemicalBook >> CAS DataBase List >> N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide

N,O-Bis(trimethylsilyl)acetamide price.
  • $18 - $493
  • Product name: N,O-Bis(trimethylsilyl)acetamide
  • CAS: 10416-59-8
  • MF: C8H21NOSi2
  • MW: 203.43
  • EINECS:233-892-7
  • MDL Number:MFCD00008270
  • Synonyms:BIS(TRIMETHYLSILYL)ACETAMIDE;N,O-BIS(TRIMETHYLSILYL)ACETAMIDE;Acetimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester;bis(trimethylsllyl)acetamide ;CB2500;Ethanimidicacid,N-(trimethylsilyl)-,trimethylsilylester ;N-(Trimethylsilyl)acetimidic acid, trimethylsilyl ester;n-(trimethylsilyl)acetimidicacid,trimethylsilylester
20 prices
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Brand

  • Alfa Aesar
  • Sigma-Aldrich
  • TCI Chemical

Package

  • 1096490025
  • 5ml
  • 8187270100
  • 10x1ml
  • 10ml
  • 12mL
  • 25g
  • 25ml
  • 100ml
  • 100g
  • 1kit
  • 8187270025
  • 1l
  • ManufacturerAlfa Aesar
  • Product numberL00183
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide, 95%
  • Packaging25g
  • Price$33.1
  • Updated2018-11-13
  • Buy
  • ManufacturerAlfa Aesar
  • Product numberL00183
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide, 95%
  • Packaging100g
  • Price$85.6
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number128910
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95%
  • Packaging100ml
  • Price$88.5
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number128910
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95%
  • Packaging25ml
  • Price$35.8
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number15269
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for GC derivatization, ≥98.5% (GC)
  • Packaging5ml
  • Price$37.1
  • Updated2018-11-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number8.18727
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for synthesis. CAS 10416-59-8, EC Number 233-892-7, chemical formula CH CNSi(CH ) OSi(CH ) ., for synthesis
  • Packaging8187270025
  • Price$48
  • Updated2018-11-23
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number394831
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for GC derivatization
  • Packaging10x1ml
  • Price$106
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number15269
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for GC derivatization, ≥98.5% (GC)
  • Packaging10x1ml
  • Price$110
  • Updated2018-11-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number8.18727
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for synthesis. CAS 10416-59-8, EC Number 233-892-7, chemical formula CH CNSi(CH ) OSi(CH ) ., for synthesis
  • Packaging8187270100
  • Price$138
  • Updated2018-11-23
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number15269
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for GC derivatization, ≥98.5% (GC)
  • Packaging25ml
  • Price$149
  • Updated2018-11-20
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number1.09649
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide for gas chromatography. CAS 10416-59-8, EC Number 233-892-7, chemical formula CH CNSi(CH ) OSi(CH ) ., for gas chromatography
  • Packaging1096490025
  • Price$158
  • Updated2018-11-23
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number128910
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95%
  • Packaging1l
  • Price$493
  • Updated2018-11-13
  • Buy
  • ManufacturerSigma-Aldrich
  • Product number128910
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95%
  • Packaging10ml
  • Price$18.7
  • Updated2018-11-13
  • Buy
  • ManufacturerTCI Chemical
  • Product numberA5601
  • Product descriptionBSA [=N,O-Bis(trimethylsilyl)acetamide][for Gas Chromatography] >80.0%(GC)
  • Packaging5mL
  • Price$29
  • Updated2018-11-22
  • Buy
  • ManufacturerTCI Chemical
  • Product numberB0511
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide >80.0%(GC)
  • Packaging10mL
  • Price$18
  • Updated2018-11-22
  • Buy
  • ManufacturerTCI Chemical
  • Product numberB0510
  • Product descriptionN,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile)[Trimethylsilylating Reagent, for NH2 compounds]
  • Packaging12mL
  • Price$60
  • Updated2018-11-22
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
Alfa Aesar L00183 N,O-Bis(trimethylsilyl)acetamide, 95% 25g $33.1 2018-11-13 Buy
Alfa Aesar L00183 N,O-Bis(trimethylsilyl)acetamide, 95% 100g $85.6 2018-11-13 Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 100ml $88.5 2018-11-13 Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 25ml $35.8 2018-11-13 Buy
Sigma-Aldrich 15269 N,O-Bis(trimethylsilyl)acetamide for GC derivatization, ≥98.5% (GC) 5ml $37.1 2018-11-20 Buy
Sigma-Aldrich 8.18727 N,O-Bis(trimethylsilyl)acetamide for synthesis. CAS 10416-59-8, EC Number 233-892-7, chemical formula CH CNSi(CH ) OSi(CH ) ., for synthesis 8187270025 $48 2018-11-23 Buy
Sigma-Aldrich 394831 N,O-Bis(trimethylsilyl)acetamide for GC derivatization 10x1ml $106 2018-11-13 Buy
Sigma-Aldrich 15269 N,O-Bis(trimethylsilyl)acetamide for GC derivatization, ≥98.5% (GC) 10x1ml $110 2018-11-20 Buy
Sigma-Aldrich 8.18727 N,O-Bis(trimethylsilyl)acetamide for synthesis. CAS 10416-59-8, EC Number 233-892-7, chemical formula CH CNSi(CH ) OSi(CH ) ., for synthesis 8187270100 $138 2018-11-23 Buy
Sigma-Aldrich 15269 N,O-Bis(trimethylsilyl)acetamide for GC derivatization, ≥98.5% (GC) 25ml $149 2018-11-20 Buy
Sigma-Aldrich 1.09649 N,O-Bis(trimethylsilyl)acetamide for gas chromatography. CAS 10416-59-8, EC Number 233-892-7, chemical formula CH CNSi(CH ) OSi(CH ) ., for gas chromatography 1096490025 $158 2018-11-23 Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 1l $493 2018-11-13 Buy
Sigma-Aldrich 128910 N,O-Bis(trimethylsilyl)acetamide synthesis grade, ≥95% 10ml $18.7 2018-11-13 Buy
TCI Chemical A5601 BSA [=N,O-Bis(trimethylsilyl)acetamide][for Gas Chromatography] >80.0%(GC) 5mL $29 2018-11-22 Buy
TCI Chemical B0511 N,O-Bis(trimethylsilyl)acetamide >80.0%(GC) 10mL $18 2018-11-22 Buy
TCI Chemical B0510 N,O-Bis(trimethylsilyl)acetamide (25% in Acetonitrile)[Trimethylsilylating Reagent, for NH2 compounds] 12mL $60 2018-11-22 Buy

