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ChemicalBook >> CAS DataBase List >> Epothilone B

Epothilone B

Epothilone B price.
  • $50 - $18416
  • Product name: Epothilone B
  • CAS: 152044-54-7
  • MF: C27H41NO6S
  • MW: 507.68
  • EINECS:604-822-6
  • MDL Number:MFCD02101921
  • Synonyms:Epothilone B(EPO906);Epothilone B HOUSE STANDARD;Epothilone B(Patupilone);(3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentaMethyl-3-((E)-1-(2-Methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecan-5,9-dione;Epothilone B (EPO906, Patupilone);EPOTHILONE;(1S,3S,7S,10R,11S,12S,16R,E)-7,11-dihydroxy-8,8,10,12,16-pentamethyl-3-(1-(2-methylthiazol-4-yl)prop-1-en-2-yl)-4,17-dioxa-bicyclo[14.1.0]heptadecane-5,9-dione;Patupilone (1S,3S,7S,10R,11S,12S,16R)-7,11-Dihydroxy-8,8,10,12,16-pentamethyl-3-[(1E)-1-methyl-2-(2-methyl-4-thiazolyl)ethenyl]-4,17-dioxabicyclo[14.1.0]heptadecane-5,9-dione
36 prices
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Brand

  • American Custom Chemicals Corporation
  • ApexBio Technology
  • AvaChem
  • Biorbyt Ltd
  • Cayman Chemical
  • Chem-Impex
  • ChemScene
  • Crysdot
  • DC Chemicals
  • Labseeker
  • Medical Isotopes, Inc.
  • Sigma-Aldrich
  • TCI Chemical
  • TRC
  • Usbiological

Package

  • 10mM(in 1mL DMSO)
  • 100ug
  • 0.1MG
  • 1MG
  • 2mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • 250mg
  • 1g
  • 5g
  • 10g
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005272
  • Product descriptionPATUPILONE 95.00%
  • Packaging0.1MG
  • Price$406
  • Updated2021-12-16
  • Buy
  • ManufacturerAmerican Custom Chemicals Corporation
  • Product numberAPI0005272
  • Product descriptionPATUPILONE 95.00%
  • Packaging1MG
  • Price$460
  • Updated2021-12-16
  • Buy
  • ManufacturerApexBio Technology
  • Product numberA1630
  • Product descriptionEpothiloneB(EPO906,Patupilone)
  • Packaging10mM(in 1mL DMSO)
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3099
  • Product descriptionEpothilone B
  • Packaging5mg
  • Price$65
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3099
  • Product descriptionEpothilone B
  • Packaging10mg
  • Price$110
  • Updated2021-12-16
  • Buy
  • ManufacturerAvaChem
  • Product number3099
  • Product descriptionEpothilone B
  • Packaging25mg
  • Price$225
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545992
  • Product descriptionEpothilone B >98%
  • Packaging1mg
  • Price$154.7
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb545992
  • Product descriptionEpothilone B >98%
  • Packaging5mg
  • Price$357
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154682
  • Product descriptionEpothilone B >99%
  • Packaging100mg
  • Price$912.9
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154682
  • Product descriptionEpothilone B >99%
  • Packaging250mg
  • Price$1802
  • Updated2021-12-16
  • Buy
  • ManufacturerBiorbyt Ltd
  • Product numberorb154682
  • Product descriptionEpothilone B >99%
  • Packaging1g
  • Price$3728.1
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number10924
  • Product descriptionEpothilone B ≥95%
  • Packaging1mg
  • Price$109
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10924
  • Product descriptionEpothilone B ≥95%
  • Packaging5mg
  • Price$481
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number10924
  • Product descriptionEpothilone B ≥95%
  • Packaging10mg
  • Price$856
  • Updated2024-03-01
  • Buy
  • ManufacturerChem-Impex
  • Product number37869
  • Product descriptionEpothiloneB,≥95%(HPLC) ≥95%(HPLC)
  • Packaging25MG
  • Price$488.05
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0714
  • Product descriptionEpothilone B 99.88%
  • Packaging2mg
  • Price$50
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
American Custom Chemicals Corporation API0005272 PATUPILONE 95.00% 0.1MG $406 2021-12-16 Buy
American Custom Chemicals Corporation API0005272 PATUPILONE 95.00% 1MG $460 2021-12-16 Buy
ApexBio Technology A1630 EpothiloneB(EPO906,Patupilone) 10mM(in 1mL DMSO) $80 2021-12-16 Buy
AvaChem 3099 Epothilone B 5mg $65 2021-12-16 Buy
AvaChem 3099 Epothilone B 10mg $110 2021-12-16 Buy
AvaChem 3099 Epothilone B 25mg $225 2021-12-16 Buy
Biorbyt Ltd orb545992 Epothilone B >98% 1mg $154.7 2021-12-16 Buy
Biorbyt Ltd orb545992 Epothilone B >98% 5mg $357 2021-12-16 Buy
Biorbyt Ltd orb154682 Epothilone B >99% 100mg $912.9 2021-12-16 Buy
Biorbyt Ltd orb154682 Epothilone B >99% 250mg $1802 2021-12-16 Buy
Biorbyt Ltd orb154682 Epothilone B >99% 1g $3728.1 2021-12-16 Buy
Cayman Chemical 10924 Epothilone B ≥95% 1mg $109 2024-03-01 Buy
Cayman Chemical 10924 Epothilone B ≥95% 5mg $481 2024-03-01 Buy
Cayman Chemical 10924 Epothilone B ≥95% 10mg $856 2024-03-01 Buy
Chem-Impex 37869 EpothiloneB,≥95%(HPLC) ≥95%(HPLC) 25MG $488.05 2021-12-16 Buy
ChemScene CS-0714 Epothilone B 99.88% 2mg $50 2021-12-16 Buy