Properties

Melting point: :24 °C
Boiling point: :71-73 °C35 mm Hg(lit.)
Density  :0.832 g/mL at 20 °C(lit.)
vapor pressure  :10 hPa (50 °C)
refractive index  :n20/D 1.417(lit.)
Flash point: :53 °F
storage temp.  : 0-6°C
solubility  :Miscible with many nonpolar and polar aprotic solvents.
form  :Crystalline Powder, Crystals and/or Chunks
color  :Light yellow or beige to brown
Specific Gravity :0.832
Sensitive  :Moisture Sensitive
BRN  :1306669
CAS DataBase Reference :10416-59-8(CAS DataBase Reference)
NIST Chemistry Reference :Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)
EPA Substance Registry System :Ethanimidic acid, N-(trimethylsilyl)-, trimethylsilyl ester(10416-59-8)

Safety Information

Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H226 Flammable liquid and vapour Flammable liquids Category 3 Warning
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H311 Toxic in contact with skin Acute toxicity,dermal Category 3 Danger P280, P302+P352, P312, P322, P361,P363, P405, P501
H314 Causes severe skin burns and eye damage Skin corrosion/irritation Category 1A, B, C Danger P260,P264, P280, P301+P330+ P331,P303+P361+P353, P363, P304+P340,P310, P321, P305+ P351+P338, P405,P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H318 Causes serious eye damage Serious eye damage/eye irritation Category 1 Danger P280, P305+P351+P338, P310
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H370 Causes damage to organs Specific target organ toxicity, single exposure Category 1 Danger P260, P264, P270, P307+P311, P321,P405, P501
H373 May cause damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 2 Warning P260, P314, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P233 Keep container tightly closed.
P240 Ground/bond container and receiving equipment.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P310 Immediately call a POISON CENTER or doctor/physician.
P303+P361+P353 IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P307+P311 IF exposed: call a POISON CENTER or doctor/physician.
P370+P378 In case of fire: Use … for extinction.
P405 Store locked up.
P403+P235 Store in a well-ventilated place. Keep cool.
P501 Dispose of contents/container to..…

Description

N,O-Bis(trimethylsilyl)acetamide is used as a regioselective desulfation reagent as well as a preparatory agent for carbohydrate and alcohol trimethylsilyl ethers. It is also used for the derivatization of polar functional groups such as carboxylic acids, phenols, steroids, amines, alcohols, alkaloids and amides. It is employed in the formation of stable trimethylsilyl derivatives. Further, it is used in analytical chemistry for the derivatization of compounds in analysis to increase their volatility and to introduce the trimethylsilyl protecting group in organic synthesis. In addition to this, it is used in the protection of hydroxyl groups in natural products, functional groups in organic intermediates and derivatization reagent for gas chromatography-Mass spectral analysis of phenolic acids in fruits.

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