Properties

Melting point :95-97°C
alpha :D21 -35° (c = 0.7 in methanol)
Boiling point :680.2±55.0 °C(Predicted)
Density :1.136
storage temp. :Store at -20°C
solubility :Soluble in DMSO (up to 40 mg/ml) or in Ethanol (up to 35 mg/ml).
form :White to off-white solid
pka :13.57±0.70(Predicted)
color :colorless
Stability :Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
InChIKey :QXRSDHAAWVKZLJ-PVYNADRNSA-N
CAS DataBase Reference :152044-54-7

Safety Information

Symbol(GHS): GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H300 Fatal if swallowed Acute toxicity,oral Category 1, 2 Danger GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
H310 Fatal in contact with skin Acute toxicity,dermal Category 1, 2 Danger GHS hazard pictograms P262, P264, P270, P280, P302+P350,P310, P322, P361, P363, P405, P501
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H317 May cause an allergic skin reaction Sensitisation, Skin Category 1 Warning GHS hazard pictograms P261, P272, P280, P302+P352,P333+P313, P321, P363, P501
H341 Suspected of causing genetic defects Germ cell mutagenicity Category 2 Warning P201,P202, P281, P308+P313, P405,P501
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger GHS hazard pictograms
H372 Causes damage to organs through prolonged or repeated exposure Specific target organ toxicity, repeated exposure Category 1 Danger GHS hazard pictograms P260, P264, P270, P314, P501
H410 Very toxic to aquatic life with long lasting effects Hazardous to the aquatic environment, long-term hazard Category 1 Warning GHS hazard pictograms P273, P391, P501
Precautionary statements:
P201 Obtain special instructions before use.
P202 Do not handle until all safety precautions have been read and understood.
P260 Do not breathe dust/fume/gas/mist/vapours/spray.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P262 Do not get in eyes, on skin, or on clothing.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P270 Do not eat, drink or smoke when using this product.
P272 Contaminated work clothing should not be allowed out of the workplace.
P273 Avoid release to the environment.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P281 Use personal protective equipment as required.
P301+P310 IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P302+P350 IF ON SKIN: Gently wash with plenty of soap and water.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P308+P313 IF exposed or concerned: Get medical advice/attention.
P310 Immediately call a POISON CENTER or doctor/physician.
P314 Get medical advice/attention if you feel unwell.
P321 Specific treatment (see … on this label).
P322 Specific measures (see …on this label).
P330 Rinse mouth.
P332+P313 IF SKIN irritation occurs: Get medical advice/attention.
P333+P313 IF SKIN irritation or rash occurs: Get medical advice/attention.
P361 Remove/Take off immediately all contaminated clothing.
P362 Take off contaminated clothing and wash before reuse.
P363 Wash contaminated clothing before reuse.
P391 Collect spillage. Hazardous to the aquatic environment
P405 Store locked up.
P501 Dispose of contents/container to..…

Description

Epothilone B (Epo B) is a macrolide that causes the formation of bundles of intracellular microtubules in non-mitotic cells, induces the formation of hyperstable tubulin polymers, and arrests cell cycling in mitosis. It induces mitotic arrest at the G2-M transition in Hs578T and HeLa cells (IC50 = 3 and 32 nM, respectively) as well as in multidrug resistant KB3-1 and KBV-1 cells (IC50 = 16 and 92 nM, respectively). Epo B causes cell cycle arrest at nanomolar IC50 values in cell lines from ovarian, breast, lung, colon, prostate, and squamous cancer.

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